Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia
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Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia. / Wigand, Marlene; Kubicki, Marek; Clemm von Hohenberg, Christian; Leicht, Gregor; Karch, Susanne; Eckbo, Ryan; Pelavin, Paula E; Hawley, Kathryn; Rujescu, Dan; Bouix, Sylvain; Shenton, Martha E; Mulert, Christoph.
In: WORLD J BIOL PSYCHIA, Vol. 16, No. 1, 01.01.2015, p. 31-44.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Auditory verbal hallucinations and the interhemispheric auditory pathway in chronic schizophrenia
AU - Wigand, Marlene
AU - Kubicki, Marek
AU - Clemm von Hohenberg, Christian
AU - Leicht, Gregor
AU - Karch, Susanne
AU - Eckbo, Ryan
AU - Pelavin, Paula E
AU - Hawley, Kathryn
AU - Rujescu, Dan
AU - Bouix, Sylvain
AU - Shenton, Martha E
AU - Mulert, Christoph
PY - 2015/1/1
Y1 - 2015/1/1
N2 - OBJECTIVES: The interhemispheric auditory pathway has been shown to play a crucial role in the processing of acoustic stimuli, and alterations of structural and functional connectivity between bilateral auditory areas are likely relevant to the pathogenesis of auditory verbal hallucinations (AVHs). The aim of this study was to examine this pathway in patients with chronic schizophrenia regarding their lifetime history of AVHs.METHODS: DTI scans were acquired from 33 healthy controls (HC), 24 schizophrenia patients with a history of AVHs (LT-AVH) and nine schizophrenia patients without any lifetime hallucinations (N-LT-AVH). The interhemispheric auditory fibre bundles were extracted using streamline tractography. Subsequently, diffusivity indices, namely Fractional Anisotropy (FA), Trace, Mode, Axial and Radial diffusivity, were calculated.RESULTS: FA was decreased over the entire pathway in LT-AVH compared with N-LT-AVH. Moreover, LT-AVH displayed decreased FA and Mode as well as increased radial diffusivity in the midsagittal section of the fibre tract.CONCLUSIONS: These findings indicate complex microstructural changes in the interhemispheric auditory pathway of schizophrenia patients with a history of AVHs. Alterations appear to be absent in patients who have never hallucinated.
AB - OBJECTIVES: The interhemispheric auditory pathway has been shown to play a crucial role in the processing of acoustic stimuli, and alterations of structural and functional connectivity between bilateral auditory areas are likely relevant to the pathogenesis of auditory verbal hallucinations (AVHs). The aim of this study was to examine this pathway in patients with chronic schizophrenia regarding their lifetime history of AVHs.METHODS: DTI scans were acquired from 33 healthy controls (HC), 24 schizophrenia patients with a history of AVHs (LT-AVH) and nine schizophrenia patients without any lifetime hallucinations (N-LT-AVH). The interhemispheric auditory fibre bundles were extracted using streamline tractography. Subsequently, diffusivity indices, namely Fractional Anisotropy (FA), Trace, Mode, Axial and Radial diffusivity, were calculated.RESULTS: FA was decreased over the entire pathway in LT-AVH compared with N-LT-AVH. Moreover, LT-AVH displayed decreased FA and Mode as well as increased radial diffusivity in the midsagittal section of the fibre tract.CONCLUSIONS: These findings indicate complex microstructural changes in the interhemispheric auditory pathway of schizophrenia patients with a history of AVHs. Alterations appear to be absent in patients who have never hallucinated.
U2 - 10.3109/15622975.2014.948063
DO - 10.3109/15622975.2014.948063
M3 - SCORING: Journal article
C2 - 25224883
VL - 16
SP - 31
EP - 44
JO - WORLD J BIOL PSYCHIA
JF - WORLD J BIOL PSYCHIA
SN - 1562-2975
IS - 1
ER -
