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Augmentation index relates to progression of aortic disease in adults with Marfan syndrome

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Augmentation index relates to progression of aortic disease in adults with Marfan syndrome. / Mortensen, Kai; Aydin, Muhammet A; Rybczynski, Meike; Baulmann, Johannes; Schahidi, Nazila Abdul; Kean, Georgina; Kühne, Kristine; Bernhardt, Alexander M J; Franzen, Olaf; Mir, Thomas; Habermann, Christian; Koschyk, Dietmar; Ventura, Rodolfo; Willems, Stephan; Robinson, Peter N; Berger, Jürgen; Reichenspurner, Hermann; Meinertz, Thomas; von Kodolitsch, Yskert.

In: AM J HYPERTENS, Vol. 22, No. 9, 09.2009, p. 971-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mortensen, K, Aydin, MA, Rybczynski, M, Baulmann, J, Schahidi, NA, Kean, G, Kühne, K, Bernhardt, AMJ, Franzen, O, Mir, T, Habermann, C, Koschyk, D, Ventura, R, Willems, S, Robinson, PN, Berger, J, Reichenspurner, H, Meinertz, T & von Kodolitsch, Y 2009, 'Augmentation index relates to progression of aortic disease in adults with Marfan syndrome', AM J HYPERTENS, vol. 22, no. 9, pp. 971-9. https://doi.org/10.1038/ajh.2009.115

APA

Mortensen, K., Aydin, M. A., Rybczynski, M., Baulmann, J., Schahidi, N. A., Kean, G., Kühne, K., Bernhardt, A. M. J., Franzen, O., Mir, T., Habermann, C., Koschyk, D., Ventura, R., Willems, S., Robinson, P. N., Berger, J., Reichenspurner, H., Meinertz, T., & von Kodolitsch, Y. (2009). Augmentation index relates to progression of aortic disease in adults with Marfan syndrome. AM J HYPERTENS, 22(9), 971-9. https://doi.org/10.1038/ajh.2009.115

Vancouver

Mortensen K, Aydin MA, Rybczynski M, Baulmann J, Schahidi NA, Kean G et al. Augmentation index relates to progression of aortic disease in adults with Marfan syndrome. AM J HYPERTENS. 2009 Sep;22(9):971-9. https://doi.org/10.1038/ajh.2009.115

Bibtex

@article{744779c76c49436d84901d3b3ab5b7d8,
title = "Augmentation index relates to progression of aortic disease in adults with Marfan syndrome",
abstract = "BACKGROUND: Noninvasive applanation tonometry (APT) is useful to assess aortic stiffness and pulse wave reflection. Moreover, APT can predict outcome in many conditions such as arterial hypertension. In this study, we test whether APT measurements relate to progression of aortic disease in Marfan syndrome (MFS).METHODS: We performed APT in 50 consecutive, medically treated adults with MFS (19 men and 31 women aged 32 +/- 13 years), who had not undergone previous cardiovascular surgery. During 22 +/- 16 months of follow-up, 26 of these patients developed progression of aortic disease, which we defined as progression of aortic root diameters >or=5 mm/annum (18 individuals), aortic surgery >or=3 months after APT (seven individuals), or onset of acute aortic dissection any time after APT (one individual).RESULTS: Univariate Cox regression analysis suggested an association of aortic disease progression with age (P = 0.001), total cholesterol levels (P = 0.04), aortic root diameter (P = 0.007), descending aorta diameter (P = 0.01), aortic root ratio (P = 0.02), and augmentation index (AIx@HR75; P < 0.006). Multivariate Cox regression analysis confirmed an independent impact on aortic disease progression exclusively for baseline aortic root diameters (hazard ratio = 1.347; 95% confidence interval (CI) 1.104-1.643; P = 0.003) and AIx@HR75 (hazard ratio = 1.246; 95% CI 1.029-1.508; P = 0.02). In addition, Kaplan-Meier survival curve analysis illustrated significantly lower rates of aortic root disease progression both with lower AIx@HR75 (P = 0.025) and with lower pulse wave velocity (PWV) values (P = 0.027).CONCLUSIONS: We provide evidence that APT parameters relate to aortic disease progression in medically treated patients with MFS. We believe that APT has a potential to improve risk stratification in the clinical management of MFS patients.",
keywords = "Adult, Aortic Diseases/physiopathology, Disease Progression, Elasticity, Female, Hemodynamics, Humans, Male, Manometry/methods, Marfan Syndrome/diagnosis, Regression Analysis",
author = "Kai Mortensen and Aydin, {Muhammet A} and Meike Rybczynski and Johannes Baulmann and Schahidi, {Nazila Abdul} and Georgina Kean and Kristine K{\"u}hne and Bernhardt, {Alexander M J} and Olaf Franzen and Thomas Mir and Christian Habermann and Dietmar Koschyk and Rodolfo Ventura and Stephan Willems and Robinson, {Peter N} and J{\"u}rgen Berger and Hermann Reichenspurner and Thomas Meinertz and {von Kodolitsch}, Yskert",
year = "2009",
month = sep,
doi = "10.1038/ajh.2009.115",
language = "English",
volume = "22",
pages = "971--9",
journal = "AM J HYPERTENS",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Augmentation index relates to progression of aortic disease in adults with Marfan syndrome

