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Baseline anemia and its impact on midterm outcome after transcatheter aortic valve implantation

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Baseline anemia and its impact on midterm outcome after transcatheter aortic valve implantation. / Seiffert, Moritz; Conradi, Lenard; Gutwein, Andreas; Schön, Gerhard; Deuschl, Florian; Schofer, Niklas; Becker, Nina; Schirmer, Johannes; Reichenspurner, Hermann; Blankenberg, Stefan; Treede, Hendrik; Schäfer, Ulrich.

In: CATHETER CARDIO INTE, Vol. 89, No. 1, 01.2017, p. E44-E52.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Seiffert, M, Conradi, L, Gutwein, A, Schön, G, Deuschl, F, Schofer, N, Becker, N, Schirmer, J, Reichenspurner, H, Blankenberg, S, Treede, H & Schäfer, U 2017, 'Baseline anemia and its impact on midterm outcome after transcatheter aortic valve implantation', CATHETER CARDIO INTE, vol. 89, no. 1, pp. E44-E52. https://doi.org/10.1002/ccd.26563

APA

Seiffert, M., Conradi, L., Gutwein, A., Schön, G., Deuschl, F., Schofer, N., Becker, N., Schirmer, J., Reichenspurner, H., Blankenberg, S., Treede, H., & Schäfer, U. (2017). Baseline anemia and its impact on midterm outcome after transcatheter aortic valve implantation. CATHETER CARDIO INTE, 89(1), E44-E52. https://doi.org/10.1002/ccd.26563

Vancouver

Seiffert M, Conradi L, Gutwein A, Schön G, Deuschl F, Schofer N et al. Baseline anemia and its impact on midterm outcome after transcatheter aortic valve implantation. CATHETER CARDIO INTE. 2017 Jan;89(1):E44-E52. https://doi.org/10.1002/ccd.26563

Bibtex

@article{3e1bacc0f9124a5dabc73c5364e77897,
title = "Baseline anemia and its impact on midterm outcome after transcatheter aortic valve implantation",
abstract = "BACKGROUND: Anemia is linked to impaired outcome in patients with cardiovascular diseases. We sought to characterize the impact of baseline anemia on mid-term outcome after transcatheter aortic valve implantation (TAVI).METHODS AND RESULTS: Data of 1201 consecutive TAVI patients were retrospectively analyzed. Baseline anemia was defined according to the WHO (hemoglobin <12g/dl [female], <13g/dl [male]). It was prevalent in 59.0% of patients and associated with a higher preoperative risk (STS-PROM 7.8 ± 5.7 vs. 6.2 ± 4.1%, P < 0.001). Survival was similar at 30 days (90.5 vs. 91.2%, P = 0.626) but NYHA functional capacity was impaired in patients with baseline anemia (classes III/IV: 20.6 vs. 15.6%, P = 0.006). Low baseline hemoglobin (OR 0.85, CI 0.73-0.98, P = 0.025), blood transfusion (OR 2.42, CI 1.38-4.28, P = 0.002), and bleeding complications (OR 2.21, CI 1.27-3.81, P = 0.005) were in addition associated with acute kidney injury after TAVI. Three-year survival was reduced (49.6 vs. 64.9%, P = 0.002) and baseline anemia was linked to increased mid-term mortality (HR 1.43, CI 1.13-1.82, P = 0.003), however its effect was surpassed by the adverse impact of periprocedural complications.CONCLUSIONS: Baseline anemia was associated with increased morbidity and mortality after TAVI. Preprocedural hemoglobin levels need to be assessed for risk stratification and blood conservation management seems essential. As a potentially modifiable target, the role of pretreatment of anemia prior to TAVI remains to be determined. ",
author = "Moritz Seiffert and Lenard Conradi and Andreas Gutwein and Gerhard Sch{\"o}n and Florian Deuschl and Niklas Schofer and Nina Becker and Johannes Schirmer and Hermann Reichenspurner and Stefan Blankenberg and Hendrik Treede and Ulrich Sch{\"a}fer",
note = "{\textcopyright} 2016 Wiley Periodicals, Inc.",
year = "2017",
month = jan,
doi = "10.1002/ccd.26563",
language = "English",
volume = "89",
pages = "E44--E52",
journal = "CATHETER CARDIO INTE",
issn = "1522-1946",
publisher = "Wiley-Liss Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Baseline anemia and its impact on midterm outcome after transcatheter aortic valve implantation

AU - Seiffert, Moritz

AU - Conradi, Lenard

AU - Gutwein, Andreas

AU - Schön, Gerhard

AU - Deuschl, Florian

AU - Schofer, Niklas

AU - Becker, Nina

AU - Schirmer, Johannes

AU - Reichenspurner, Hermann

AU - Blankenberg, Stefan

AU - Treede, Hendrik

AU - Schäfer, Ulrich

N1 - © 2016 Wiley Periodicals, Inc.

