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B cells in autoimmune hepatitis: bystanders or central players?

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B cells in autoimmune hepatitis: bystanders or central players? / Schultheiß, Christoph; Steinmann, Silja; Lohse, Ansgar W; Binder, Mascha.

In: SEMIN IMMUNOPATHOL, Vol. 44, No. 4, 07.2022, p. 411-427.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Schultheiß, C, Steinmann, S, Lohse, AW & Binder, M 2022, 'B cells in autoimmune hepatitis: bystanders or central players?', SEMIN IMMUNOPATHOL, vol. 44, no. 4, pp. 411-427. https://doi.org/10.1007/s00281-022-00937-5

APA

Schultheiß, C., Steinmann, S., Lohse, A. W., & Binder, M. (2022). B cells in autoimmune hepatitis: bystanders or central players? SEMIN IMMUNOPATHOL, 44(4), 411-427. https://doi.org/10.1007/s00281-022-00937-5

Vancouver

Schultheiß C, Steinmann S, Lohse AW, Binder M. B cells in autoimmune hepatitis: bystanders or central players? SEMIN IMMUNOPATHOL. 2022 Jul;44(4):411-427. https://doi.org/10.1007/s00281-022-00937-5

Bibtex

@article{d7239a8ab3c0412291ec711e9abcdebd,
title = "B cells in autoimmune hepatitis: bystanders or central players?",
abstract = "B cells are central for the adaptive immune system to mount successful immune responses not only as antibody producers but also as regulators of cellular immunity. These multifaceted features are also reflected in autoimmunity where autoreactive B cells can fuel disease by production of cytotoxic autoantibodies, presentation of autoantigens to autoreactive T cells, and secretion of cytokines and chemokines that either promote detrimental immune activation or impair regulatory T and B cells. The role of B cells and autoantibodies in autoimmune hepatitis (AIH) have been controversially discussed, with typical autoantibodies and hypergammaglobulinemia indicating a key role, while strong HLA class II association suggests T cells as key players. In this review, we summarize current knowledge on B cells in AIH and how different B cell subpopulations may drive AIH progression beyond autoantibodies. We also discuss recent findings of B cell-directed therapies in AIH.",
author = "Christoph Schulthei{\ss} and Silja Steinmann and Lohse, {Ansgar W} and Mascha Binder",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = jul,
doi = "10.1007/s00281-022-00937-5",
language = "English",
volume = "44",
pages = "411--427",
journal = "SEMIN IMMUNOPATHOL",
issn = "1863-2297",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - B cells in autoimmune hepatitis: bystanders or central players?

AU - Schultheiß, Christoph

AU - Steinmann, Silja

AU - Lohse, Ansgar W

AU - Binder, Mascha

N1 - © 2022. The Author(s).

PY - 2022/7

Y1 - 2022/7

N2 - B cells are central for the adaptive immune system to mount successful immune responses not only as antibody producers but also as regulators of cellular immunity. These multifaceted features are also reflected in autoimmunity where autoreactive B cells can fuel disease by production of cytotoxic autoantibodies, presentation of autoantigens to autoreactive T cells, and secretion of cytokines and chemokines that either promote detrimental immune activation or impair regulatory T and B cells. The role of B cells and autoantibodies in autoimmune hepatitis (AIH) have been controversially discussed, with typical autoantibodies and hypergammaglobulinemia indicating a key role, while strong HLA class II association suggests T cells as key players. In this review, we summarize current knowledge on B cells in AIH and how different B cell subpopulations may drive AIH progression beyond autoantibodies. We also discuss recent findings of B cell-directed therapies in AIH.

AB - B cells are central for the adaptive immune system to mount successful immune responses not only as antibody producers but also as regulators of cellular immunity. These multifaceted features are also reflected in autoimmunity where autoreactive B cells can fuel disease by production of cytotoxic autoantibodies, presentation of autoantigens to autoreactive T cells, and secretion of cytokines and chemokines that either promote detrimental immune activation or impair regulatory T and B cells. The role of B cells and autoantibodies in autoimmune hepatitis (AIH) have been controversially discussed, with typical autoantibodies and hypergammaglobulinemia indicating a key role, while strong HLA class II association suggests T cells as key players. In this review, we summarize current knowledge on B cells in AIH and how different B cell subpopulations may drive AIH progression beyond autoantibodies. We also discuss recent findings of B cell-directed therapies in AIH.

U2 - 10.1007/s00281-022-00937-5

DO - 10.1007/s00281-022-00937-5

M3 - SCORING: Review article

C2 - 35488094

VL - 44

SP - 411

EP - 427

JO - SEMIN IMMUNOPATHOL

JF - SEMIN IMMUNOPATHOL

SN - 1863-2297

IS - 4

ER -