Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors.
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Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors. / Mutschler, Jochen; Bilbao, Ainhoa; von der Goltz, Christoph; Demiralay, Cüneyt; Jahn, Holger; Wiedemann, Klaus; Spanagel, Rainer; Kiefer, Falk.
In: ALCOHOL ALCOHOLISM, Vol. 45, No. 1, 1, 2010, p. 13-16.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors.
AU - Mutschler, Jochen
AU - Bilbao, Ainhoa
AU - von der Goltz, Christoph
AU - Demiralay, Cüneyt
AU - Jahn, Holger
AU - Wiedemann, Klaus
AU - Spanagel, Rainer
AU - Kiefer, Falk
PY - 2010
Y1 - 2010
N2 - AIMS: Preclinical and clinical data suggest an involvement of atrial natriuretic peptides (ANP) in alcohol-associated psychopathology. We now present first data on alcohol drinking behaviour in mice lacking a functional natriuretic peptide-A (NPR-A) receptor. METHODS: NPR-A(-/-) and wild-type mice were given a free choice between water and increasing concentrations of alcohol (2-16%). A forced swim stress was performed thereafter on three consecutive days to investigate stress-induced alcohol drinking. Additionally, neurobehavioural alcohol withdrawal response was investigated following 14 days of forced-alcohol intake. RESULTS: Whereas basal alcohol intake did not differ between NPR-A mutants and wild-type littermates, NPR-A mutants showed an increased stress-induced alcohol intake and aggravated neurobehavioural symptoms of alcohol withdrawal. CONCLUSIONS: Mice lacking a functional NPR-A receptor represent a useful model to study the role of the ANP system in alcohol-associated pathology. To study the role of the natriuretic NPR-A gene for the modulation of risk of alcohol-related disorders, NPR-A-related polymorphisms should be targeted in clinical studies.
AB - AIMS: Preclinical and clinical data suggest an involvement of atrial natriuretic peptides (ANP) in alcohol-associated psychopathology. We now present first data on alcohol drinking behaviour in mice lacking a functional natriuretic peptide-A (NPR-A) receptor. METHODS: NPR-A(-/-) and wild-type mice were given a free choice between water and increasing concentrations of alcohol (2-16%). A forced swim stress was performed thereafter on three consecutive days to investigate stress-induced alcohol drinking. Additionally, neurobehavioural alcohol withdrawal response was investigated following 14 days of forced-alcohol intake. RESULTS: Whereas basal alcohol intake did not differ between NPR-A mutants and wild-type littermates, NPR-A mutants showed an increased stress-induced alcohol intake and aggravated neurobehavioural symptoms of alcohol withdrawal. CONCLUSIONS: Mice lacking a functional NPR-A receptor represent a useful model to study the role of the ANP system in alcohol-associated pathology. To study the role of the natriuretic NPR-A gene for the modulation of risk of alcohol-related disorders, NPR-A-related polymorphisms should be targeted in clinical studies.
M3 - SCORING: Zeitschriftenaufsatz
VL - 45
SP - 13
EP - 16
JO - ALCOHOL ALCOHOLISM
JF - ALCOHOL ALCOHOLISM
SN - 0735-0414
IS - 1
M1 - 1
ER -
