Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions
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Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions. / Jockenhöfer, Finja; Gollnick, Harald; Herberger, Katharina; Isbary, Georg; Renner, Regina; Stücker, Markus; Valesky, Eva; Wollina, Uwe; Weichenthal, Michael; Karrer, Sigrid; Klode, Joachim; Dissemond, Joachim.
In: J DTSCH DERMATOL GES, Vol. 11, No. 11, 01.11.2013, p. 1057-63.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions
AU - Jockenhöfer, Finja
AU - Gollnick, Harald
AU - Herberger, Katharina
AU - Isbary, Georg
AU - Renner, Regina
AU - Stücker, Markus
AU - Valesky, Eva
AU - Wollina, Uwe
AU - Weichenthal, Michael
AU - Karrer, Sigrid
AU - Klode, Joachim
AU - Dissemond, Joachim
N1 - © The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.
PY - 2013/11/1
Y1 - 2013/11/1
N2 - BACKGROUND: In almost every chronic wound different bacteria species can be detected.PATIENTS AND METHODS: Retrospective, multicenter evaluation of bacterial swab results from 2010 and 2011 in patients with chronic leg ulcer treated in 10 dermatologic wound care centers from 5 regions in Germany.RESULTS: Data of 970 patients were analyzed. Staphylococcus aureus was detected in 47.6 % of the patients, 8.6% of these were methicillin-resistant (MRSA). Pseudomonas aeruginosa was found in 31.1 %, enterobacteria in 28.6 % and Proteus mirabilis in 13.7 % of the patients. The regional comparison showed a significant south-north gradient for S. aureus, P. aeruginosa, and enterobacteria. Moreover, a highly significant west-east gradient for MRSA was found with detection rates of 13.5 % in the west to 4.0 % in the east. Furthermore, nationally there was a significant negative correlation between S. aureus and P. aeruginosa or P. mirabilis, respectively, as well as a positive correlation of P. aeruginosa with respect to wound size and duration. In addition to climatic and therapeutic conditions, different regional health care structures are discussed as potentially relevant reasons for these significantly different regional detection rates.CONCLUSIONS: Our data show the regional variability of the spectrum of currently detected bacteria in patients with chronic leg ulcers in Germany.
AB - BACKGROUND: In almost every chronic wound different bacteria species can be detected.PATIENTS AND METHODS: Retrospective, multicenter evaluation of bacterial swab results from 2010 and 2011 in patients with chronic leg ulcer treated in 10 dermatologic wound care centers from 5 regions in Germany.RESULTS: Data of 970 patients were analyzed. Staphylococcus aureus was detected in 47.6 % of the patients, 8.6% of these were methicillin-resistant (MRSA). Pseudomonas aeruginosa was found in 31.1 %, enterobacteria in 28.6 % and Proteus mirabilis in 13.7 % of the patients. The regional comparison showed a significant south-north gradient for S. aureus, P. aeruginosa, and enterobacteria. Moreover, a highly significant west-east gradient for MRSA was found with detection rates of 13.5 % in the west to 4.0 % in the east. Furthermore, nationally there was a significant negative correlation between S. aureus and P. aeruginosa or P. mirabilis, respectively, as well as a positive correlation of P. aeruginosa with respect to wound size and duration. In addition to climatic and therapeutic conditions, different regional health care structures are discussed as potentially relevant reasons for these significantly different regional detection rates.CONCLUSIONS: Our data show the regional variability of the spectrum of currently detected bacteria in patients with chronic leg ulcers in Germany.
U2 - 10.1111/ddg.12170
DO - 10.1111/ddg.12170
M3 - SCORING: Journal article
C2 - 23945189
VL - 11
SP - 1057
EP - 1063
JO - J DTSCH DERMATOL GES
JF - J DTSCH DERMATOL GES
SN - 1610-0379
IS - 11
ER -