Autoimmunerkrankungen der Leber
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Autoimmunerkrankungen der Leber. / Pannicke, N; Schramm, C; Lohse, A W.
In: INTERNIST, Vol. 53, No. 8, 08.2012, p. 943-54; quiz 955-6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Autoimmunerkrankungen der Leber
AU - Pannicke, N
AU - Schramm, C
AU - Lohse, A W
PY - 2012/8
Y1 - 2012/8
N2 - Autoimmune liver diseases are divided into autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). They play an important role in the differential diagnosis of acute and chronic liver diseases. Diagnostic criteria consist of biochemical parameters (liver function tests, immunoglobulins, autoantibodies), imaging (ultrasound, MRCP, ERCP) and histopathologic characteristics. The treatment of choice in AIH is a combined immunosuppressive therapy of prednisolone and azathioprine. Ursodeoxycholic acid is the treatment of choice for PBC and improves liver biochemistry and prolongs transplant-free survival by slowing histological progression in the majority of patients. To date, there is no effective medical treatment option for patients with PSC.
AB - Autoimmune liver diseases are divided into autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). They play an important role in the differential diagnosis of acute and chronic liver diseases. Diagnostic criteria consist of biochemical parameters (liver function tests, immunoglobulins, autoantibodies), imaging (ultrasound, MRCP, ERCP) and histopathologic characteristics. The treatment of choice in AIH is a combined immunosuppressive therapy of prednisolone and azathioprine. Ursodeoxycholic acid is the treatment of choice for PBC and improves liver biochemistry and prolongs transplant-free survival by slowing histological progression in the majority of patients. To date, there is no effective medical treatment option for patients with PSC.
KW - Autoimmune Diseases
KW - Diagnosis, Differential
KW - Humans
KW - Liver Diseases
KW - English Abstract
KW - Journal Article
U2 - 10.1007/s00108-012-3096-4
DO - 10.1007/s00108-012-3096-4
M3 - SCORING: Zeitschriftenaufsatz
C2 - 22806149
VL - 53
SP - 943-54; quiz 955-6
JO - INTERNIST
JF - INTERNIST
SN - 0020-9554
IS - 8
ER -