Babies Galore; or recent findings and future perspectives of pregnancy cohorts with a focus on immunity
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Babies Galore; or recent findings and future perspectives of pregnancy cohorts with a focus on immunity. / Hartwig, Isabel; Diemert, Anke; Tolosa, Eva; Hecher, Kurt; Arck, Petra.
In: J REPROD IMMUNOL, Vol. 108, 01.04.2015, p. 6-11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Babies Galore; or recent findings and future perspectives of pregnancy cohorts with a focus on immunity
AU - Hartwig, Isabel
AU - Diemert, Anke
AU - Tolosa, Eva
AU - Hecher, Kurt
AU - Arck, Petra
N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Population-based pregnancy cohorts recruiting women before or at the moment of childbirth allow a longitudinal follow-up on children's health later in life. Important findings arising from pregnancy cohorts are discussed in the present review. These insights have led to revised guidelines on how to minimize disease risks in children, e.g., in the context of chronic immune diseases including allergies and asthma. Moreover, insights from pregnancy cohorts also unveiled a collateral effect of pregnancy on maternal immunity, mirrored by an ameliorated course of certain autoimmune diseases, but also an increased risk of infection with influenza A virus. Future pregnancy cohort studies are still required to close gaps in knowledge on how parameters involved in the developmental origin of health or poor immunity observed in children later in life are operational. We discuss here features that should be covered by future pregnancy cohort studies. Expected insights from such studies will then lay the foundation for biomarker discovery and offer opportunities for interventions to ameliorate adverse immune responses in humans.
AB - Population-based pregnancy cohorts recruiting women before or at the moment of childbirth allow a longitudinal follow-up on children's health later in life. Important findings arising from pregnancy cohorts are discussed in the present review. These insights have led to revised guidelines on how to minimize disease risks in children, e.g., in the context of chronic immune diseases including allergies and asthma. Moreover, insights from pregnancy cohorts also unveiled a collateral effect of pregnancy on maternal immunity, mirrored by an ameliorated course of certain autoimmune diseases, but also an increased risk of infection with influenza A virus. Future pregnancy cohort studies are still required to close gaps in knowledge on how parameters involved in the developmental origin of health or poor immunity observed in children later in life are operational. We discuss here features that should be covered by future pregnancy cohort studies. Expected insights from such studies will then lay the foundation for biomarker discovery and offer opportunities for interventions to ameliorate adverse immune responses in humans.
U2 - 10.1016/j.jri.2015.01.001
DO - 10.1016/j.jri.2015.01.001
M3 - SCORING: Journal article
C2 - 25639271
VL - 108
SP - 6
EP - 11
JO - J REPROD IMMUNOL
JF - J REPROD IMMUNOL
SN - 0165-0378
ER -