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Automatic covariance pattern analysis outperforms visual reading of 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy

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Automatic covariance pattern analysis outperforms visual reading of 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy. / Buchert, Ralph; Wegner, Florian; Huppertz, Hans-Jürgen; Berding, Georg; Brendel, Matthias; Apostolova, Ivayla; Buhmann, Carsten; Dierks, Alexander; Katzdobler, Sabrina; Klietz, Martin; Levin, Johannes; Mahmoudi, Nima; Rinscheid, Andreas; Rogozinski, Sophia; Rumpf, Jost-Julian; Schneider, Christine; Stöcklein, Sophia; Spetsieris, Phoebe G; Eidelberg, David; Wattjes, Mike P; Sabri, Osama; Barthel, Henryk; Höglinger, Günter; Alzheimer’s Disease Neuroimaging Initiative.

In: MOVEMENT DISORD, Vol. 38, No. 10, 27.10.2023, p. 1901-1913.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Buchert, R, Wegner, F, Huppertz, H-J, Berding, G, Brendel, M, Apostolova, I, Buhmann, C, Dierks, A, Katzdobler, S, Klietz, M, Levin, J, Mahmoudi, N, Rinscheid, A, Rogozinski, S, Rumpf, J-J, Schneider, C, Stöcklein, S, Spetsieris, PG, Eidelberg, D, Wattjes, MP, Sabri, O, Barthel, H, Höglinger, G & Alzheimer’s Disease Neuroimaging Initiative 2023, 'Automatic covariance pattern analysis outperforms visual reading of 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy', MOVEMENT DISORD, vol. 38, no. 10, pp. 1901-1913. https://doi.org/10.1002/mds.29581

APA

Buchert, R., Wegner, F., Huppertz, H-J., Berding, G., Brendel, M., Apostolova, I., Buhmann, C., Dierks, A., Katzdobler, S., Klietz, M., Levin, J., Mahmoudi, N., Rinscheid, A., Rogozinski, S., Rumpf, J-J., Schneider, C., Stöcklein, S., Spetsieris, P. G., Eidelberg, D., ... Alzheimer’s Disease Neuroimaging Initiative (2023). Automatic covariance pattern analysis outperforms visual reading of 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy. MOVEMENT DISORD, 38(10), 1901-1913. https://doi.org/10.1002/mds.29581

Vancouver

Buchert R, Wegner F, Huppertz H-J, Berding G, Brendel M, Apostolova I et al. Automatic covariance pattern analysis outperforms visual reading of 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy. MOVEMENT DISORD. 2023 Oct 27;38(10):1901-1913. https://doi.org/10.1002/mds.29581

Bibtex

@article{9574232d0f794ae1a6bef7597f5b1379,
title = "Automatic covariance pattern analysis outperforms visual reading of 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy",
abstract = "BACKGROUND: To date, studies on positron emission tomography (PET) with 18 F-fluorodeoxyglucose (FDG) in progressive supranuclear palsy (PSP) usually included PSP cohorts overrepresenting patients with Richardson's syndrome (PSP-RS).OBJECTIVES: To evaluate FDG-PET in a patient sample representing the broad phenotypic PSP spectrum typically encountered in routine clinical practice.METHODS: This retrospective, multicenter study included 41 PSP patients, 21 (51%) with RS and 20 (49%) with non-RS variants of PSP (vPSP), and 46 age-matched healthy controls. Two state-of-the art methods for the interpretation of FDG-PET were compared: visual analysis supported by voxel-based statistical testing (five readers) and automatic covariance pattern analysis using a predefined PSP-related pattern.RESULTS: Sensitivity and specificity of the majority visual read for the detection of PSP in the whole cohort were 74% and 72%, respectively. The percentage of false-negative cases was 10% in the PSP-RS subsample and 43% in the vPSP subsample. Automatic covariance pattern analysis provided sensitivity and specificity of 93% and 83% in the whole cohort. The percentage of false-negative cases was 0% in the PSP-RS subsample and 15% in the vPSP subsample.CONCLUSIONS: Visual interpretation of FDG-PET supported by voxel-based testing provides good accuracy for the detection of PSP-RS, but only fair sensitivity for vPSP. Automatic covariance pattern analysis outperforms visual interpretation in the detection of PSP-RS, provides clinically useful sensitivity for vPSP, and reduces the rate of false-positive findings. Thus, pattern expression analysis is clinically useful to complement visual reading and voxel-based testing of FDG-PET in suspected PSP. {\textcopyright} 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.",
author = "Ralph Buchert and Florian Wegner and Hans-J{\"u}rgen Huppertz and Georg Berding and Matthias Brendel and Ivayla Apostolova and Carsten Buhmann and Alexander Dierks and Sabrina Katzdobler and Martin Klietz and Johannes Levin and Nima Mahmoudi and Andreas Rinscheid and Sophia Rogozinski and Jost-Julian Rumpf and Christine Schneider and Sophia St{\"o}cklein and Spetsieris, {Phoebe G} and David Eidelberg and Wattjes, {Mike P} and Osama Sabri and Henryk Barthel and G{\"u}nter H{\"o}glinger and {Alzheimer{\textquoteright}s Disease Neuroimaging Initiative}",
note = "{\textcopyright} 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.",
year = "2023",
month = oct,
day = "27",
doi = "10.1002/mds.29581",
language = "English",
volume = "38",
pages = "1901--1913",
journal = "MOVEMENT DISORD",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Automatic covariance pattern analysis outperforms visual reading of 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET) in variant progressive supranuclear palsy

AU - Buchert, Ralph

AU - Wegner, Florian

AU - Huppertz, Hans-Jürgen

AU - Berding, Georg

AU - Brendel, Matthias

AU - Apostolova, Ivayla

AU - Buhmann, Carsten

AU - Dierks, Alexander

AU - Katzdobler, Sabrina

AU - Klietz, Martin

AU - Levin, Johannes

AU - Mahmoudi, Nima

AU - Rinscheid, Andreas

AU - Rogozinski, Sophia

AU - Rumpf, Jost-Julian

AU - Schneider, Christine

AU - Stöcklein, Sophia

AU - Spetsieris, Phoebe G

AU - Eidelberg, David

AU - Wattjes, Mike P

AU - Sabri, Osama

AU - Barthel, Henryk

AU - Höglinger, Günter

AU - Alzheimer’s Disease Neuroimaging Initiative

N1 - © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

PY - 2023/10/27

Y1 - 2023/10/27

N2 - BACKGROUND: To date, studies on positron emission tomography (PET) with 18 F-fluorodeoxyglucose (FDG) in progressive supranuclear palsy (PSP) usually included PSP cohorts overrepresenting patients with Richardson's syndrome (PSP-RS).OBJECTIVES: To evaluate FDG-PET in a patient sample representing the broad phenotypic PSP spectrum typically encountered in routine clinical practice.METHODS: This retrospective, multicenter study included 41 PSP patients, 21 (51%) with RS and 20 (49%) with non-RS variants of PSP (vPSP), and 46 age-matched healthy controls. Two state-of-the art methods for the interpretation of FDG-PET were compared: visual analysis supported by voxel-based statistical testing (five readers) and automatic covariance pattern analysis using a predefined PSP-related pattern.RESULTS: Sensitivity and specificity of the majority visual read for the detection of PSP in the whole cohort were 74% and 72%, respectively. The percentage of false-negative cases was 10% in the PSP-RS subsample and 43% in the vPSP subsample. Automatic covariance pattern analysis provided sensitivity and specificity of 93% and 83% in the whole cohort. The percentage of false-negative cases was 0% in the PSP-RS subsample and 15% in the vPSP subsample.CONCLUSIONS: Visual interpretation of FDG-PET supported by voxel-based testing provides good accuracy for the detection of PSP-RS, but only fair sensitivity for vPSP. Automatic covariance pattern analysis outperforms visual interpretation in the detection of PSP-RS, provides clinically useful sensitivity for vPSP, and reduces the rate of false-positive findings. Thus, pattern expression analysis is clinically useful to complement visual reading and voxel-based testing of FDG-PET in suspected PSP. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

AB - BACKGROUND: To date, studies on positron emission tomography (PET) with 18 F-fluorodeoxyglucose (FDG) in progressive supranuclear palsy (PSP) usually included PSP cohorts overrepresenting patients with Richardson's syndrome (PSP-RS).OBJECTIVES: To evaluate FDG-PET in a patient sample representing the broad phenotypic PSP spectrum typically encountered in routine clinical practice.METHODS: This retrospective, multicenter study included 41 PSP patients, 21 (51%) with RS and 20 (49%) with non-RS variants of PSP (vPSP), and 46 age-matched healthy controls. Two state-of-the art methods for the interpretation of FDG-PET were compared: visual analysis supported by voxel-based statistical testing (five readers) and automatic covariance pattern analysis using a predefined PSP-related pattern.RESULTS: Sensitivity and specificity of the majority visual read for the detection of PSP in the whole cohort were 74% and 72%, respectively. The percentage of false-negative cases was 10% in the PSP-RS subsample and 43% in the vPSP subsample. Automatic covariance pattern analysis provided sensitivity and specificity of 93% and 83% in the whole cohort. The percentage of false-negative cases was 0% in the PSP-RS subsample and 15% in the vPSP subsample.CONCLUSIONS: Visual interpretation of FDG-PET supported by voxel-based testing provides good accuracy for the detection of PSP-RS, but only fair sensitivity for vPSP. Automatic covariance pattern analysis outperforms visual interpretation in the detection of PSP-RS, provides clinically useful sensitivity for vPSP, and reduces the rate of false-positive findings. Thus, pattern expression analysis is clinically useful to complement visual reading and voxel-based testing of FDG-PET in suspected PSP. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

U2 - 10.1002/mds.29581

DO - 10.1002/mds.29581

M3 - SCORING: Journal article

C2 - 37655363

VL - 38

SP - 1901

EP - 1913

JO - MOVEMENT DISORD

JF - MOVEMENT DISORD

SN - 0885-3185

IS - 10

ER -