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Behavioral and biological effects of acute beta-endorphin injection in schizophrenic and depressed patients.

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Behavioral and biological effects of acute beta-endorphin injection in schizophrenic and depressed patients. / Pickar, D; Davis, G C; Schulz, S C; Extein, I; Wagner, R; Naber, Dieter; Gold, P W; van Kammen, D P; Goodwin, F K; Wyatt, R J; Li, C H; Bunney, W E.

In: AM J PSYCHIAT, Vol. 138, No. 2, 2, 1981, p. 160-166.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pickar, D, Davis, GC, Schulz, SC, Extein, I, Wagner, R, Naber, D, Gold, PW, van Kammen, DP, Goodwin, FK, Wyatt, RJ, Li, CH & Bunney, WE 1981, 'Behavioral and biological effects of acute beta-endorphin injection in schizophrenic and depressed patients.', AM J PSYCHIAT, vol. 138, no. 2, 2, pp. 160-166. <http://www.ncbi.nlm.nih.gov/pubmed/6257125?dopt=Citation>

APA

Pickar, D., Davis, G. C., Schulz, S. C., Extein, I., Wagner, R., Naber, D., Gold, P. W., van Kammen, D. P., Goodwin, F. K., Wyatt, R. J., Li, C. H., & Bunney, W. E. (1981). Behavioral and biological effects of acute beta-endorphin injection in schizophrenic and depressed patients. AM J PSYCHIAT, 138(2), 160-166. [2]. http://www.ncbi.nlm.nih.gov/pubmed/6257125?dopt=Citation

Vancouver

Pickar D, Davis GC, Schulz SC, Extein I, Wagner R, Naber D et al. Behavioral and biological effects of acute beta-endorphin injection in schizophrenic and depressed patients. AM J PSYCHIAT. 1981;138(2):160-166. 2.

Bibtex

@article{a2e5862735244a87a3802974a02f5eb5,
title = "Behavioral and biological effects of acute beta-endorphin injection in schizophrenic and depressed patients.",
abstract = "In this double-blind study, beta-endorphin, 4-15 mg, was administered intravenously to 6 schizophrenic and 4 depressed patients. There were neither significant differences in behavioral ratings between beta-endorphin and placebo for the overall group nor for either the schizophrenic or depressed subgroup. Clinical worsening and improvement were observed in individual schizophrenic patients. There was no evidence of late-appearing therapeutic effects in 4 schizophrenic patients rated for 5 consecutive days after placebo and drug infusions. In 1 patient 10 mg of beta-endorphin produced neuroendocrine effects comparable to those produced by 5 mg of intravenously administered methadone; in 2 other patients it produced large increases in circulating opioid activity as determined by radioreceptor assay. These biological data support the notion that parenterally administered beta-endorphin exerts significant opiate-like activity in vivo.",
author = "D Pickar and Davis, {G C} and Schulz, {S C} and I Extein and R Wagner and Dieter Naber and Gold, {P W} and {van Kammen}, {D P} and Goodwin, {F K} and Wyatt, {R J} and Li, {C H} and Bunney, {W E}",
year = "1981",
language = "Deutsch",
volume = "138",
pages = "160--166",
journal = "AM J PSYCHIAT",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "2",

}

RIS

TY - JOUR

T1 - Behavioral and biological effects of acute beta-endorphin injection in schizophrenic and depressed patients.

AU - Pickar, D

AU - Davis, G C

AU - Schulz, S C

AU - Extein, I

AU - Wagner, R

AU - Naber, Dieter

AU - Gold, P W

AU - van Kammen, D P

AU - Goodwin, F K

AU - Wyatt, R J

AU - Li, C H

AU - Bunney, W E

PY - 1981

Y1 - 1981

N2 - In this double-blind study, beta-endorphin, 4-15 mg, was administered intravenously to 6 schizophrenic and 4 depressed patients. There were neither significant differences in behavioral ratings between beta-endorphin and placebo for the overall group nor for either the schizophrenic or depressed subgroup. Clinical worsening and improvement were observed in individual schizophrenic patients. There was no evidence of late-appearing therapeutic effects in 4 schizophrenic patients rated for 5 consecutive days after placebo and drug infusions. In 1 patient 10 mg of beta-endorphin produced neuroendocrine effects comparable to those produced by 5 mg of intravenously administered methadone; in 2 other patients it produced large increases in circulating opioid activity as determined by radioreceptor assay. These biological data support the notion that parenterally administered beta-endorphin exerts significant opiate-like activity in vivo.

AB - In this double-blind study, beta-endorphin, 4-15 mg, was administered intravenously to 6 schizophrenic and 4 depressed patients. There were neither significant differences in behavioral ratings between beta-endorphin and placebo for the overall group nor for either the schizophrenic or depressed subgroup. Clinical worsening and improvement were observed in individual schizophrenic patients. There was no evidence of late-appearing therapeutic effects in 4 schizophrenic patients rated for 5 consecutive days after placebo and drug infusions. In 1 patient 10 mg of beta-endorphin produced neuroendocrine effects comparable to those produced by 5 mg of intravenously administered methadone; in 2 other patients it produced large increases in circulating opioid activity as determined by radioreceptor assay. These biological data support the notion that parenterally administered beta-endorphin exerts significant opiate-like activity in vivo.

M3 - SCORING: Zeitschriftenaufsatz

VL - 138

SP - 160

EP - 166

JO - AM J PSYCHIAT

JF - AM J PSYCHIAT

SN - 0002-953X

IS - 2

M1 - 2

ER -