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Benzodiazepine use among patients in heroin-assisted vs. methadone maintenance treatment findings of the German randomized controlled trial

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Benzodiazepine use among patients in heroin-assisted vs. methadone maintenance treatment findings of the German randomized controlled trial. / Eiroa-Orosa, Francisco Jose; Haasen, Christian; Verthein, Uwe; Dilg, Christoph; Schäfer, Ingo; Reimer, Jens.

In: DRUG ALCOHOL DEPEN, Vol. 112, No. 3, 3, 01.12.2010, p. 226-233.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Eiroa-Orosa, FJ, Haasen, C, Verthein, U, Dilg, C, Schäfer, I & Reimer, J 2010, 'Benzodiazepine use among patients in heroin-assisted vs. methadone maintenance treatment findings of the German randomized controlled trial', DRUG ALCOHOL DEPEN, vol. 112, no. 3, 3, pp. 226-233. https://doi.org/10.1016/j.drugalcdep.2010.06.013

APA

Eiroa-Orosa, F. J., Haasen, C., Verthein, U., Dilg, C., Schäfer, I., & Reimer, J. (2010). Benzodiazepine use among patients in heroin-assisted vs. methadone maintenance treatment findings of the German randomized controlled trial. DRUG ALCOHOL DEPEN, 112(3), 226-233. [3]. https://doi.org/10.1016/j.drugalcdep.2010.06.013

Vancouver

Eiroa-Orosa FJ, Haasen C, Verthein U, Dilg C, Schäfer I, Reimer J. Benzodiazepine use among patients in heroin-assisted vs. methadone maintenance treatment findings of the German randomized controlled trial. DRUG ALCOHOL DEPEN. 2010 Dec 1;112(3):226-233. 3. https://doi.org/10.1016/j.drugalcdep.2010.06.013

Bibtex

@article{83f146bb7ab240deb767c2f6cf1833b8,
title = "Benzodiazepine use among patients in heroin-assisted vs. methadone maintenance treatment findings of the German randomized controlled trial",
abstract = "Benzodiazepine (BZD) use has been found to be associated with poorer psychosocial adjustment, higher levels of polydrug use and more risk-taking behaviors among opioid dependent patients. The aim of this paper is to analyze the correlation between BZD use, BZD prescription and treatment outcome among participants in the German trial on heroin-assisted treatment. 1015 patients who participated in the study comparing heroin-assisted and methadone maintenance treatment (HAT ; MMT) for 12 months were included in the analysis. Analyses were carried out to assess the association of treatment outcome with baseline BZD use, with ongoing BZD use and with different patterns of BZD prescription. Baseline BZD use correlated with lower retention rates but not with poorer outcome. Ongoing BZD use correlated with poorer outcomes. Significantly better outcomes were found in the course of phobic anxiety symptomatology for those with regular prescription of BZD. The percentage of BZD positive urine tests decreased more in HAT than in MMT. Poorer outcome for benzodiazepine users may be mediated by a higher severity of addiction. Cautious prescribing of benzodiazepines may be beneficial due to the reduction of overall illicit use.",
keywords = "Anti-Anxiety Agents, Benzodiazepines, Drug Prescriptions, Female, Germany, Heroin, Heroin Dependence, Humans, Male, Methadone, Opiate Substitution Treatment, Opioid-Related Disorders, Prescriptions, Psychiatric Status Rating Scales, Risk-Taking, Substance-Related Disorders, Treatment Outcome, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",
author = "Eiroa-Orosa, {Francisco Jose} and Christian Haasen and Uwe Verthein and Christoph Dilg and Ingo Sch{\"a}fer and Jens Reimer",
note = "Copyright {\textcopyright} 2010 Elsevier Ireland Ltd. All rights reserved.",
year = "2010",
month = dec,
day = "1",
doi = "10.1016/j.drugalcdep.2010.06.013",
language = "English",
volume = "112",
pages = "226--233",
journal = "DRUG ALCOHOL DEPEN",
issn = "0376-8716",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Benzodiazepine use among patients in heroin-assisted vs. methadone maintenance treatment findings of the German randomized controlled trial

AU - Eiroa-Orosa, Francisco Jose

AU - Haasen, Christian

AU - Verthein, Uwe

AU - Dilg, Christoph

AU - Schäfer, Ingo

AU - Reimer, Jens

N1 - Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Benzodiazepine (BZD) use has been found to be associated with poorer psychosocial adjustment, higher levels of polydrug use and more risk-taking behaviors among opioid dependent patients. The aim of this paper is to analyze the correlation between BZD use, BZD prescription and treatment outcome among participants in the German trial on heroin-assisted treatment. 1015 patients who participated in the study comparing heroin-assisted and methadone maintenance treatment (HAT ; MMT) for 12 months were included in the analysis. Analyses were carried out to assess the association of treatment outcome with baseline BZD use, with ongoing BZD use and with different patterns of BZD prescription. Baseline BZD use correlated with lower retention rates but not with poorer outcome. Ongoing BZD use correlated with poorer outcomes. Significantly better outcomes were found in the course of phobic anxiety symptomatology for those with regular prescription of BZD. The percentage of BZD positive urine tests decreased more in HAT than in MMT. Poorer outcome for benzodiazepine users may be mediated by a higher severity of addiction. Cautious prescribing of benzodiazepines may be beneficial due to the reduction of overall illicit use.

AB - Benzodiazepine (BZD) use has been found to be associated with poorer psychosocial adjustment, higher levels of polydrug use and more risk-taking behaviors among opioid dependent patients. The aim of this paper is to analyze the correlation between BZD use, BZD prescription and treatment outcome among participants in the German trial on heroin-assisted treatment. 1015 patients who participated in the study comparing heroin-assisted and methadone maintenance treatment (HAT ; MMT) for 12 months were included in the analysis. Analyses were carried out to assess the association of treatment outcome with baseline BZD use, with ongoing BZD use and with different patterns of BZD prescription. Baseline BZD use correlated with lower retention rates but not with poorer outcome. Ongoing BZD use correlated with poorer outcomes. Significantly better outcomes were found in the course of phobic anxiety symptomatology for those with regular prescription of BZD. The percentage of BZD positive urine tests decreased more in HAT than in MMT. Poorer outcome for benzodiazepine users may be mediated by a higher severity of addiction. Cautious prescribing of benzodiazepines may be beneficial due to the reduction of overall illicit use.

KW - Anti-Anxiety Agents

KW - Benzodiazepines

KW - Drug Prescriptions

KW - Female

KW - Germany

KW - Heroin

KW - Heroin Dependence

KW - Humans

KW - Male

KW - Methadone

KW - Opiate Substitution Treatment

KW - Opioid-Related Disorders

KW - Prescriptions

KW - Psychiatric Status Rating Scales

KW - Risk-Taking

KW - Substance-Related Disorders

KW - Treatment Outcome

KW - Journal Article

KW - Multicenter Study

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.drugalcdep.2010.06.013

DO - 10.1016/j.drugalcdep.2010.06.013

M3 - SCORING: Journal article

C2 - 20708349

VL - 112

SP - 226

EP - 233

JO - DRUG ALCOHOL DEPEN

JF - DRUG ALCOHOL DEPEN

SN - 0376-8716

IS - 3

M1 - 3

ER -