"Autoimmune(-Like)" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis: New Insights into Molecular Pathogenesis

Marcial Sebode; Lisa Schulz; Ansgar W Lohse

doi:10.3390/ijms18091954

"Autoimmune(-Like)" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis

Standard

"Autoimmune(-Like)" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis : New Insights into Molecular Pathogenesis. / Sebode, Marcial; Schulz, Lisa; Lohse, Ansgar W.

In: INT J MOL SCI, Vol. 18, No. 9, 12.09.2017, p. E1954.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Sebode, M, Schulz, L & Lohse, AW 2017, '"Autoimmune(-Like)" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis: New Insights into Molecular Pathogenesis', INT J MOL SCI, vol. 18, no. 9, pp. E1954. https://doi.org/10.3390/ijms18091954

APA

Sebode, M., Schulz, L., & Lohse, A. W. (2017). "Autoimmune(-Like)" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis: New Insights into Molecular Pathogenesis. INT J MOL SCI, 18(9), E1954. https://doi.org/10.3390/ijms18091954

Vancouver

Sebode M, Schulz L, Lohse AW. "Autoimmune(-Like)" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis: New Insights into Molecular Pathogenesis. INT J MOL SCI. 2017 Sep 12;18(9):E1954. https://doi.org/10.3390/ijms18091954

Bibtex

@article{6c4ec1ebf9b24d92a16de808f1701ada,

title = "{"}Autoimmune(-Like){"} Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis: New Insights into Molecular Pathogenesis",

abstract = "Idiosyncratic drug-induced liver injury (DILI) and hepatic injury due to herbal and dietary supplements (HDS) can adapt clinical characteristics of autoimmune hepatitis (AIH), such as the appearance of autoantibodies and infiltration of the liver by immune competent cells. To describe these cases of DILI/HDS, the poorly-defined term {"}autoimmune(-like){"} DILI/HDS came up. It is uncertain if these cases represent a subgroup of DILI/HDS with distinct pathomechanistic and prognostic features different from {"}classical{"} DILI/HDS. Besides, due to the overlap of clinical characteristics of {"}immune-mediated{"} DILI/HDS and AIH, both entities are not easy to differentiate. However, the demarcation is important, especially with regard to treatment: AIH requires long-term, mostly lifelong immunosuppression, whereas DILI/HDS does not. Only through exact diagnostic evaluation, exclusion of differential diagnoses and prolonged follow-up can the correct diagnosis reliably be made. Molecular mechanisms have not been analysed for the subgroup of {"}autoimmune(-like){"} DILI/HDS yet. However, several pathogenetic checkpoints of DILI/HDS in general and AIH are shared. An analysis of these shared mechanisms might hint at relevant molecular processes of {"}autoimmune(-like){"} DILI/HDS.",

keywords = "Journal Article, Review",

author = "Marcial Sebode and Lisa Schulz and Lohse, {Ansgar W}",

year = "2017",

month = sep,

day = "12",

doi = "10.3390/ijms18091954",

language = "English",

volume = "18",

pages = "E1954",

journal = "INT J MOL SCI",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "9",

}

RIS

TY - JOUR

T1 - "Autoimmune(-Like)" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis

T2 - New Insights into Molecular Pathogenesis

AU - Sebode, Marcial

AU - Schulz, Lisa

AU - Lohse, Ansgar W

PY - 2017/9/12

Y1 - 2017/9/12

N2 - Idiosyncratic drug-induced liver injury (DILI) and hepatic injury due to herbal and dietary supplements (HDS) can adapt clinical characteristics of autoimmune hepatitis (AIH), such as the appearance of autoantibodies and infiltration of the liver by immune competent cells. To describe these cases of DILI/HDS, the poorly-defined term "autoimmune(-like)" DILI/HDS came up. It is uncertain if these cases represent a subgroup of DILI/HDS with distinct pathomechanistic and prognostic features different from "classical" DILI/HDS. Besides, due to the overlap of clinical characteristics of "immune-mediated" DILI/HDS and AIH, both entities are not easy to differentiate. However, the demarcation is important, especially with regard to treatment: AIH requires long-term, mostly lifelong immunosuppression, whereas DILI/HDS does not. Only through exact diagnostic evaluation, exclusion of differential diagnoses and prolonged follow-up can the correct diagnosis reliably be made. Molecular mechanisms have not been analysed for the subgroup of "autoimmune(-like)" DILI/HDS yet. However, several pathogenetic checkpoints of DILI/HDS in general and AIH are shared. An analysis of these shared mechanisms might hint at relevant molecular processes of "autoimmune(-like)" DILI/HDS.

AB - Idiosyncratic drug-induced liver injury (DILI) and hepatic injury due to herbal and dietary supplements (HDS) can adapt clinical characteristics of autoimmune hepatitis (AIH), such as the appearance of autoantibodies and infiltration of the liver by immune competent cells. To describe these cases of DILI/HDS, the poorly-defined term "autoimmune(-like)" DILI/HDS came up. It is uncertain if these cases represent a subgroup of DILI/HDS with distinct pathomechanistic and prognostic features different from "classical" DILI/HDS. Besides, due to the overlap of clinical characteristics of "immune-mediated" DILI/HDS and AIH, both entities are not easy to differentiate. However, the demarcation is important, especially with regard to treatment: AIH requires long-term, mostly lifelong immunosuppression, whereas DILI/HDS does not. Only through exact diagnostic evaluation, exclusion of differential diagnoses and prolonged follow-up can the correct diagnosis reliably be made. Molecular mechanisms have not been analysed for the subgroup of "autoimmune(-like)" DILI/HDS yet. However, several pathogenetic checkpoints of DILI/HDS in general and AIH are shared. An analysis of these shared mechanisms might hint at relevant molecular processes of "autoimmune(-like)" DILI/HDS.

KW - Journal Article

KW - Review

U2 - 10.3390/ijms18091954

DO - 10.3390/ijms18091954

M3 - SCORING: Review article

C2 - 28895915

VL - 18

SP - E1954

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 9

ER -