AU - Mortensen, Kai

AU - Aydin, Muhammet A

AU - Rybczynski, Meike

AU - Baulmann, Johannes

AU - Schahidi, Nazila Abdul

AU - Kean, Georgina

AU - Kühne, Kristine

AU - Bernhardt, Alexander M J

AU - Franzen, Olaf

AU - Mir, Thomas

AU - Habermann, Christian

AU - Koschyk, Dietmar

AU - Ventura, Rodolfo

AU - Willems, Stephan

AU - Robinson, Peter N

AU - Berger, Jürgen

AU - Reichenspurner, Hermann

AU - Meinertz, Thomas

AU - von Kodolitsch, Yskert

PY - 2009/9

Y1 - 2009/9

N2 - BACKGROUND: Noninvasive applanation tonometry (APT) is useful to assess aortic stiffness and pulse wave reflection. Moreover, APT can predict outcome in many conditions such as arterial hypertension. In this study, we test whether APT measurements relate to progression of aortic disease in Marfan syndrome (MFS).METHODS: We performed APT in 50 consecutive, medically treated adults with MFS (19 men and 31 women aged 32 +/- 13 years), who had not undergone previous cardiovascular surgery. During 22 +/- 16 months of follow-up, 26 of these patients developed progression of aortic disease, which we defined as progression of aortic root diameters >or=5 mm/annum (18 individuals), aortic surgery >or=3 months after APT (seven individuals), or onset of acute aortic dissection any time after APT (one individual).RESULTS: Univariate Cox regression analysis suggested an association of aortic disease progression with age (P = 0.001), total cholesterol levels (P = 0.04), aortic root diameter (P = 0.007), descending aorta diameter (P = 0.01), aortic root ratio (P = 0.02), and augmentation index (AIx@HR75; P < 0.006). Multivariate Cox regression analysis confirmed an independent impact on aortic disease progression exclusively for baseline aortic root diameters (hazard ratio = 1.347; 95% confidence interval (CI) 1.104-1.643; P = 0.003) and AIx@HR75 (hazard ratio = 1.246; 95% CI 1.029-1.508; P = 0.02). In addition, Kaplan-Meier survival curve analysis illustrated significantly lower rates of aortic root disease progression both with lower AIx@HR75 (P = 0.025) and with lower pulse wave velocity (PWV) values (P = 0.027).CONCLUSIONS: We provide evidence that APT parameters relate to aortic disease progression in medically treated patients with MFS. We believe that APT has a potential to improve risk stratification in the clinical management of MFS patients.

AB - BACKGROUND: Noninvasive applanation tonometry (APT) is useful to assess aortic stiffness and pulse wave reflection. Moreover, APT can predict outcome in many conditions such as arterial hypertension. In this study, we test whether APT measurements relate to progression of aortic disease in Marfan syndrome (MFS).METHODS: We performed APT in 50 consecutive, medically treated adults with MFS (19 men and 31 women aged 32 +/- 13 years), who had not undergone previous cardiovascular surgery. During 22 +/- 16 months of follow-up, 26 of these patients developed progression of aortic disease, which we defined as progression of aortic root diameters >or=5 mm/annum (18 individuals), aortic surgery >or=3 months after APT (seven individuals), or onset of acute aortic dissection any time after APT (one individual).RESULTS: Univariate Cox regression analysis suggested an association of aortic disease progression with age (P = 0.001), total cholesterol levels (P = 0.04), aortic root diameter (P = 0.007), descending aorta diameter (P = 0.01), aortic root ratio (P = 0.02), and augmentation index (AIx@HR75; P < 0.006). Multivariate Cox regression analysis confirmed an independent impact on aortic disease progression exclusively for baseline aortic root diameters (hazard ratio = 1.347; 95% confidence interval (CI) 1.104-1.643; P = 0.003) and AIx@HR75 (hazard ratio = 1.246; 95% CI 1.029-1.508; P = 0.02). In addition, Kaplan-Meier survival curve analysis illustrated significantly lower rates of aortic root disease progression both with lower AIx@HR75 (P = 0.025) and with lower pulse wave velocity (PWV) values (P = 0.027).CONCLUSIONS: We provide evidence that APT parameters relate to aortic disease progression in medically treated patients with MFS. We believe that APT has a potential to improve risk stratification in the clinical management of MFS patients.

KW - Adult

KW - Aortic Diseases/physiopathology

KW - Disease Progression

KW - Elasticity

KW - Female

KW - Hemodynamics

KW - Humans

KW - Male

KW - Manometry/methods

KW - Marfan Syndrome/diagnosis

KW - Regression Analysis

U2 - 10.1038/ajh.2009.115

DO - 10.1038/ajh.2009.115

M3 - SCORING: Journal article

C2 - 19574960

VL - 22

SP - 971

EP - 979

JO - AM J HYPERTENS

JF - AM J HYPERTENS

SN - 0895-7061

IS - 9

ER -