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Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils

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Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils. / Kozik, Jan-Hendrik; Trautmann, Tanja; Carambia, Antonella; Preti, Max; Lütgehetmann, Marc; Krech, Till; Wiegard, Christiane; Heeren, Joerg; Herkel, Johannes.

In: SCI REP-UK, Vol. 6, 2016, p. 28556.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kozik, J-H, Trautmann, T, Carambia, A, Preti, M, Lütgehetmann, M, Krech, T, Wiegard, C, Heeren, J & Herkel, J 2016, 'Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils', SCI REP-UK, vol. 6, pp. 28556. https://doi.org/10.1038/srep28556

APA

Kozik, J-H., Trautmann, T., Carambia, A., Preti, M., Lütgehetmann, M., Krech, T., Wiegard, C., Heeren, J., & Herkel, J. (2016). Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils. SCI REP-UK, 6, 28556. https://doi.org/10.1038/srep28556

Vancouver

Kozik J-H, Trautmann T, Carambia A, Preti M, Lütgehetmann M, Krech T et al. Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils. SCI REP-UK. 2016;6:28556. https://doi.org/10.1038/srep28556

Bibtex

@article{2c360c2c410546028e90ad5795f4787a,
title = "Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils",
abstract = "TREM1 (Triggering Receptor Expressed on Myeloid Cells 1) is a pro-inflammatory receptor expressed by phagocytes, which can also be released as a soluble molecule (sTREM1). The roles of TREM1 and sTREM1 in liver infection and inflammation are not clear. Here we show that patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection manifest elevated serum levels of sTREM1. In mice, experimental viral hepatitis induced by infection with Lymphocytic Choriomeningitis Virus (LCMV)-WE was likewise associated with increased sTREM1 in serum and urine, and with increased TREM1 and its associated adapter molecule DAP12 in the liver. Trem1-/- mice showed accelerated clearance of LCMV-WE and manifested attenuated liver inflammation and injury. TREM1 expression in the liver of wild-type mice was mostly confined to infiltrating neutrophils, which responded to LCMV by secretion of CCL2 and TNF-α, and release of sTREM1. Accordingly, the production of CCL2 and TNF-α was decreased in the livers of LCMV-infected Trem1-/- mice, as compared to LCMV-infected wildtype mice. These findings indicate that TREM1 plays a role in viral hepatitis, in which it seems to aggravate the immunopathology associated with viral clearance, mainly by increasing the inflammatory activity of neutrophils.",
author = "Jan-Hendrik Kozik and Tanja Trautmann and Antonella Carambia and Max Preti and Marc L{\"u}tgehetmann and Till Krech and Christiane Wiegard and Joerg Heeren and Johannes Herkel",
year = "2016",
doi = "10.1038/srep28556",
language = "English",
volume = "6",
pages = "28556",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils

AU - Kozik, Jan-Hendrik

AU - Trautmann, Tanja

AU - Carambia, Antonella

AU - Preti, Max

AU - Lütgehetmann, Marc

AU - Krech, Till

AU - Wiegard, Christiane

AU - Heeren, Joerg

AU - Herkel, Johannes

PY - 2016

Y1 - 2016

N2 - TREM1 (Triggering Receptor Expressed on Myeloid Cells 1) is a pro-inflammatory receptor expressed by phagocytes, which can also be released as a soluble molecule (sTREM1). The roles of TREM1 and sTREM1 in liver infection and inflammation are not clear. Here we show that patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection manifest elevated serum levels of sTREM1. In mice, experimental viral hepatitis induced by infection with Lymphocytic Choriomeningitis Virus (LCMV)-WE was likewise associated with increased sTREM1 in serum and urine, and with increased TREM1 and its associated adapter molecule DAP12 in the liver. Trem1-/- mice showed accelerated clearance of LCMV-WE and manifested attenuated liver inflammation and injury. TREM1 expression in the liver of wild-type mice was mostly confined to infiltrating neutrophils, which responded to LCMV by secretion of CCL2 and TNF-α, and release of sTREM1. Accordingly, the production of CCL2 and TNF-α was decreased in the livers of LCMV-infected Trem1-/- mice, as compared to LCMV-infected wildtype mice. These findings indicate that TREM1 plays a role in viral hepatitis, in which it seems to aggravate the immunopathology associated with viral clearance, mainly by increasing the inflammatory activity of neutrophils.

AB - TREM1 (Triggering Receptor Expressed on Myeloid Cells 1) is a pro-inflammatory receptor expressed by phagocytes, which can also be released as a soluble molecule (sTREM1). The roles of TREM1 and sTREM1 in liver infection and inflammation are not clear. Here we show that patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection manifest elevated serum levels of sTREM1. In mice, experimental viral hepatitis induced by infection with Lymphocytic Choriomeningitis Virus (LCMV)-WE was likewise associated with increased sTREM1 in serum and urine, and with increased TREM1 and its associated adapter molecule DAP12 in the liver. Trem1-/- mice showed accelerated clearance of LCMV-WE and manifested attenuated liver inflammation and injury. TREM1 expression in the liver of wild-type mice was mostly confined to infiltrating neutrophils, which responded to LCMV by secretion of CCL2 and TNF-α, and release of sTREM1. Accordingly, the production of CCL2 and TNF-α was decreased in the livers of LCMV-infected Trem1-/- mice, as compared to LCMV-infected wildtype mice. These findings indicate that TREM1 plays a role in viral hepatitis, in which it seems to aggravate the immunopathology associated with viral clearance, mainly by increasing the inflammatory activity of neutrophils.

U2 - 10.1038/srep28556

DO - 10.1038/srep28556

M3 - SCORING: Journal article

C2 - 27328755

VL - 6

SP - 28556

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

ER -