Biocompatibility and Osseointegration of Titanium Implants with a Silver-Doped Polysiloxane Coating: An In Vivo Pig Model

TY - JOUR

T1 - Biocompatibility and Osseointegration of Titanium Implants with a Silver-Doped Polysiloxane Coating: An In Vivo Pig Model

AU - Smeets, Ralf

AU - Precht, Clarissa

AU - Hahn, Michael

AU - Jung, Ole

AU - Hartjen, Philip

AU - Heiland, Max

AU - Gröbe, Alexander

AU - Holthaus, Marzellus Große

AU - Hanken, Henning

PY - 2017/11

Y1 - 2017/11

N2 - PURPOSE: To test the antimicrobial properties, surface topography, reaction of surrounding tissue (biocompatibility), and osseointegration of ultrathin implant surfaces containing polysiloxane and nanoscaled silver particles.MATERIALS AND METHODS: Implants with polysiloxane coating and nanoscaled silver particles (Ag/SiOxCy; HyProtect, Bio-Gate) were compared with implants with polysiloxane coating alone and with noncoated (grit-blasted and acid-etched) implants. A total of 72 implants were inserted into the calvaria of eight domestic pigs (nine implants each, three of each type). After 3 months, histologic sections were evaluated for inflammatory cell infiltration and bone implant contact.RESULTS: Roughness parameters did not differ between all three implant types. The Ag/SiOxCy coating exhibited a good antimicrobial effect in vitro and no sign of inflammatory cell infiltration in vivo. The noncoated implants demonstrated 10.85% and 14.48% more bone contact than the polysiloxane-coated implants (P = .003) and the Ag/SiOxCy‑coated implants (P ≤ .001), respectively. Osseointegration was not significantly different between the Ag/SiOxCy‑coated and polysiloxane-coated implants (P = .72).CONCLUSION: The osseointegration capability of the Ag/SiOxCy-coated implants was equal to that of the polysiloxane-coated implants but less than that of the grit-blasted and acid-etched implants. Because of the biocompatibility of the polysiloxane coating, further studies should be conducted in load-bearing models and in the oral cavity to investigate the antimicrobial effect of the embedded silver clusters.

AB - PURPOSE: To test the antimicrobial properties, surface topography, reaction of surrounding tissue (biocompatibility), and osseointegration of ultrathin implant surfaces containing polysiloxane and nanoscaled silver particles.MATERIALS AND METHODS: Implants with polysiloxane coating and nanoscaled silver particles (Ag/SiOxCy; HyProtect, Bio-Gate) were compared with implants with polysiloxane coating alone and with noncoated (grit-blasted and acid-etched) implants. A total of 72 implants were inserted into the calvaria of eight domestic pigs (nine implants each, three of each type). After 3 months, histologic sections were evaluated for inflammatory cell infiltration and bone implant contact.RESULTS: Roughness parameters did not differ between all three implant types. The Ag/SiOxCy coating exhibited a good antimicrobial effect in vitro and no sign of inflammatory cell infiltration in vivo. The noncoated implants demonstrated 10.85% and 14.48% more bone contact than the polysiloxane-coated implants (P = .003) and the Ag/SiOxCy‑coated implants (P ≤ .001), respectively. Osseointegration was not significantly different between the Ag/SiOxCy‑coated and polysiloxane-coated implants (P = .72).CONCLUSION: The osseointegration capability of the Ag/SiOxCy-coated implants was equal to that of the polysiloxane-coated implants but less than that of the grit-blasted and acid-etched implants. Because of the biocompatibility of the polysiloxane coating, further studies should be conducted in load-bearing models and in the oral cavity to investigate the antimicrobial effect of the embedded silver clusters.

KW - Journal Article

U2 - 10.11607/jomi.5533

DO - 10.11607/jomi.5533

M3 - SCORING: Journal article

C2 - 29028852

VL - 32

SP - 1338

EP - 1345

JO - INT J ORAL MAX IMPL

JF - INT J ORAL MAX IMPL

SN - 0882-2786

IS - 6

ER -