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Baseline HV-interval predicts complete AV-block secondary to transcatheter aortic valve implantation

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Baseline HV-interval predicts complete AV-block secondary to transcatheter aortic valve implantation. / Shin, Dong-In; Merx, Marc W; Meyer, Christian; Kirmanoglou, Kiriakos; Hellhammer, Katharina; Ohlig, Jan; Katsani, Dimitra; Zeus, Tobias; Westenfeld, Ralf; Eickholt, Christian; Linke, Axel; Kelm, Malte.

In: ACTA CARDIOL, Vol. 70, No. 5, 10.2015, p. 574-580.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Shin, D-I, Merx, MW, Meyer, C, Kirmanoglou, K, Hellhammer, K, Ohlig, J, Katsani, D, Zeus, T, Westenfeld, R, Eickholt, C, Linke, A & Kelm, M 2015, 'Baseline HV-interval predicts complete AV-block secondary to transcatheter aortic valve implantation', ACTA CARDIOL, vol. 70, no. 5, pp. 574-580. https://doi.org/10.2143/AC.70.5.3110518

APA

Shin, D-I., Merx, M. W., Meyer, C., Kirmanoglou, K., Hellhammer, K., Ohlig, J., Katsani, D., Zeus, T., Westenfeld, R., Eickholt, C., Linke, A., & Kelm, M. (2015). Baseline HV-interval predicts complete AV-block secondary to transcatheter aortic valve implantation. ACTA CARDIOL, 70(5), 574-580. https://doi.org/10.2143/AC.70.5.3110518

Vancouver

Shin D-I, Merx MW, Meyer C, Kirmanoglou K, Hellhammer K, Ohlig J et al. Baseline HV-interval predicts complete AV-block secondary to transcatheter aortic valve implantation. ACTA CARDIOL. 2015 Oct;70(5):574-580. https://doi.org/10.2143/AC.70.5.3110518

Bibtex

@article{1f735c950cb24dff9a934074f637a02e,
title = "Baseline HV-interval predicts complete AV-block secondary to transcatheter aortic valve implantation",
abstract = "PURPOSE: Development of AV-block is a frequent complication associated with transcatheter aortic valve implantation (TAVI). To date little is known about the predictive value of the HV-interval prior to TAVI with respect to the risk of AV-block development.METHODS AND RESULTS: HV-interval was determined in 25 consecutive elderly patients with severe aortic valve stenosis (AS) before and immediately after TAVI. All patients subsequently underwent TAVI and 8 of these 25 patients (32%) developed complete AV-block during the TAVI procedure requiring permanent pacemaker implantation. Six of these 8 patients (75%) had marked HV prolongation (>54 ms). Pre-procedural HV-interval was significantly prolonged in the subgroup developing complete AV-block (62.1 ms±13.0 vs 49.2 ms±12.9; P=0.029). Prolongation of the HV-interval above 54 ms was associated with a higher rate of complete AV-block (sensitivity 75.0%, specificity 77.8%, P=0.01).CONCLUSIONS: HV-interval was prolonged in approximately one third of our elderly patients with aortic valve stenosis and associated with a high rate of complete AV-block following TAVI. HV-interval is easily obtained during TAVI screening procedures, thus facilitating identification of patients at risk for complete AV-block due to TAVI and consequently enabling bespoke risk management.",
keywords = "Aged, Aortic Valve/physiopathology, Aortic Valve Stenosis/complications, Arrhythmias, Cardiac/complications, Atrioventricular Block/diagnosis, Cardiac Catheterization/adverse effects, Cardiac Pacing, Artificial, Female, Heart Conduction System/physiopathology, Heart Rate, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation/adverse effects, Humans, Male, Middle Aged, Patient Selection, Predictive Value of Tests, Prosthesis Design, Risk Assessment, Risk Factors, Treatment Outcome",
author = "Dong-In Shin and Merx, {Marc W} and Christian Meyer and Kiriakos Kirmanoglou and Katharina Hellhammer and Jan Ohlig and Dimitra Katsani and Tobias Zeus and Ralf Westenfeld and Christian Eickholt and Axel Linke and Malte Kelm",
year = "2015",
month = oct,
doi = "10.2143/AC.70.5.3110518",
language = "English",
volume = "70",
pages = "574--580",
journal = "ACTA CARDIOL",
issn = "0001-5385",
publisher = "Acta Cardiologica",
number = "5",

