Avascular mandibular osteonecrosis in association with bisphosphonate therapy: a report on four patients.
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Avascular mandibular osteonecrosis in association with bisphosphonate therapy: a report on four patients. / Friedrich, Reinhard; Blake, Felix.
In: ANTICANCER RES, Vol. 27, No. 4, 4, 2007, p. 1841-1845.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Avascular mandibular osteonecrosis in association with bisphosphonate therapy: a report on four patients.
AU - Friedrich, Reinhard
AU - Blake, Felix
PY - 2007
Y1 - 2007
N2 - Over the past three years, several reports have been published on jaw osteonecrosis possibly being associated with the administration of bisphosphonates. Bisphosphonates are highly active inhibitors of osteoclasts. These drugs are used for the treatment of multiple myeloma, bone resorption in the case of metastatic malignant diseases, tumor-associated hypercalcaemia, and in the treatment of osteoporosis. Due to the importance of this presumed side-effect of bisphosphonates for the dentist and the maxillofacial surgeon, we report four cases. CASE REPORTS: Four patients (two women and two men aged 56, 62, 67 and 75 years, respectively) were diagnosed with osteonecrosis of the mandible. These osteonecroses did not react adequately to local treatment and systemic therapy with antibiotics. One patient suffered from non-Hodgkin's lymphoma, one from breast cancer, one from prostate cancer and one from sarcoidosis. Besides cytostatic chemotherapies, all patients received bisphosphonates over an extended period. DISCUSSION: Bisphosphonates are considered an established standard in the treatment of multiple myeloma and bone metastases. Over the past few years, a rapidly increasing number of reports have been published describing patients with a history of bisphosphonate therapy in whom therapy-resistant osteonecrosis of jaw bones occurred either after dental extractions or spontaneously. Since then, bisphosphonate therapy has come under scrutiny as a cause of osteonecrosis. However, the multiplicity of drugs prescribed for the treatment of cancer requires caution when determining a cause-and-action effect. Since patients with malignant diseases receive cytostatic therapy and a range of other drugs, including bisphosphonates, enhancement of the side-effects may be presumed. The case report of an osteonecrosis of the jaw following multi-drug therapy for sarcoidosis adds a further and non-cancerous condition to the newly described entity of bisphosphonate-associated jaw necrosis. CONCLUSION: The probable association of the therapeutic use of bisphosphonates and the development of jaw necrosis has to be studied in further investigations. Patients who will undergo bisphosphonate therapy should receive a careful dental check-up prior to drug application. Patients receiving bisphosphonates should be followed up carefully to avoid the occurrence of extended osteonecrotic lesions. Moreover, established jaw lesions must be diagnosed precisely in order to exclude metastatic disease.
AB - Over the past three years, several reports have been published on jaw osteonecrosis possibly being associated with the administration of bisphosphonates. Bisphosphonates are highly active inhibitors of osteoclasts. These drugs are used for the treatment of multiple myeloma, bone resorption in the case of metastatic malignant diseases, tumor-associated hypercalcaemia, and in the treatment of osteoporosis. Due to the importance of this presumed side-effect of bisphosphonates for the dentist and the maxillofacial surgeon, we report four cases. CASE REPORTS: Four patients (two women and two men aged 56, 62, 67 and 75 years, respectively) were diagnosed with osteonecrosis of the mandible. These osteonecroses did not react adequately to local treatment and systemic therapy with antibiotics. One patient suffered from non-Hodgkin's lymphoma, one from breast cancer, one from prostate cancer and one from sarcoidosis. Besides cytostatic chemotherapies, all patients received bisphosphonates over an extended period. DISCUSSION: Bisphosphonates are considered an established standard in the treatment of multiple myeloma and bone metastases. Over the past few years, a rapidly increasing number of reports have been published describing patients with a history of bisphosphonate therapy in whom therapy-resistant osteonecrosis of jaw bones occurred either after dental extractions or spontaneously. Since then, bisphosphonate therapy has come under scrutiny as a cause of osteonecrosis. However, the multiplicity of drugs prescribed for the treatment of cancer requires caution when determining a cause-and-action effect. Since patients with malignant diseases receive cytostatic therapy and a range of other drugs, including bisphosphonates, enhancement of the side-effects may be presumed. The case report of an osteonecrosis of the jaw following multi-drug therapy for sarcoidosis adds a further and non-cancerous condition to the newly described entity of bisphosphonate-associated jaw necrosis. CONCLUSION: The probable association of the therapeutic use of bisphosphonates and the development of jaw necrosis has to be studied in further investigations. Patients who will undergo bisphosphonate therapy should receive a careful dental check-up prior to drug application. Patients receiving bisphosphonates should be followed up carefully to avoid the occurrence of extended osteonecrotic lesions. Moreover, established jaw lesions must be diagnosed precisely in order to exclude metastatic disease.
KW - Aged
KW - Antineoplastic Agents
KW - Bone Density Conservation Agents
KW - Breast Neoplasms
KW - Diphosphonates
KW - Female
KW - Humans
KW - Lymphoma, Non-Hodgkin
KW - Male
KW - Mandibular Diseases
KW - Middle Aged
KW - Osteonecrosis
KW - Prostatic Neoplasms
KW - Sarcoidosis
M3 - SCORING: Journal article
C2 - 17649782
VL - 27
SP - 1841
EP - 1845
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 4
M1 - 4
ER -