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Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation

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Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation. / Mandel, Jonathan; Casari, Martina; Stepanyan, Maria; Martyanov, Alexey; Deppermann, Carsten.

In: INT J MOL SCI, Vol. 23, No. 7, 3868, 31.03.2022.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Mandel, J, Casari, M, Stepanyan, M, Martyanov, A & Deppermann, C 2022, 'Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation', INT J MOL SCI, vol. 23, no. 7, 3868. https://doi.org/10.3390/ijms23073868

APA

Mandel, J., Casari, M., Stepanyan, M., Martyanov, A., & Deppermann, C. (2022). Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation. INT J MOL SCI, 23(7), [3868]. https://doi.org/10.3390/ijms23073868

Vancouver

Mandel J, Casari M, Stepanyan M, Martyanov A, Deppermann C. Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation. INT J MOL SCI. 2022 Mar 31;23(7). 3868. https://doi.org/10.3390/ijms23073868

Bibtex

@article{dae80cc744804ec5bc41a7ee33e5203d,
title = "Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation",
abstract = "There is accumulating evidence that platelets play roles beyond their traditional functions in thrombosis and hemostasis, e.g., in inflammatory processes, infection and cancer, and that they interact, stimulate and regulate cells of the innate immune system such as neutrophils, monocytes and macrophages. In this review, we will focus on platelet activation in hemostatic and inflammatory processes, as well as platelet interactions with neutrophils and monocytes/macrophages. We take a closer look at the contributions of major platelet receptors GPIb, αIIbβ3, TLT-1, CLEC-2 and Toll-like receptors (TLRs) as well as secretions from platelet granules on platelet-neutrophil aggregate and neutrophil extracellular trap (NET) formation in atherosclerosis, transfusion-related acute lung injury (TRALI) and COVID-19. Further, we will address platelet-monocyte and macrophage interactions during cancer metastasis, infection, sepsis and platelet clearance.",
keywords = "Blood Platelets/pathology, COVID-19, Hemostasis, Humans, Immunity, Innate, Inflammation/pathology, Neutrophils/pathology, Platelet Activation, Thromboinflammation, Thrombosis/pathology",
author = "Jonathan Mandel and Martina Casari and Maria Stepanyan and Alexey Martyanov and Carsten Deppermann",
year = "2022",
month = mar,
day = "31",
doi = "10.3390/ijms23073868",
language = "English",
volume = "23",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "7",

}

RIS

TY - JOUR

T1 - Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation

AU - Mandel, Jonathan

AU - Casari, Martina

AU - Stepanyan, Maria

AU - Martyanov, Alexey

AU - Deppermann, Carsten

PY - 2022/3/31

Y1 - 2022/3/31

N2 - There is accumulating evidence that platelets play roles beyond their traditional functions in thrombosis and hemostasis, e.g., in inflammatory processes, infection and cancer, and that they interact, stimulate and regulate cells of the innate immune system such as neutrophils, monocytes and macrophages. In this review, we will focus on platelet activation in hemostatic and inflammatory processes, as well as platelet interactions with neutrophils and monocytes/macrophages. We take a closer look at the contributions of major platelet receptors GPIb, αIIbβ3, TLT-1, CLEC-2 and Toll-like receptors (TLRs) as well as secretions from platelet granules on platelet-neutrophil aggregate and neutrophil extracellular trap (NET) formation in atherosclerosis, transfusion-related acute lung injury (TRALI) and COVID-19. Further, we will address platelet-monocyte and macrophage interactions during cancer metastasis, infection, sepsis and platelet clearance.

AB - There is accumulating evidence that platelets play roles beyond their traditional functions in thrombosis and hemostasis, e.g., in inflammatory processes, infection and cancer, and that they interact, stimulate and regulate cells of the innate immune system such as neutrophils, monocytes and macrophages. In this review, we will focus on platelet activation in hemostatic and inflammatory processes, as well as platelet interactions with neutrophils and monocytes/macrophages. We take a closer look at the contributions of major platelet receptors GPIb, αIIbβ3, TLT-1, CLEC-2 and Toll-like receptors (TLRs) as well as secretions from platelet granules on platelet-neutrophil aggregate and neutrophil extracellular trap (NET) formation in atherosclerosis, transfusion-related acute lung injury (TRALI) and COVID-19. Further, we will address platelet-monocyte and macrophage interactions during cancer metastasis, infection, sepsis and platelet clearance.

KW - Blood Platelets/pathology

KW - COVID-19

KW - Hemostasis

KW - Humans

KW - Immunity, Innate

KW - Inflammation/pathology

KW - Neutrophils/pathology

KW - Platelet Activation

KW - Thromboinflammation

KW - Thrombosis/pathology

U2 - 10.3390/ijms23073868

DO - 10.3390/ijms23073868

M3 - SCORING: Review article

C2 - 35409226

VL - 23

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 7

M1 - 3868

ER -