Bile resistance of coated transjugular intrahepatic portosystemic shunt stents in a flow-model.
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Bile resistance of coated transjugular intrahepatic portosystemic shunt stents in a flow-model. / Wittkugel, Oliver; Koops, Andreas; Habermann, Christian R; Weiss, Florian; Adam, Gerhard; Krupski, Gerrit.
In: INVEST RADIOL, Vol. 39, No. 12, 12, 2004, p. 717-722.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Bile resistance of coated transjugular intrahepatic portosystemic shunt stents in a flow-model.
AU - Wittkugel, Oliver
AU - Koops, Andreas
AU - Habermann, Christian R
AU - Weiss, Florian
AU - Adam, Gerhard
AU - Krupski, Gerrit
PY - 2004
Y1 - 2004
N2 - PURPOSE: We sought to test the bile resistance of transjugular intrahepatic portosystemic shunt (TIPS) stents with 3 different coatings. MATERIALS AND METHODS: Three stents with different coating materials (monolayer polyethylene terephthalate [PETP], monolayer polytetrafluoroethylene [PTFE], and double layer [PTFE]) were tested in a flow model. After testing the sealing of the system with isotonic saline solution, fresh human bile was circulated. Constant pressure was 50 cm H2O. Bile resistance of the stent membranes was analyzed. RESULTS: Two of the 3 stents proved completely resistant to water. Only the PETP stent was resistant to bile. The PTFE-coated stents were not bile resistant. CONCLUSION: The bile resistance of coated TIPS stents and, thus, the dependency of TIPS shunt patency is called into question. The stent with the reported superior patency rates does not show experimental bile resistance.
AB - PURPOSE: We sought to test the bile resistance of transjugular intrahepatic portosystemic shunt (TIPS) stents with 3 different coatings. MATERIALS AND METHODS: Three stents with different coating materials (monolayer polyethylene terephthalate [PETP], monolayer polytetrafluoroethylene [PTFE], and double layer [PTFE]) were tested in a flow model. After testing the sealing of the system with isotonic saline solution, fresh human bile was circulated. Constant pressure was 50 cm H2O. Bile resistance of the stent membranes was analyzed. RESULTS: Two of the 3 stents proved completely resistant to water. Only the PETP stent was resistant to bile. The PTFE-coated stents were not bile resistant. CONCLUSION: The bile resistance of coated TIPS stents and, thus, the dependency of TIPS shunt patency is called into question. The stent with the reported superior patency rates does not show experimental bile resistance.
M3 - SCORING: Zeitschriftenaufsatz
VL - 39
SP - 717
EP - 722
JO - INVEST RADIOL
JF - INVEST RADIOL
SN - 0020-9996
IS - 12
M1 - 12
ER -