Research ExplorerPublicationsAutoimmunerkrankungen der Leber

Autoimmunerkrankungen der Leber

Standard

Autoimmunerkrankungen der Leber. / Lüth, S; Weiler-Normann, C; Schramm, C; Lohse, A W.

In: INTERNIST, Vol. 50, No. 3, 03.2009, p. 310-7.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Lüth, S, Weiler-Normann, C, Schramm, C & Lohse, AW 2009, 'Autoimmunerkrankungen der Leber', INTERNIST, vol. 50, no. 3, pp. 310-7. https://doi.org/10.1007/s00108-008-2254-1

APA

Lüth, S., Weiler-Normann, C., Schramm, C., & Lohse, A. W. (2009). Autoimmunerkrankungen der Leber. INTERNIST, 50(3), 310-7. https://doi.org/10.1007/s00108-008-2254-1

Vancouver

Lüth S, Weiler-Normann C, Schramm C, Lohse AW. Autoimmunerkrankungen der Leber. INTERNIST. 2009 Mar;50(3):310-7. https://doi.org/10.1007/s00108-008-2254-1

Bibtex

@article{4e0423e12cf44e03803a9cb5db410d96,
title = "Autoimmunerkrankungen der Leber",
abstract = "Autoimmune hepatitis (AIH) can occur in all age groups. AIH affects women more commonly than men (3:1). Clinical presentation may be an acute hepatitis up to fulminant liver failure, but can also be asymptomatic. AIH is characterized by lymphoplasmacellular infiltrates on liver biopsy, elevated liver enzymes in serum and the absence of active viral markers. Patients characteristically present with hypergammaglobulinemia, elevated serum levels of IgG and autoantibodies. Corticosteroids are the drug of choice for induction of remission, azathioprine the drug of choice for maintenance of remission. Rapid response to immunosuppressive treatment supports the diagnosis and leads to a good long-term prognosis.Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are immune mediated diseases affecting bile ducts. While PBC has a slow progression to cirrhosis and complications mostly will be limited to complications of cirrhosis, PSC additionally carries a high risk of developing cholangiocellular carcinoma. The treatment of choice in PBC and PSC is oral ursodeoxycholic acid which may slow progression of liver disease and may ameliorate lab findings.",
keywords = "Cholagogues and Choleretics, Hepatitis, Autoimmune, Humans, Ursodeoxycholic Acid, English Abstract, Journal Article, Review",
author = "S L{\"u}th and C Weiler-Normann and C Schramm and Lohse, {A W}",
year = "2009",
month = mar,
doi = "10.1007/s00108-008-2254-1",
language = "Deutsch",
volume = "50",
pages = "310--7",
journal = "INTERNIST",
issn = "0020-9554",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Autoimmunerkrankungen der Leber

AU - Lüth, S

AU - Weiler-Normann, C

AU - Schramm, C

AU - Lohse, A W

PY - 2009/3

Y1 - 2009/3

N2 - Autoimmune hepatitis (AIH) can occur in all age groups. AIH affects women more commonly than men (3:1). Clinical presentation may be an acute hepatitis up to fulminant liver failure, but can also be asymptomatic. AIH is characterized by lymphoplasmacellular infiltrates on liver biopsy, elevated liver enzymes in serum and the absence of active viral markers. Patients characteristically present with hypergammaglobulinemia, elevated serum levels of IgG and autoantibodies. Corticosteroids are the drug of choice for induction of remission, azathioprine the drug of choice for maintenance of remission. Rapid response to immunosuppressive treatment supports the diagnosis and leads to a good long-term prognosis.Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are immune mediated diseases affecting bile ducts. While PBC has a slow progression to cirrhosis and complications mostly will be limited to complications of cirrhosis, PSC additionally carries a high risk of developing cholangiocellular carcinoma. The treatment of choice in PBC and PSC is oral ursodeoxycholic acid which may slow progression of liver disease and may ameliorate lab findings.

AB - Autoimmune hepatitis (AIH) can occur in all age groups. AIH affects women more commonly than men (3:1). Clinical presentation may be an acute hepatitis up to fulminant liver failure, but can also be asymptomatic. AIH is characterized by lymphoplasmacellular infiltrates on liver biopsy, elevated liver enzymes in serum and the absence of active viral markers. Patients characteristically present with hypergammaglobulinemia, elevated serum levels of IgG and autoantibodies. Corticosteroids are the drug of choice for induction of remission, azathioprine the drug of choice for maintenance of remission. Rapid response to immunosuppressive treatment supports the diagnosis and leads to a good long-term prognosis.Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are immune mediated diseases affecting bile ducts. While PBC has a slow progression to cirrhosis and complications mostly will be limited to complications of cirrhosis, PSC additionally carries a high risk of developing cholangiocellular carcinoma. The treatment of choice in PBC and PSC is oral ursodeoxycholic acid which may slow progression of liver disease and may ameliorate lab findings.

KW - Cholagogues and Choleretics

KW - Hepatitis, Autoimmune

KW - Humans

KW - Ursodeoxycholic Acid

KW - English Abstract

KW - Journal Article

KW - Review

U2 - 10.1007/s00108-008-2254-1

DO - 10.1007/s00108-008-2254-1

M3 - SCORING: Review

C2 - 19225747

VL - 50

SP - 310

EP - 317

JO - INTERNIST

JF - INTERNIST

SN - 0020-9554

IS - 3

ER -