Atrial fibrillation begets atrial fibrillation in the pulmonary veins on the impact of atrial fibrillation on the electrophysiological properties of the pulmonary veins in humans
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Atrial fibrillation begets atrial fibrillation in the pulmonary veins on the impact of atrial fibrillation on the electrophysiological properties of the pulmonary veins in humans. / Rostock, Thomas; Steven, Daniel; Lutomsky, Boris; Servatius, Helge; Drewitz, Imke; Klemm, Hanno; Müllerleile, Kai; Ventura, Rodolfo; Meinertz, Thomas; Willems, Stephan.
In: J AM COLL CARDIOL, Vol. 51, No. 22, 03.06.2008, p. 2153-2160.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Atrial fibrillation begets atrial fibrillation in the pulmonary veins on the impact of atrial fibrillation on the electrophysiological properties of the pulmonary veins in humans
AU - Rostock, Thomas
AU - Steven, Daniel
AU - Lutomsky, Boris
AU - Servatius, Helge
AU - Drewitz, Imke
AU - Klemm, Hanno
AU - Müllerleile, Kai
AU - Ventura, Rodolfo
AU - Meinertz, Thomas
AU - Willems, Stephan
PY - 2008/6/3
Y1 - 2008/6/3
N2 - OBJECTIVES: Our purpose was to investigate the impact of short-lasting atrial fibrillation (AF) on the electrophysiological properties of the atria and pulmonary veins (PVs) in patients devoid of AF.BACKGROUND: The presence of AF is associated with electrical remodeling processes that promote a substrate for arrhythmia maintenance in the atria, which has been termed "AF begets AF." However, it is unclear whether those electrical alterations also occur in the PVs.METHODS: Thirty-five patients with a left-sided accessory pathway and without a prior history of AF were included. After successful ablation, the effective refractory periods (ERPs) and conduction times of the right atrium (RA), left atrium (LA), and the PVs were determined. Afterwards, AF was induced and maintained for a period of 15 min. Thereafter, the stimulation protocol was repeated.RESULTS: At baseline, the PVs had significantly longer ERPs than the atria. After exposure to AF, the ERPs of both the atria and the PVs decreased significantly. The ERPs of the PVs, however, decreased by a significantly greater extent than the ERPs of the atria (PVs: 248 +/- 27 ms vs. 211 +/- 40 ms, p < 0.001; LA: 233 +/- 23 ms vs. 214 +/- 20 ms, p = 0.004; RA: 226 +/- 29 ms vs. 188 +/- 20 ms; p = 0.003). After AF exposure, the PVs demonstrated a significant conduction slowing whereas the atria did not (PVs: 125 +/- 33 ms vs. 159 +/- 37 ms, p < 0.001; LA: 129 +/- 26 ms vs. 130 +/- 24 ms, p = NS; RA: 192 +/- 36 ms vs. 196 +/- 32 ms, p = NS). Finally, AF was more frequently induced after the presence of AF, particularly by pacing in the PVs (14% vs. 49%, p = 0.001).CONCLUSIONS: New-onset, short-lasting AF creates electrical characteristics similar to those of patients with AF. However, these alterations are pronounced in the PVs compared with the atria, indicating that "AF begets AF in the PVs" (Electrophysiological Properties of the Pulmonary Veins; NCT00530608).
AB - OBJECTIVES: Our purpose was to investigate the impact of short-lasting atrial fibrillation (AF) on the electrophysiological properties of the atria and pulmonary veins (PVs) in patients devoid of AF.BACKGROUND: The presence of AF is associated with electrical remodeling processes that promote a substrate for arrhythmia maintenance in the atria, which has been termed "AF begets AF." However, it is unclear whether those electrical alterations also occur in the PVs.METHODS: Thirty-five patients with a left-sided accessory pathway and without a prior history of AF were included. After successful ablation, the effective refractory periods (ERPs) and conduction times of the right atrium (RA), left atrium (LA), and the PVs were determined. Afterwards, AF was induced and maintained for a period of 15 min. Thereafter, the stimulation protocol was repeated.RESULTS: At baseline, the PVs had significantly longer ERPs than the atria. After exposure to AF, the ERPs of both the atria and the PVs decreased significantly. The ERPs of the PVs, however, decreased by a significantly greater extent than the ERPs of the atria (PVs: 248 +/- 27 ms vs. 211 +/- 40 ms, p < 0.001; LA: 233 +/- 23 ms vs. 214 +/- 20 ms, p = 0.004; RA: 226 +/- 29 ms vs. 188 +/- 20 ms; p = 0.003). After AF exposure, the PVs demonstrated a significant conduction slowing whereas the atria did not (PVs: 125 +/- 33 ms vs. 159 +/- 37 ms, p < 0.001; LA: 129 +/- 26 ms vs. 130 +/- 24 ms, p = NS; RA: 192 +/- 36 ms vs. 196 +/- 32 ms, p = NS). Finally, AF was more frequently induced after the presence of AF, particularly by pacing in the PVs (14% vs. 49%, p = 0.001).CONCLUSIONS: New-onset, short-lasting AF creates electrical characteristics similar to those of patients with AF. However, these alterations are pronounced in the PVs compared with the atria, indicating that "AF begets AF in the PVs" (Electrophysiological Properties of the Pulmonary Veins; NCT00530608).
KW - Adult
KW - Atrial Fibrillation/physiopathology
KW - Catheter Ablation/methods
KW - Coronary Vessels/physiopathology
KW - Electrophysiology
KW - Female
KW - Heart Atria/physiopathology
KW - Heart Conduction System/physiopathology
KW - Humans
KW - Male
KW - Prospective Studies
KW - Pulmonary Veins/physiopathology
KW - Time Factors
U2 - 10.1016/j.jacc.2008.02.059
DO - 10.1016/j.jacc.2008.02.059
M3 - SCORING: Journal article
C2 - 18510963
VL - 51
SP - 2153
EP - 2160
JO - J AM COLL CARDIOL
JF - J AM COLL CARDIOL
SN - 0735-1097
IS - 22
ER -
