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Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction

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Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction. / Carnicelli, Anthony P; Owen, Ruth; Pocock, Stuart J; Brieger, David B; Yasuda, Satoshi; Nicolau, Jose Carlos; Goodman, Shaun G; Cohen, Mauricio G; Simon, Tabassome; Westermann, Dirk; Hedman, Katarina; Andersson Sundell, Karolina; Granger, Christopher B.

In: OPEN HEART, Vol. 8, No. 2, e001726, 12.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Carnicelli, AP, Owen, R, Pocock, SJ, Brieger, DB, Yasuda, S, Nicolau, JC, Goodman, SG, Cohen, MG, Simon, T, Westermann, D, Hedman, K, Andersson Sundell, K & Granger, CB 2021, 'Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction', OPEN HEART, vol. 8, no. 2, e001726. https://doi.org/10.1136/openhrt-2021-001726

APA

Carnicelli, A. P., Owen, R., Pocock, S. J., Brieger, D. B., Yasuda, S., Nicolau, J. C., Goodman, S. G., Cohen, M. G., Simon, T., Westermann, D., Hedman, K., Andersson Sundell, K., & Granger, C. B. (2021). