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Bacterial type III secretion Systems: specialized nanomachines for protein delivery into target cells

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Bacterial type III secretion Systems: specialized nanomachines for protein delivery into target cells. / Galán, Jorge E; Lara-Tejero, Maria; Marlovits, Thomas C; Wagner, Samuel.

In: ANNU REV MICROBIOL, Vol. 68, 01.01.2014, p. 415-38.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Galán, JE, Lara-Tejero, M, Marlovits, TC & Wagner, S 2014, 'Bacterial type III secretion Systems: specialized nanomachines for protein delivery into target cells', ANNU REV MICROBIOL, vol. 68, pp. 415-38. https://doi.org/10.1146/annurev-micro-092412-155725

APA

Galán, J. E., Lara-Tejero, M., Marlovits, T. C., & Wagner, S. (2014). Bacterial type III secretion Systems: specialized nanomachines for protein delivery into target cells. ANNU REV MICROBIOL, 68, 415-38. https://doi.org/10.1146/annurev-micro-092412-155725

Vancouver

Galán JE, Lara-Tejero M, Marlovits TC, Wagner S. Bacterial type III secretion Systems: specialized nanomachines for protein delivery into target cells. ANNU REV MICROBIOL. 2014 Jan 1;68:415-38. https://doi.org/10.1146/annurev-micro-092412-155725

Bibtex

@article{5580aaba54cc4607b466eb4009c6a1f6,
title = "Bacterial type III secretion Systems: specialized nanomachines for protein delivery into target cells",
abstract = "One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into target eukaryotic cells. These effector proteins modulate a variety of cellular functions for the pathogen's benefit. One of these protein-delivery machines is the type III secretion system (T3SS). T3SSs are widespread in nature and are encoded not only by bacteria pathogenic to vertebrates or plants but also by bacteria that are symbiotic to plants or insects. A central component of T3SSs is the needle complex, a supramolecular structure that mediates the passage of the secreted proteins across the bacterial envelope. Working in conjunction with several cytoplasmic components, the needle complex engages specific substrates in sequential order, moves them across the bacterial envelope, and ultimately delivers them into eukaryotic cells. The central role of T3SSs in pathogenesis makes them great targets for novel antimicrobial strategies.",
author = "Gal{\'a}n, {Jorge E} and Maria Lara-Tejero and Marlovits, {Thomas C} and Samuel Wagner",
year = "2014",
month = jan,
day = "1",
doi = "10.1146/annurev-micro-092412-155725",
language = "English",
volume = "68",
pages = "415--38",
journal = "ANNU REV MICROBIOL",
issn = "0066-4227",
publisher = "Annual Reviews Inc.",

}

RIS

TY - JOUR

T1 - Bacterial type III secretion Systems: specialized nanomachines for protein delivery into target cells

AU - Galán, Jorge E

AU - Lara-Tejero, Maria

AU - Marlovits, Thomas C

AU - Wagner, Samuel

PY - 2014/1/1

Y1 - 2014/1/1

N2 - One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into target eukaryotic cells. These effector proteins modulate a variety of cellular functions for the pathogen's benefit. One of these protein-delivery machines is the type III secretion system (T3SS). T3SSs are widespread in nature and are encoded not only by bacteria pathogenic to vertebrates or plants but also by bacteria that are symbiotic to plants or insects. A central component of T3SSs is the needle complex, a supramolecular structure that mediates the passage of the secreted proteins across the bacterial envelope. Working in conjunction with several cytoplasmic components, the needle complex engages specific substrates in sequential order, moves them across the bacterial envelope, and ultimately delivers them into eukaryotic cells. The central role of T3SSs in pathogenesis makes them great targets for novel antimicrobial strategies.

AB - One of the most exciting developments in the field of bacterial pathogenesis in recent years is the discovery that many pathogens utilize complex nanomachines to deliver bacterially encoded effector proteins into target eukaryotic cells. These effector proteins modulate a variety of cellular functions for the pathogen's benefit. One of these protein-delivery machines is the type III secretion system (T3SS). T3SSs are widespread in nature and are encoded not only by bacteria pathogenic to vertebrates or plants but also by bacteria that are symbiotic to plants or insects. A central component of T3SSs is the needle complex, a supramolecular structure that mediates the passage of the secreted proteins across the bacterial envelope. Working in conjunction with several cytoplasmic components, the needle complex engages specific substrates in sequential order, moves them across the bacterial envelope, and ultimately delivers them into eukaryotic cells. The central role of T3SSs in pathogenesis makes them great targets for novel antimicrobial strategies.

U2 - 10.1146/annurev-micro-092412-155725

DO - 10.1146/annurev-micro-092412-155725

M3 - SCORING: Journal article

C2 - 25002086

VL - 68

SP - 415

EP - 438

JO - ANNU REV MICROBIOL

JF - ANNU REV MICROBIOL

SN - 0066-4227

ER -