Atypical teratoid/rhabdoid tumor arising in a malignant glioma
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Atypical teratoid/rhabdoid tumor arising in a malignant glioma. / Bozzai, Barbara; Hasselblatt, Martin; Turányi, Eszter; Frühwald, Michael C; Siebert, Reiner; Bens, Susanne; Schneppenheim, Reinhard; Kool, Marcel; Stelczer, Gábor; Hortobágyi, Tibor; Hauser, Peter.
In: PEDIATR BLOOD CANCER, Vol. 64, No. 1, 01.2017, p. 96-99.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Atypical teratoid/rhabdoid tumor arising in a malignant glioma
AU - Bozzai, Barbara
AU - Hasselblatt, Martin
AU - Turányi, Eszter
AU - Frühwald, Michael C
AU - Siebert, Reiner
AU - Bens, Susanne
AU - Schneppenheim, Reinhard
AU - Kool, Marcel
AU - Stelczer, Gábor
AU - Hortobágyi, Tibor
AU - Hauser, Peter
N1 - © 2016 Wiley Periodicals, Inc.
PY - 2017/1
Y1 - 2017/1
N2 - Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.
AB - Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.
KW - Child, Preschool
KW - Combined Modality Therapy
KW - Female
KW - Glioma
KW - Humans
KW - Neoplasm Recurrence, Local
KW - Neoplasm Staging
KW - Neoplasms, Second Primary
KW - Prognosis
KW - Rhabdoid Tumor
KW - Teratoma
KW - Case Reports
KW - Journal Article
U2 - 10.1002/pbc.26173
DO - 10.1002/pbc.26173
M3 - SCORING: Journal article
C2 - 27472468
VL - 64
SP - 96
EP - 99
JO - PEDIATR BLOOD CANCER
JF - PEDIATR BLOOD CANCER
SN - 1545-5009
IS - 1
ER -