}

RIS

TY - JOUR

T1 - Baseline HV-interval predicts complete AV-block secondary to transcatheter aortic valve implantation

AU - Shin, Dong-In

AU - Merx, Marc W

AU - Meyer, Christian

AU - Kirmanoglou, Kiriakos

AU - Hellhammer, Katharina

AU - Ohlig, Jan

AU - Katsani, Dimitra

AU - Zeus, Tobias

AU - Westenfeld, Ralf

AU - Eickholt, Christian

AU - Linke, Axel

AU - Kelm, Malte

PY - 2015/10

Y1 - 2015/10

N2 - PURPOSE: Development of AV-block is a frequent complication associated with transcatheter aortic valve implantation (TAVI). To date little is known about the predictive value of the HV-interval prior to TAVI with respect to the risk of AV-block development.METHODS AND RESULTS: HV-interval was determined in 25 consecutive elderly patients with severe aortic valve stenosis (AS) before and immediately after TAVI. All patients subsequently underwent TAVI and 8 of these 25 patients (32%) developed complete AV-block during the TAVI procedure requiring permanent pacemaker implantation. Six of these 8 patients (75%) had marked HV prolongation (>54 ms). Pre-procedural HV-interval was significantly prolonged in the subgroup developing complete AV-block (62.1 ms±13.0 vs 49.2 ms±12.9; P=0.029). Prolongation of the HV-interval above 54 ms was associated with a higher rate of complete AV-block (sensitivity 75.0%, specificity 77.8%, P=0.01).CONCLUSIONS: HV-interval was prolonged in approximately one third of our elderly patients with aortic valve stenosis and associated with a high rate of complete AV-block following TAVI. HV-interval is easily obtained during TAVI screening procedures, thus facilitating identification of patients at risk for complete AV-block due to TAVI and consequently enabling bespoke risk management.

AB - PURPOSE: Development of AV-block is a frequent complication associated with transcatheter aortic valve implantation (TAVI). To date little is known about the predictive value of the HV-interval prior to TAVI with respect to the risk of AV-block development.METHODS AND RESULTS: HV-interval was determined in 25 consecutive elderly patients with severe aortic valve stenosis (AS) before and immediately after TAVI. All patients subsequently underwent TAVI and 8 of these 25 patients (32%) developed complete AV-block during the TAVI procedure requiring permanent pacemaker implantation. Six of these 8 patients (75%) had marked HV prolongation (>54 ms). Pre-procedural HV-interval was significantly prolonged in the subgroup developing complete AV-block (62.1 ms±13.0 vs 49.2 ms±12.9; P=0.029). Prolongation of the HV-interval above 54 ms was associated with a higher rate of complete AV-block (sensitivity 75.0%, specificity 77.8%, P=0.01).CONCLUSIONS: HV-interval was prolonged in approximately one third of our elderly patients with aortic valve stenosis and associated with a high rate of complete AV-block following TAVI. HV-interval is easily obtained during TAVI screening procedures, thus facilitating identification of patients at risk for complete AV-block due to TAVI and consequently enabling bespoke risk management.

KW - Aged

KW - Aortic Valve/physiopathology

KW - Aortic Valve Stenosis/complications

KW - Arrhythmias, Cardiac/complications

KW - Atrioventricular Block/diagnosis

KW - Cardiac Catheterization/adverse effects

KW - Cardiac Pacing, Artificial

KW - Female

KW - Heart Conduction System/physiopathology

KW - Heart Rate

KW - Heart Valve Prosthesis

KW - Heart Valve Prosthesis Implantation/adverse effects

KW - Humans

KW - Male

KW - Middle Aged

KW - Patient Selection

KW - Predictive Value of Tests

KW - Prosthesis Design

KW - Risk Assessment

KW - Risk Factors

KW - Treatment Outcome

U2 - 10.2143/AC.70.5.3110518

DO - 10.2143/AC.70.5.3110518

M3 - SCORING: Journal article

C2 - 26567817

VL - 70

SP - 574

EP - 580

JO - ACTA CARDIOL

JF - ACTA CARDIOL

SN - 0001-5385

IS - 5

ER -