Autoimmune modulation of astrocyte-mediated homeostasis.
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Autoimmune modulation of astrocyte-mediated homeostasis. / Korn, Thomas; Rao, Mahendra; Magnus, Tim.
In: NEUROMOL MED, Vol. 9, No. 1, 1, 2007, p. 1-16.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Autoimmune modulation of astrocyte-mediated homeostasis.
AU - Korn, Thomas
AU - Rao, Mahendra
AU - Magnus, Tim
PY - 2007
Y1 - 2007
N2 - Astrocytes are principal mediators of homeostasis in the central nervous system (CNS). They supply neurons and oligodendrocytes with substrates for energy metabolism and clear the extracellular space of excess neurotransmitters. In neuroinflammation, astrocytes have classically been regarded as unimportant since their capacity to present antigen to T cells is limited and has been questioned in vivo. However, it is an evolving concept that autoimmunity in the CNS has a profound impact on astrocytes. In this review, we focus on the alterations in astrocyte functions that occur during an autoimmune attack of the CNS.
AB - Astrocytes are principal mediators of homeostasis in the central nervous system (CNS). They supply neurons and oligodendrocytes with substrates for energy metabolism and clear the extracellular space of excess neurotransmitters. In neuroinflammation, astrocytes have classically been regarded as unimportant since their capacity to present antigen to T cells is limited and has been questioned in vivo. However, it is an evolving concept that autoimmunity in the CNS has a profound impact on astrocytes. In this review, we focus on the alterations in astrocyte functions that occur during an autoimmune attack of the CNS.
M3 - SCORING: Zeitschriftenaufsatz
VL - 9
SP - 1
EP - 16
JO - NEUROMOL MED
JF - NEUROMOL MED
SN - 1535-1084
IS - 1
M1 - 1
ER -
