Research ExplorerPublicationsBET-inhibition by JQ1 promotes proliferation and self-renewa...

BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells

Standard

BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells. / Wroblewski, Mark; Scheller-Wendorff, Marina; Udonta, Florian; Bauer, Raimund; Schlichting, Jara; Zhao, Lin; Ben Batalla, Isabel; Gensch, Victoria; Päsler, Sarina; Wu, Lei; Wanior, Marek; Taipaleenmäki, Hanna; Bolamperti, Simona; Najafova, Zeynab; Pantel, Klaus; Bokemeyer, Carsten; Qi, Jun; Hesse, Eric; Knapp, Stefan; Johnsen, Steven; Loges, Sonja.

In: HAEMATOLOGICA, Vol. 103, No. 6, 06.2018, p. 939-948.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wroblewski, M, Scheller-Wendorff, M, Udonta, F, Bauer, R, Schlichting, J, Zhao, L, Ben Batalla, I, Gensch, V, Päsler, S, Wu, L, Wanior, M, Taipaleenmäki, H, Bolamperti, S, Najafova, Z, Pantel, K, Bokemeyer, C, Qi, J, Hesse, E, Knapp, S, Johnsen, S & Loges, S 2018, 'BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells', HAEMATOLOGICA, vol. 103, no. 6, pp. 939-948. https://doi.org/10.3324/haematol.2017.181354

APA

Wroblewski, M., Scheller-Wendorff, M., Udonta, F., Bauer, R., Schlichting, J., Zhao, L., Ben Batalla, I., Gensch, V., Päsler, S., Wu, L., Wanior, M., Taipaleenmäki, H., Bolamperti, S., Najafova, Z., Pantel, K., Bokemeyer, C., Qi, J., Hesse, E., Knapp, S., ... Loges, S. (2018). BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells. HAEMATOLOGICA, 103(6), 939-948. https://doi.org/10.3324/haematol.2017.181354

Vancouver

Wroblewski M, Scheller-Wendorff M, Udonta F, Bauer R, Schlichting J, Zhao L et al. BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells. HAEMATOLOGICA. 2018 Jun;103(6):939-948. https://doi.org/10.3324/haematol.2017.181354

Bibtex

@article{6250e08256b3447b9d944b399705cc42,
title = "BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells",
abstract = "Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (stem) cells is urgently needed. We found that JQ1 treatment decreases the numbers of pre-, immature and mature B cells while numbers of early pro-B cells remain constant. In addition, JQ1 treatment increases apoptosis in T cells, all together leading to reduced cellularity in thymus, bone marrow and spleen. Furthermore, JQ1 induces proliferation of long-term hematopoietic stem cells, thereby increasing stem cell numbers. Due to increased numbers, JQ1-treated hematopoietic stem cells engrafted better after stem cell transplantation and repopulated the hematopoietic system significantly faster after sublethal myeloablation. As quantity and functionality of hematopoietic stem cells determine the duration of life-threatening myelosuppression, BET inhibition might benefit patients in myelosuppressive conditions.",
keywords = "Journal Article",
author = "Mark Wroblewski and Marina Scheller-Wendorff and Florian Udonta and Raimund Bauer and Jara Schlichting and Lin Zhao and {Ben Batalla}, Isabel and Victoria Gensch and Sarina P{\"a}sler and Lei Wu and Marek Wanior and Hanna Taipaleenm{\"a}ki and Simona Bolamperti and Zeynab Najafova and Klaus Pantel and Carsten Bokemeyer and Jun Qi and Eric Hesse and Stefan Knapp and Steven Johnsen and Sonja Loges",
note = "Copyright {\textcopyright} 2018 Ferrata Storti Foundation.",
year = "2018",
month = jun,
doi = "10.3324/haematol.2017.181354",
language = "English",
volume = "103",
pages = "939--948",
journal = "HAEMATOLOGICA",
issn = "0390-6078",
publisher = "Ferrata Storti Foundation",
number = "6",

}

RIS

TY - JOUR

T1 - BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells

AU - Wroblewski, Mark

AU - Scheller-Wendorff, Marina

AU - Udonta, Florian

AU - Bauer, Raimund

AU - Schlichting, Jara

AU - Zhao, Lin

AU - Ben Batalla, Isabel

AU - Gensch, Victoria

AU - Päsler, Sarina

AU - Wu, Lei

AU - Wanior, Marek

AU - Taipaleenmäki, Hanna

AU - Bolamperti, Simona

AU - Najafova, Zeynab

AU - Pantel, Klaus

AU - Bokemeyer, Carsten

AU - Qi, Jun

AU - Hesse, Eric

AU - Knapp, Stefan

AU - Johnsen, Steven

AU - Loges, Sonja

N1 - Copyright © 2018 Ferrata Storti Foundation.

PY - 2018/6

Y1 - 2018/6

N2 - Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (stem) cells is urgently needed. We found that JQ1 treatment decreases the numbers of pre-, immature and mature B cells while numbers of early pro-B cells remain constant. In addition, JQ1 treatment increases apoptosis in T cells, all together leading to reduced cellularity in thymus, bone marrow and spleen. Furthermore, JQ1 induces proliferation of long-term hematopoietic stem cells, thereby increasing stem cell numbers. Due to increased numbers, JQ1-treated hematopoietic stem cells engrafted better after stem cell transplantation and repopulated the hematopoietic system significantly faster after sublethal myeloablation. As quantity and functionality of hematopoietic stem cells determine the duration of life-threatening myelosuppression, BET inhibition might benefit patients in myelosuppressive conditions.

AB - Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (stem) cells is urgently needed. We found that JQ1 treatment decreases the numbers of pre-, immature and mature B cells while numbers of early pro-B cells remain constant. In addition, JQ1 treatment increases apoptosis in T cells, all together leading to reduced cellularity in thymus, bone marrow and spleen. Furthermore, JQ1 induces proliferation of long-term hematopoietic stem cells, thereby increasing stem cell numbers. Due to increased numbers, JQ1-treated hematopoietic stem cells engrafted better after stem cell transplantation and repopulated the hematopoietic system significantly faster after sublethal myeloablation. As quantity and functionality of hematopoietic stem cells determine the duration of life-threatening myelosuppression, BET inhibition might benefit patients in myelosuppressive conditions.

KW - Journal Article

U2 - 10.3324/haematol.2017.181354

DO - 10.3324/haematol.2017.181354

M3 - SCORING: Journal article

C2 - 29567778

VL - 103

SP - 939

EP - 948

JO - HAEMATOLOGICA

JF - HAEMATOLOGICA

SN - 0390-6078

IS - 6

ER -