Biomarker in der Wundheilung und Wundtherapie

Background
Diagnostic options to analyze the prevailing complex microenvironment of chronic difficult to heal wounds and to guide wound treatment are rare; however, monitoring and steering parameters are urgently needed to adequately navigate modern therapeutic options. Biomarkers can open a diagnostic window for the future of individualized, personalized wound medicine.

Objective
Presentation of current findings in the fields of biomarker development and implementation in wound healing and wound treatment.

Material and methods
An extensive literature search of medical databases (MEDLINE, EMBASE, Cochrane) was performed. Based on the current literature, potential biomarkers in wound healing and wound care are presented, explained and evaluated. Furthermore, an outlook on the future development of new approaches of biomarker detection is given.

Results and conclusion
In particular, the topics of the wound microenvironment pH, proteases and the proteolytic environment of the wound, the objective quantification of microbial burden as well as markers of wound infection and chronic inflammation are addressed in the current research. First promising methods, point of care diagnostics and results show the potential of biomarker-driven wound medicine. Modern approaches, such as the analysis of biomolecular signatures via omics methodology can further objectify diagnostics and individualized treatment management in the future and contribute to the achievement of better therapeutic results.