Biologic factors associated with tumor oxygenation are prognostic in patients with stage III esophageal cancer: long-term results
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Biologic factors associated with tumor oxygenation are prognostic in patients with stage III esophageal cancer: long-term results. / Rades, Dirk; Bajrovic, Amira; Schild, Steven E; Thorns, Christoph; Kilic, Ergin.
In: ANTICANCER RES, Vol. 34, No. 8, 08.2014, p. 4351-5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Biologic factors associated with tumor oxygenation are prognostic in patients with stage III esophageal cancer: long-term results
AU - Rades, Dirk
AU - Bajrovic, Amira
AU - Schild, Steven E
AU - Thorns, Christoph
AU - Kilic, Ergin
N1 - Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
PY - 2014/8
Y1 - 2014/8
N2 - BACKGROUND/AIM: Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented.PATIENTS AND METHODS: In 64 patients, the impact of tumor cell expression of erythropoietin (EPO) and erythropoietin-receptor (EPO-R) and ten additional factors (age, gender, performance status, tumor length, tumor stage (T-stage), nodes (N-stage), histology/grading, hemoglobin levels during radiotherapy, surgery) on survival and loco-regional control was evaluated up to 10 years following radio-chemotherapy.RESULTS: On multivariate analysis, improved survival was associated with low EPO-R expression (p=0.034) and hemoglobin levels during radiotherapy ≥ 12 g/dl (p=0.026). Low EPO expression was associated with survival on univariate (p=0.010) but not on multivariate analysis (p=0.42). On multivariate analysis, improved loco-regional control was significantly associated with hemoglobin levels during radiotherapy ≥ 12 g/dl (p<0.001).CONCLUSION: The long-term results confirm that hemoglobin levels during radiotherapy and tumor cell expression of EPO-R are significant prognostic factors in patients with locally advanced esophageal cancer.
AB - BACKGROUND/AIM: Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented.PATIENTS AND METHODS: In 64 patients, the impact of tumor cell expression of erythropoietin (EPO) and erythropoietin-receptor (EPO-R) and ten additional factors (age, gender, performance status, tumor length, tumor stage (T-stage), nodes (N-stage), histology/grading, hemoglobin levels during radiotherapy, surgery) on survival and loco-regional control was evaluated up to 10 years following radio-chemotherapy.RESULTS: On multivariate analysis, improved survival was associated with low EPO-R expression (p=0.034) and hemoglobin levels during radiotherapy ≥ 12 g/dl (p=0.026). Low EPO expression was associated with survival on univariate (p=0.010) but not on multivariate analysis (p=0.42). On multivariate analysis, improved loco-regional control was significantly associated with hemoglobin levels during radiotherapy ≥ 12 g/dl (p<0.001).CONCLUSION: The long-term results confirm that hemoglobin levels during radiotherapy and tumor cell expression of EPO-R are significant prognostic factors in patients with locally advanced esophageal cancer.
KW - Adult
KW - Aged
KW - Erythropoietin
KW - Esophageal Neoplasms
KW - Female
KW - Hemoglobins
KW - Humans
KW - Male
KW - Middle Aged
KW - Neoplasm Staging
KW - Oxygen
KW - Prognosis
KW - Receptors, Erythropoietin
KW - Time Factors
M3 - SCORING: Journal article
C2 - 25075070
VL - 34
SP - 4351
EP - 4355
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 8
ER -
