Autoimmunerkrankungen der Leber

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Autoimmunerkrankungen der Leber. / Pannicke, N; Schramm, C; Lohse, A W.

In: INTERNIST, Vol. 53, No. 8, 08.2012, p. 943-54; quiz 955-6.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

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@article{c76dd26355544733a1662bbe6d322816,
title = "Autoimmunerkrankungen der Leber",
abstract = "Autoimmune liver diseases are divided into autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). They play an important role in the differential diagnosis of acute and chronic liver diseases. Diagnostic criteria consist of biochemical parameters (liver function tests, immunoglobulins, autoantibodies), imaging (ultrasound, MRCP, ERCP) and histopathologic characteristics. The treatment of choice in AIH is a combined immunosuppressive therapy of prednisolone and azathioprine. Ursodeoxycholic acid is the treatment of choice for PBC and improves liver biochemistry and prolongs transplant-free survival by slowing histological progression in the majority of patients. To date, there is no effective medical treatment option for patients with PSC.",
keywords = "Autoimmune Diseases, Diagnosis, Differential, Humans, Liver Diseases, English Abstract, Journal Article",
author = "N Pannicke and C Schramm and Lohse, {A W}",
year = "2012",
month = aug,
doi = "10.1007/s00108-012-3096-4",
language = "Deutsch",
volume = "53",
pages = "943--54; quiz 955--6",
journal = "INTERNIST",
issn = "0020-9554",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Autoimmunerkrankungen der Leber

AU - Pannicke, N

AU - Schramm, C

AU - Lohse, A W

PY - 2012/8

Y1 - 2012/8

N2 - Autoimmune liver diseases are divided into autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). They play an important role in the differential diagnosis of acute and chronic liver diseases. Diagnostic criteria consist of biochemical parameters (liver function tests, immunoglobulins, autoantibodies), imaging (ultrasound, MRCP, ERCP) and histopathologic characteristics. The treatment of choice in AIH is a combined immunosuppressive therapy of prednisolone and azathioprine. Ursodeoxycholic acid is the treatment of choice for PBC and improves liver biochemistry and prolongs transplant-free survival by slowing histological progression in the majority of patients. To date, there is no effective medical treatment option for patients with PSC.

AB - Autoimmune liver diseases are divided into autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). They play an important role in the differential diagnosis of acute and chronic liver diseases. Diagnostic criteria consist of biochemical parameters (liver function tests, immunoglobulins, autoantibodies), imaging (ultrasound, MRCP, ERCP) and histopathologic characteristics. The treatment of choice in AIH is a combined immunosuppressive therapy of prednisolone and azathioprine. Ursodeoxycholic acid is the treatment of choice for PBC and improves liver biochemistry and prolongs transplant-free survival by slowing histological progression in the majority of patients. To date, there is no effective medical treatment option for patients with PSC.

KW - Autoimmune Diseases

KW - Diagnosis, Differential

KW - Humans

KW - Liver Diseases

KW - English Abstract

KW - Journal Article

U2 - 10.1007/s00108-012-3096-4

DO - 10.1007/s00108-012-3096-4

M3 - SCORING: Zeitschriftenaufsatz

C2 - 22806149

VL - 53

SP - 943-54; quiz 955-6

JO - INTERNIST

JF - INTERNIST

SN - 0020-9554

IS - 8

ER -