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Autoantibodies to intracellular "rods and rings" structures in two patients with autoimmune hepatitis treated with azathioprine

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Autoantibodies to intracellular "rods and rings" structures in two patients with autoimmune hepatitis treated with azathioprine. / Galaski, Johanna; Koop, Anja C; Lütgehetmann, Marc; Lohse, Ansgar W; Weiler-Normann, Christina.

In: AUTOIMMUNITY, Vol. 53, No. 6, 09.2020, p. 362-365.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Galaski, J, Koop, AC, Lütgehetmann, M, Lohse, AW & Weiler-Normann, C 2020, 'Autoantibodies to intracellular "rods and rings" structures in two patients with autoimmune hepatitis treated with azathioprine', AUTOIMMUNITY, vol. 53, no. 6, pp. 362-365. https://doi.org/10.1080/08916934.2020.1793135

APA

Galaski, J., Koop, A. C., Lütgehetmann, M., Lohse, A. W., & Weiler-Normann, C. (2020). Autoantibodies to intracellular "rods and rings" structures in two patients with autoimmune hepatitis treated with azathioprine. AUTOIMMUNITY, 53(6), 362-365. https://doi.org/10.1080/08916934.2020.1793135

Vancouver

Galaski J, Koop AC, Lütgehetmann M, Lohse AW, Weiler-Normann C. Autoantibodies to intracellular "rods and rings" structures in two patients with autoimmune hepatitis treated with azathioprine. AUTOIMMUNITY. 2020 Sep;53(6):362-365. https://doi.org/10.1080/08916934.2020.1793135

Bibtex

@article{01ed248b45204f8d809d70acb864881d,
title = "Autoantibodies to intracellular {"}rods and rings{"} structures in two patients with autoimmune hepatitis treated with azathioprine",
abstract = "In vitro, inhibition of the synthesis of guanosine monophosphate (GMP) by various drugs such as ribavirin, acyclovir, azathioprine, and mycophenolic acid leads to the formation of subcellular structures in cultured cells. Autoantibodies targeting these cellular structures can be detected as {"}rods and rings{"} (RR) patterns by immunofluorescence. In vivo, autoantibodies to RR have been almost exclusively associated with hepatitis C virus patients treated with pegylated interferon-α and ribavirin. However, longitudinal data for other patient groups are scarce. Here, we reviewed 276 sequential immunofluorescence results from 127 patients with autoimmune hepatitis for the presence of RR patterns. Of 102 patients exposed to drugs known to induce RR in vitro, two patients under long-term azathioprine therapy were positive for this pattern. This is the first report of anti-RR in patients with autoimmune hepatitis and in patients treated with azathioprine.",
author = "Johanna Galaski and Koop, {Anja C} and Marc L{\"u}tgehetmann and Lohse, {Ansgar W} and Christina Weiler-Normann",
year = "2020",
month = sep,
doi = "10.1080/08916934.2020.1793135",
language = "English",
volume = "53",
pages = "362--365",
journal = "AUTOIMMUNITY",
issn = "0891-6934",
publisher = "informa healthcare",
number = "6",

}

RIS

TY - JOUR

T1 - Autoantibodies to intracellular "rods and rings" structures in two patients with autoimmune hepatitis treated with azathioprine

AU - Galaski, Johanna

AU - Koop, Anja C

AU - Lütgehetmann, Marc

AU - Lohse, Ansgar W

AU - Weiler-Normann, Christina

PY - 2020/9

Y1 - 2020/9

N2 - In vitro, inhibition of the synthesis of guanosine monophosphate (GMP) by various drugs such as ribavirin, acyclovir, azathioprine, and mycophenolic acid leads to the formation of subcellular structures in cultured cells. Autoantibodies targeting these cellular structures can be detected as "rods and rings" (RR) patterns by immunofluorescence. In vivo, autoantibodies to RR have been almost exclusively associated with hepatitis C virus patients treated with pegylated interferon-α and ribavirin. However, longitudinal data for other patient groups are scarce. Here, we reviewed 276 sequential immunofluorescence results from 127 patients with autoimmune hepatitis for the presence of RR patterns. Of 102 patients exposed to drugs known to induce RR in vitro, two patients under long-term azathioprine therapy were positive for this pattern. This is the first report of anti-RR in patients with autoimmune hepatitis and in patients treated with azathioprine.

AB - In vitro, inhibition of the synthesis of guanosine monophosphate (GMP) by various drugs such as ribavirin, acyclovir, azathioprine, and mycophenolic acid leads to the formation of subcellular structures in cultured cells. Autoantibodies targeting these cellular structures can be detected as "rods and rings" (RR) patterns by immunofluorescence. In vivo, autoantibodies to RR have been almost exclusively associated with hepatitis C virus patients treated with pegylated interferon-α and ribavirin. However, longitudinal data for other patient groups are scarce. Here, we reviewed 276 sequential immunofluorescence results from 127 patients with autoimmune hepatitis for the presence of RR patterns. Of 102 patients exposed to drugs known to induce RR in vitro, two patients under long-term azathioprine therapy were positive for this pattern. This is the first report of anti-RR in patients with autoimmune hepatitis and in patients treated with azathioprine.

U2 - 10.1080/08916934.2020.1793135

DO - 10.1080/08916934.2020.1793135

M3 - SCORING: Journal article

C2 - 32662301

VL - 53

SP - 362

EP - 365

JO - AUTOIMMUNITY

JF - AUTOIMMUNITY

SN - 0891-6934

IS - 6

ER -