Research ExplorerPublicationsAutoantibodies against beta-amyloid are common in Alzheimer'...

Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden.

Standard

Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden. / Kellner, Alexander; Matschke, Jakob; Bernreuther, Christian; Moch, Holger; Ferrer, Isidro; Glatzel, Markus.

In: ANN NEUROL, Vol. 65, No. 1, 1, 2009, p. 24-31.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kellner, A, Matschke, J, Bernreuther, C, Moch, H, Ferrer, I & Glatzel, M 2009, 'Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden.', ANN NEUROL, vol. 65, no. 1, 1, pp. 24-31. <http://www.ncbi.nlm.nih.gov/pubmed/19194878?dopt=Citation>

APA

Kellner, A., Matschke, J., Bernreuther, C., Moch, H., Ferrer, I., & Glatzel, M. (2009). Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden. ANN NEUROL, 65(1), 24-31. [1]. http://www.ncbi.nlm.nih.gov/pubmed/19194878?dopt=Citation

Vancouver

Kellner A, Matschke J, Bernreuther C, Moch H, Ferrer I, Glatzel M. Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden. ANN NEUROL. 2009;65(1):24-31. 1.

Bibtex

@article{2667d04482f5482697ca04a4b08dd435,
title = "Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden.",
abstract = "OBJECTIVE: Active or passive immunization of Alzheimer's disease (AD) patients leads to targeting of beta-amyloid plaques by immunoglobulins (IgG) and their subsequent removal by microglia. Here, we investigate whether naturally occurring autoantibodies to beta-amyloid contribute to beta-amyloid plaque removal in nonimmunized AD patients. METHODS: We generated an AD tissue microarray with 2,325 tissue specimens from 3 defined central nervous system regions of 48 AD patients and 48 age-matched control patients. Absolute quantification of beta-amyloid, beta-amyloid plaque-bound IgG, and phagocytic, resting, and activated microglia and microhemorrhages was done using a standardized, highly reproducible scoring system. RESULTS: The majority of neuritic plaques are decorated by IgG. AD patients with prominently IgG-labeled neuritic plaques have a significantly reduced plaque burden and an increase in phagocytic microglia, yet no increase in microhemorrhages. INTERPRETATION: Autoantibodies directed against beta-amyloid are common in AD patients and may contribute in controlling plaque burden.",
author = "Alexander Kellner and Jakob Matschke and Christian Bernreuther and Holger Moch and Isidro Ferrer and Markus Glatzel",
year = "2009",
language = "Deutsch",
volume = "65",
pages = "24--31",
journal = "ANN NEUROL",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Autoantibodies against beta-amyloid are common in Alzheimer's disease and help control plaque burden.

AU - Kellner, Alexander

AU - Matschke, Jakob

AU - Bernreuther, Christian

AU - Moch, Holger

AU - Ferrer, Isidro

AU - Glatzel, Markus

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: Active or passive immunization of Alzheimer's disease (AD) patients leads to targeting of beta-amyloid plaques by immunoglobulins (IgG) and their subsequent removal by microglia. Here, we investigate whether naturally occurring autoantibodies to beta-amyloid contribute to beta-amyloid plaque removal in nonimmunized AD patients. METHODS: We generated an AD tissue microarray with 2,325 tissue specimens from 3 defined central nervous system regions of 48 AD patients and 48 age-matched control patients. Absolute quantification of beta-amyloid, beta-amyloid plaque-bound IgG, and phagocytic, resting, and activated microglia and microhemorrhages was done using a standardized, highly reproducible scoring system. RESULTS: The majority of neuritic plaques are decorated by IgG. AD patients with prominently IgG-labeled neuritic plaques have a significantly reduced plaque burden and an increase in phagocytic microglia, yet no increase in microhemorrhages. INTERPRETATION: Autoantibodies directed against beta-amyloid are common in AD patients and may contribute in controlling plaque burden.

AB - OBJECTIVE: Active or passive immunization of Alzheimer's disease (AD) patients leads to targeting of beta-amyloid plaques by immunoglobulins (IgG) and their subsequent removal by microglia. Here, we investigate whether naturally occurring autoantibodies to beta-amyloid contribute to beta-amyloid plaque removal in nonimmunized AD patients. METHODS: We generated an AD tissue microarray with 2,325 tissue specimens from 3 defined central nervous system regions of 48 AD patients and 48 age-matched control patients. Absolute quantification of beta-amyloid, beta-amyloid plaque-bound IgG, and phagocytic, resting, and activated microglia and microhemorrhages was done using a standardized, highly reproducible scoring system. RESULTS: The majority of neuritic plaques are decorated by IgG. AD patients with prominently IgG-labeled neuritic plaques have a significantly reduced plaque burden and an increase in phagocytic microglia, yet no increase in microhemorrhages. INTERPRETATION: Autoantibodies directed against beta-amyloid are common in AD patients and may contribute in controlling plaque burden.

M3 - SCORING: Zeitschriftenaufsatz

VL - 65

SP - 24

EP - 31

JO - ANN NEUROL

JF - ANN NEUROL

SN - 0364-5134

IS - 1

M1 - 1

ER -