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Biology and clinical relevance of EpCAM

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Biology and clinical relevance of EpCAM. / Keller, Laura; Werner, Stefan; Pantel, Klaus.

In: CELL STRESS, Vol. 3, No. 6, 21.05.2019, p. 165-180.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Keller, L, Werner, S & Pantel, K 2019, 'Biology and clinical relevance of EpCAM', CELL STRESS, vol. 3, no. 6, pp. 165-180. https://doi.org/10.15698/cst2019.06.188

APA

Keller, L., Werner, S., & Pantel, K. (2019). Biology and clinical relevance of EpCAM. CELL STRESS, 3(6), 165-180. https://doi.org/10.15698/cst2019.06.188

Vancouver

Keller L, Werner S, Pantel K. Biology and clinical relevance of EpCAM. CELL STRESS. 2019 May 21;3(6):165-180. https://doi.org/10.15698/cst2019.06.188

Bibtex

@article{575d90fff23a4a869f01ce2fc8ef9d88,
title = "Biology and clinical relevance of EpCAM",
abstract = "Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM expression is limited to normal and malignant epithelia, it has been used as diagnostic marker for the detection of carcinoma cells in mesenchymal organs such as blood, bone marrow or lymph nodes. In particular, the detection and molecular characterization of EpCAM-positive circulating tumor cells (CTCs) in the blood of carcinoma patients has gained considerable interest over the past ten years. EpCAM is primarily considered as an adhesion molecule, but recent studies have shown diverse biological functions including regulation of cell proliferation and cancer stemness. In this review, we summarize the current knowledge on the biological properties of EpCAM with emphasis on mechanisms involved in cancer progression and discuss the clinical implications of these findings for the clinical use of EpCAM as a diagnostic marker.",
author = "Laura Keller and Stefan Werner and Klaus Pantel",
year = "2019",
month = may,
day = "21",
doi = "10.15698/cst2019.06.188",
language = "English",
volume = "3",
pages = "165--180",
journal = "CELL STRESS",
issn = "2523-0204",
publisher = "Shared Science Publishers OG",
number = "6",

}

RIS

TY - JOUR

T1 - Biology and clinical relevance of EpCAM

AU - Keller, Laura

AU - Werner, Stefan

AU - Pantel, Klaus

PY - 2019/5/21

Y1 - 2019/5/21

N2 - Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM expression is limited to normal and malignant epithelia, it has been used as diagnostic marker for the detection of carcinoma cells in mesenchymal organs such as blood, bone marrow or lymph nodes. In particular, the detection and molecular characterization of EpCAM-positive circulating tumor cells (CTCs) in the blood of carcinoma patients has gained considerable interest over the past ten years. EpCAM is primarily considered as an adhesion molecule, but recent studies have shown diverse biological functions including regulation of cell proliferation and cancer stemness. In this review, we summarize the current knowledge on the biological properties of EpCAM with emphasis on mechanisms involved in cancer progression and discuss the clinical implications of these findings for the clinical use of EpCAM as a diagnostic marker.

AB - Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM expression is limited to normal and malignant epithelia, it has been used as diagnostic marker for the detection of carcinoma cells in mesenchymal organs such as blood, bone marrow or lymph nodes. In particular, the detection and molecular characterization of EpCAM-positive circulating tumor cells (CTCs) in the blood of carcinoma patients has gained considerable interest over the past ten years. EpCAM is primarily considered as an adhesion molecule, but recent studies have shown diverse biological functions including regulation of cell proliferation and cancer stemness. In this review, we summarize the current knowledge on the biological properties of EpCAM with emphasis on mechanisms involved in cancer progression and discuss the clinical implications of these findings for the clinical use of EpCAM as a diagnostic marker.

U2 - 10.15698/cst2019.06.188

DO - 10.15698/cst2019.06.188

M3 - SCORING: Review article

C2 - 31225512

VL - 3

SP - 165

EP - 180

JO - CELL STRESS

JF - CELL STRESS

SN - 2523-0204

IS - 6

ER -