[Autoimmune synaptic encephalopathies].
Standard
[Autoimmune synaptic encephalopathies]. / Friese, Manuel A.; Magnus, Tim.
In: NERVENARZT, Vol. 82, No. 10, 10, 2011, p. 1239-1249.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - [Autoimmune synaptic encephalopathies].
AU - Friese, Manuel A.
AU - Magnus, Tim
PY - 2011
Y1 - 2011
N2 - Antibody-associated limbic encephalitis was usually seen as a paraneoplastic syndrome where the antibodies would target intracellular proteins. However, recent reports challenged this idea and described antibodies that target synaptic proteins expressed on the cell surface. These antibodies are not necessarily linked to tumors and should be regarded as a distinct entity of different autoimmune diseases. They are of direct clinical relevance since their binding to their target antigen is likely the cause of the clinical symptoms and, therefore, immune treatment often results in a beneficial outcome. Tests which differentiate these antibodies are now available in specialized laboratories.
AB - Antibody-associated limbic encephalitis was usually seen as a paraneoplastic syndrome where the antibodies would target intracellular proteins. However, recent reports challenged this idea and described antibodies that target synaptic proteins expressed on the cell surface. These antibodies are not necessarily linked to tumors and should be regarded as a distinct entity of different autoimmune diseases. They are of direct clinical relevance since their binding to their target antigen is likely the cause of the clinical symptoms and, therefore, immune treatment often results in a beneficial outcome. Tests which differentiate these antibodies are now available in specialized laboratories.
M3 - SCORING: Zeitschriftenaufsatz
VL - 82
SP - 1239
EP - 1249
JO - NERVENARZT
JF - NERVENARZT
SN - 0028-2804
IS - 10
M1 - 10
ER -
