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Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans

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Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans. / Helfrich, Randolph F; Lendner, Janna D; Mander, Bryce A; Guillen, Heriberto; Paff, Michelle; Mnatsakanyan, Lilit; Vadera, Sumeet; Walker, Matthew P; Lin, Jack J; Knight, Robert T.

In: NAT COMMUN, Vol. 10, No. 1, 08.08.2019, p. 3572.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Helfrich, RF, Lendner, JD, Mander, BA, Guillen, H, Paff, M, Mnatsakanyan, L, Vadera, S, Walker, MP, Lin, JJ & Knight, RT 2019, 'Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans', NAT COMMUN, vol. 10, no. 1, pp. 3572. https://doi.org/10.1038/s41467-019-11444-x

APA

Helfrich, R. F., Lendner, J. D., Mander, B. A., Guillen, H., Paff, M., Mnatsakanyan, L., Vadera, S., Walker, M. P., Lin, J. J., & Knight, R. T. (2019). Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans. NAT COMMUN, 10(1), 3572. https://doi.org/10.1038/s41467-019-11444-x

Vancouver

Helfrich RF, Lendner JD, Mander BA, Guillen H, Paff M, Mnatsakanyan L et al. Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans. NAT COMMUN. 2019 Aug 8;10(1):3572. https://doi.org/10.1038/s41467-019-11444-x

Bibtex

@article{bad8abcd59554218b5ac08a2bceb9dae,
title = "Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans",
abstract = "How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of these cardinal sleep oscillations is organized to support information reactivation and transfer. Here, using human intracranial recordings, we demonstrate that the prefrontal cortex plays a key role in organizing the ripple-mediated information transfer during non-rapid eye movement (NREM) sleep. We reveal a temporally precise form of coupling between prefrontal slow-wave and spindle oscillations, which actively dictates the hippocampal-neocortical dialogue and information transfer. Our results suggest a model of the human sleeping brain in which rapid bidirectional interactions, triggered by the prefrontal cortex, mediate hippocampal activation to optimally time subsequent information transfer to the neocortex during NREM sleep.",
author = "Helfrich, {Randolph F} and Lendner, {Janna D} and Mander, {Bryce A} and Heriberto Guillen and Michelle Paff and Lilit Mnatsakanyan and Sumeet Vadera and Walker, {Matthew P} and Lin, {Jack J} and Knight, {Robert T}",
year = "2019",
month = aug,
day = "8",
doi = "10.1038/s41467-019-11444-x",
language = "English",
volume = "10",
pages = "3572",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Bidirectional prefrontal-hippocampal dynamics organize information transfer during sleep in humans

AU - Helfrich, Randolph F

AU - Lendner, Janna D

AU - Mander, Bryce A

AU - Guillen, Heriberto

AU - Paff, Michelle

AU - Mnatsakanyan, Lilit

AU - Vadera, Sumeet

AU - Walker, Matthew P

AU - Lin, Jack J

AU - Knight, Robert T

PY - 2019/8/8

Y1 - 2019/8/8

N2 - How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of these cardinal sleep oscillations is organized to support information reactivation and transfer. Here, using human intracranial recordings, we demonstrate that the prefrontal cortex plays a key role in organizing the ripple-mediated information transfer during non-rapid eye movement (NREM) sleep. We reveal a temporally precise form of coupling between prefrontal slow-wave and spindle oscillations, which actively dictates the hippocampal-neocortical dialogue and information transfer. Our results suggest a model of the human sleeping brain in which rapid bidirectional interactions, triggered by the prefrontal cortex, mediate hippocampal activation to optimally time subsequent information transfer to the neocortex during NREM sleep.

AB - How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of these cardinal sleep oscillations is organized to support information reactivation and transfer. Here, using human intracranial recordings, we demonstrate that the prefrontal cortex plays a key role in organizing the ripple-mediated information transfer during non-rapid eye movement (NREM) sleep. We reveal a temporally precise form of coupling between prefrontal slow-wave and spindle oscillations, which actively dictates the hippocampal-neocortical dialogue and information transfer. Our results suggest a model of the human sleeping brain in which rapid bidirectional interactions, triggered by the prefrontal cortex, mediate hippocampal activation to optimally time subsequent information transfer to the neocortex during NREM sleep.

U2 - 10.1038/s41467-019-11444-x

DO - 10.1038/s41467-019-11444-x

M3 - SCORING: Journal article

C2 - 31395890

VL - 10

SP - 3572

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -