Autologous stem cell transplantation for therapy-related acute myeloid leukemia and myelodysplastic syndrome.
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Autologous stem cell transplantation for therapy-related acute myeloid leukemia and myelodysplastic syndrome. / Kröger, Nicolaus; Brand, R; van Biezen, A; Cahn, J-Y; Slavin, S; Blaise, D; Sierra, J; Zander, Axel R.; Niederwieser, D; de Witte, T.
In: BONE MARROW TRANSPL, Vol. 37, No. 2, 2, 2006, p. 183-189.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Autologous stem cell transplantation for therapy-related acute myeloid leukemia and myelodysplastic syndrome.
AU - Kröger, Nicolaus
AU - Brand, R
AU - van Biezen, A
AU - Cahn, J-Y
AU - Slavin, S
AU - Blaise, D
AU - Sierra, J
AU - Zander, Axel R.
AU - Niederwieser, D
AU - de Witte, T
PY - 2006
Y1 - 2006
N2 - We report the results of 65 patients with treatment-related myelodysplastic syndrome (MDS)/acute myelogenous leukemia (AML) who were transplanted from an autograft and reported to the EBMT. The median age was 39 years (range, 3-69), and stem cell source was bone marrow (n = 31), or peripheral blood progenitor cells (n = 30), or the combination of both (n = 4). The primary disease was solid tumors (n = 37), Hodgkin's disease (n = 13), non-Hodgkin's lymphoma (n = 10), acute lymphoblastic leukemia (n = 2) or myeloproliferative syndromes (n = 3). The types of MDS were as follows: RAEB (n = 1; 2%), RAEB-t (n = 3; 5%), or AML (n = 56; 87%). The median time between diagnosis and transplantation was 5 months (range, 3-86). The Kaplan-Meier estimates of the probability of 3-year overall and disease-free survival were 35% (95% CI: 21-49%) and 32% (95% CI: 18-45%), respectively. The median leukocyte engraftment was faster after transplantation with peripheral blood stem cells than with bone marrow: 12 (range, 9-26) vs 29 (range, 11-67) days (P
AB - We report the results of 65 patients with treatment-related myelodysplastic syndrome (MDS)/acute myelogenous leukemia (AML) who were transplanted from an autograft and reported to the EBMT. The median age was 39 years (range, 3-69), and stem cell source was bone marrow (n = 31), or peripheral blood progenitor cells (n = 30), or the combination of both (n = 4). The primary disease was solid tumors (n = 37), Hodgkin's disease (n = 13), non-Hodgkin's lymphoma (n = 10), acute lymphoblastic leukemia (n = 2) or myeloproliferative syndromes (n = 3). The types of MDS were as follows: RAEB (n = 1; 2%), RAEB-t (n = 3; 5%), or AML (n = 56; 87%). The median time between diagnosis and transplantation was 5 months (range, 3-86). The Kaplan-Meier estimates of the probability of 3-year overall and disease-free survival were 35% (95% CI: 21-49%) and 32% (95% CI: 18-45%), respectively. The median leukocyte engraftment was faster after transplantation with peripheral blood stem cells than with bone marrow: 12 (range, 9-26) vs 29 (range, 11-67) days (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 37
SP - 183
EP - 189
JO - BONE MARROW TRANSPL
JF - BONE MARROW TRANSPL
SN - 0268-3369
IS - 2
M1 - 2
ER -