Autoantibody-associated psychiatric syndromes in children: link to adult psychiatry
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Autoantibody-associated psychiatric syndromes in children: link to adult psychiatry. / Hansen, Niels; Luedecke, Daniel; Malchow, Berend; Lipp, Michael; Vogelgsang, Jonathan; Timäus, Charles; Zindler, Tristan; Gingele, Stefan; Kühn, Simone; Gallinat, Jürgen; Wiedemann, Klaus; Denk, Johannes; Moschny, Nicole; Fiehler, Jens; Skripuletz, Thomas; Riedel, Christian; Wattjes, Mike P; Zerr, Inga; Esselmann, Hermann; Poustka, Luise; Karow, Anne; Hartmann, Hans; Frieling, Helge; Bleich, Stefan; Wiltfang, Jens; Neyazi, Alexandra; CAP (Cerebrospinal Fluid Analysis in Psychiatry) Consortium.
In: J NEURAL TRANSM, Vol. 128, No. 6, 06.2021, p. 735-747.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Autoantibody-associated psychiatric syndromes in children: link to adult psychiatry
AU - Hansen, Niels
AU - Luedecke, Daniel
AU - Malchow, Berend
AU - Lipp, Michael
AU - Vogelgsang, Jonathan
AU - Timäus, Charles
AU - Zindler, Tristan
AU - Gingele, Stefan
AU - Kühn, Simone
AU - Gallinat, Jürgen
AU - Wiedemann, Klaus
AU - Denk, Johannes
AU - Moschny, Nicole
AU - Fiehler, Jens
AU - Skripuletz, Thomas
AU - Riedel, Christian
AU - Wattjes, Mike P
AU - Zerr, Inga
AU - Esselmann, Hermann
AU - Poustka, Luise
AU - Karow, Anne
AU - Hartmann, Hans
AU - Frieling, Helge
AU - Bleich, Stefan
AU - Wiltfang, Jens
AU - Neyazi, Alexandra
AU - CAP (Cerebrospinal Fluid Analysis in Psychiatry) Consortium
PY - 2021/6
Y1 - 2021/6
N2 - Studies show that psychiatric symptoms in adults and children are sometimes associated with serum neural autoantibodies. The significance of serum neural autoantibodies associated with psychiatric symptoms in children remains often unclear, but might be relevant for the extent and occurrence of psychiatric disease manifestation in later life, as well as therapy and outcome. For this narrative review, we sought articles listed in PubMed and published between 1988 and 2020 addressing the maternal-fetal transfer of neural autoantibodies and psychiatric disorders associated with serum neural autoantibodies. We identified six major subgroups of psychiatric disorders in children that are associated with serum neural autoantibodies: patients with attentional deficit hyperactivity disorder, autism spectrum disorder, obsessive compulsive disorder, Gilles de la Tourette syndrome, psychosis and catatonia. Furthermore, we summarized study findings from maternal-fetal transfer of Contactin-associated protein-like 2, N-methyl-D-aspartate receptor and fetal brain autoantibodies associated with behavioral effects in animals and humans. We hypothesize that the maternal transfer of serum neuronal autoantibodies during or after birth could result (1) in the ignition of an autoimmune-mediated inflammation having neurodevelopmental consequences for their children (autoimmune-priming-attack hypothesis) and (2) has a potential impact on the later manifestation of psychiatric disorders. Through this narrative review, we propose a diagnostic pathway for the clinical diagnosis of a potentially autoimmune origin of psychiatric symptoms in children while considering recent guidelines.
AB - Studies show that psychiatric symptoms in adults and children are sometimes associated with serum neural autoantibodies. The significance of serum neural autoantibodies associated with psychiatric symptoms in children remains often unclear, but might be relevant for the extent and occurrence of psychiatric disease manifestation in later life, as well as therapy and outcome. For this narrative review, we sought articles listed in PubMed and published between 1988 and 2020 addressing the maternal-fetal transfer of neural autoantibodies and psychiatric disorders associated with serum neural autoantibodies. We identified six major subgroups of psychiatric disorders in children that are associated with serum neural autoantibodies: patients with attentional deficit hyperactivity disorder, autism spectrum disorder, obsessive compulsive disorder, Gilles de la Tourette syndrome, psychosis and catatonia. Furthermore, we summarized study findings from maternal-fetal transfer of Contactin-associated protein-like 2, N-methyl-D-aspartate receptor and fetal brain autoantibodies associated with behavioral effects in animals and humans. We hypothesize that the maternal transfer of serum neuronal autoantibodies during or after birth could result (1) in the ignition of an autoimmune-mediated inflammation having neurodevelopmental consequences for their children (autoimmune-priming-attack hypothesis) and (2) has a potential impact on the later manifestation of psychiatric disorders. Through this narrative review, we propose a diagnostic pathway for the clinical diagnosis of a potentially autoimmune origin of psychiatric symptoms in children while considering recent guidelines.
KW - Adult
KW - Animals
KW - Autism Spectrum Disorder
KW - Autoantibodies
KW - Child
KW - Humans
KW - Obsessive-Compulsive Disorder
KW - Psychiatry
KW - Psychotic Disorders
U2 - 10.1007/s00702-021-02354-8
DO - 10.1007/s00702-021-02354-8
M3 - SCORING: Review article
C2 - 34057596
VL - 128
SP - 735
EP - 747
JO - J NEURAL TRANSM
JF - J NEURAL TRANSM
SN - 0300-9564
IS - 6
ER -