PY - 2017/1

Y1 - 2017/1

N2 - BACKGROUND: Anemia is linked to impaired outcome in patients with cardiovascular diseases. We sought to characterize the impact of baseline anemia on mid-term outcome after transcatheter aortic valve implantation (TAVI).METHODS AND RESULTS: Data of 1201 consecutive TAVI patients were retrospectively analyzed. Baseline anemia was defined according to the WHO (hemoglobin <12g/dl [female], <13g/dl [male]). It was prevalent in 59.0% of patients and associated with a higher preoperative risk (STS-PROM 7.8 ± 5.7 vs. 6.2 ± 4.1%, P < 0.001). Survival was similar at 30 days (90.5 vs. 91.2%, P = 0.626) but NYHA functional capacity was impaired in patients with baseline anemia (classes III/IV: 20.6 vs. 15.6%, P = 0.006). Low baseline hemoglobin (OR 0.85, CI 0.73-0.98, P = 0.025), blood transfusion (OR 2.42, CI 1.38-4.28, P = 0.002), and bleeding complications (OR 2.21, CI 1.27-3.81, P = 0.005) were in addition associated with acute kidney injury after TAVI. Three-year survival was reduced (49.6 vs. 64.9%, P = 0.002) and baseline anemia was linked to increased mid-term mortality (HR 1.43, CI 1.13-1.82, P = 0.003), however its effect was surpassed by the adverse impact of periprocedural complications.CONCLUSIONS: Baseline anemia was associated with increased morbidity and mortality after TAVI. Preprocedural hemoglobin levels need to be assessed for risk stratification and blood conservation management seems essential. As a potentially modifiable target, the role of pretreatment of anemia prior to TAVI remains to be determined.

AB - BACKGROUND: Anemia is linked to impaired outcome in patients with cardiovascular diseases. We sought to characterize the impact of baseline anemia on mid-term outcome after transcatheter aortic valve implantation (TAVI).METHODS AND RESULTS: Data of 1201 consecutive TAVI patients were retrospectively analyzed. Baseline anemia was defined according to the WHO (hemoglobin <12g/dl [female], <13g/dl [male]). It was prevalent in 59.0% of patients and associated with a higher preoperative risk (STS-PROM 7.8 ± 5.7 vs. 6.2 ± 4.1%, P < 0.001). Survival was similar at 30 days (90.5 vs. 91.2%, P = 0.626) but NYHA functional capacity was impaired in patients with baseline anemia (classes III/IV: 20.6 vs. 15.6%, P = 0.006). Low baseline hemoglobin (OR 0.85, CI 0.73-0.98, P = 0.025), blood transfusion (OR 2.42, CI 1.38-4.28, P = 0.002), and bleeding complications (OR 2.21, CI 1.27-3.81, P = 0.005) were in addition associated with acute kidney injury after TAVI. Three-year survival was reduced (49.6 vs. 64.9%, P = 0.002) and baseline anemia was linked to increased mid-term mortality (HR 1.43, CI 1.13-1.82, P = 0.003), however its effect was surpassed by the adverse impact of periprocedural complications.CONCLUSIONS: Baseline anemia was associated with increased morbidity and mortality after TAVI. Preprocedural hemoglobin levels need to be assessed for risk stratification and blood conservation management seems essential. As a potentially modifiable target, the role of pretreatment of anemia prior to TAVI remains to be determined.

U2 - 10.1002/ccd.26563

DO - 10.1002/ccd.26563

M3 - SCORING: Journal article

C2 - 27142257

VL - 89

SP - E44-E52

JO - CATHETER CARDIO INTE

JF - CATHETER CARDIO INTE

SN - 1522-1946

IS - 1

ER -