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Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond

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Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond. / Cumberland, Max J; Riebel, Leto L; Roy, Ashwin; O'Shea, Christopher; Holmes, Andrew P; Denning, Chris; Kirchhof, Paulus; Rodriguez, Blanca; Gehmlich, Katja.

In: FRONT PHYSIOL, Vol. 13, 806366, 2022.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Cumberland, MJ, Riebel, LL, Roy, A, O'Shea, C, Holmes, AP, Denning, C, Kirchhof, P, Rodriguez, B & Gehmlich, K 2022, 'Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond', FRONT PHYSIOL, vol. 13, 806366. https://doi.org/10.3389/fphys.2022.806366

APA

Cumberland, M. J., Riebel, L. L., Roy, A., O'Shea, C., Holmes, A. P., Denning, C., Kirchhof, P., Rodriguez, B., & Gehmlich, K. (2022). Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond. FRONT PHYSIOL, 13, [806366]. https://doi.org/10.3389/fphys.2022.806366

Vancouver

Cumberland MJ, Riebel LL, Roy A, O'Shea C, Holmes AP, Denning C et al. Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond. FRONT PHYSIOL. 2022;13. 806366. https://doi.org/10.3389/fphys.2022.806366

Bibtex

@article{f745960265d34950adacff7290b11aed,
title = "Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond",
abstract = "Patients with heart failure often develop cardiac arrhythmias. The mechanisms and interrelations linking heart failure and arrhythmias are not fully understood. Historically, research into arrhythmias has been performed on affected individuals or in vivo (animal) models. The latter however is constrained by interspecies variation, demands to reduce animal experiments and cost. Recent developments in in vitro induced pluripotent stem cell technology and in silico modelling have expanded the number of models available for the evaluation of heart failure and arrhythmia. An agnostic approach, combining the modalities discussed here, has the potential to improve our understanding for appraising the pathology and interactions between heart failure and arrhythmia and can provide robust and validated outcomes in a variety of research settings. This review discusses the state of the art models, methodologies and techniques used in the evaluation of heart failure and arrhythmia and will highlight the benefits of using them in combination. Special consideration is paid to assessing the pivotal role calcium handling has in the development of heart failure and arrhythmia.",
author = "Cumberland, {Max J} and Riebel, {Leto L} and Ashwin Roy and Christopher O'Shea and Holmes, {Andrew P} and Chris Denning and Paulus Kirchhof and Blanca Rodriguez and Katja Gehmlich",
note = "Copyright {\textcopyright} 2022 Cumberland, Riebel, Roy, O{\textquoteright}Shea, Holmes, Denning, Kirchhof, Rodriguez and Gehmlich.",
year = "2022",
doi = "10.3389/fphys.2022.806366",
language = "English",
volume = "13",
journal = "FRONT PHYSIOL",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond

AU - Cumberland, Max J

AU - Riebel, Leto L

AU - Roy, Ashwin

AU - O'Shea, Christopher

AU - Holmes, Andrew P

AU - Denning, Chris

AU - Kirchhof, Paulus

AU - Rodriguez, Blanca

AU - Gehmlich, Katja

N1 - Copyright © 2022 Cumberland, Riebel, Roy, O’Shea, Holmes, Denning, Kirchhof, Rodriguez and Gehmlich.

PY - 2022

Y1 - 2022

N2 - Patients with heart failure often develop cardiac arrhythmias. The mechanisms and interrelations linking heart failure and arrhythmias are not fully understood. Historically, research into arrhythmias has been performed on affected individuals or in vivo (animal) models. The latter however is constrained by interspecies variation, demands to reduce animal experiments and cost. Recent developments in in vitro induced pluripotent stem cell technology and in silico modelling have expanded the number of models available for the evaluation of heart failure and arrhythmia. An agnostic approach, combining the modalities discussed here, has the potential to improve our understanding for appraising the pathology and interactions between heart failure and arrhythmia and can provide robust and validated outcomes in a variety of research settings. This review discusses the state of the art models, methodologies and techniques used in the evaluation of heart failure and arrhythmia and will highlight the benefits of using them in combination. Special consideration is paid to assessing the pivotal role calcium handling has in the development of heart failure and arrhythmia.

AB - Patients with heart failure often develop cardiac arrhythmias. The mechanisms and interrelations linking heart failure and arrhythmias are not fully understood. Historically, research into arrhythmias has been performed on affected individuals or in vivo (animal) models. The latter however is constrained by interspecies variation, demands to reduce animal experiments and cost. Recent developments in in vitro induced pluripotent stem cell technology and in silico modelling have expanded the number of models available for the evaluation of heart failure and arrhythmia. An agnostic approach, combining the modalities discussed here, has the potential to improve our understanding for appraising the pathology and interactions between heart failure and arrhythmia and can provide robust and validated outcomes in a variety of research settings. This review discusses the state of the art models, methodologies and techniques used in the evaluation of heart failure and arrhythmia and will highlight the benefits of using them in combination. Special consideration is paid to assessing the pivotal role calcium handling has in the development of heart failure and arrhythmia.

U2 - 10.3389/fphys.2022.806366

DO - 10.3389/fphys.2022.806366

M3 - SCORING: Review article

C2 - 35197863

VL - 13

JO - FRONT PHYSIOL

JF - FRONT PHYSIOL

SN - 1664-042X

M1 - 806366

ER -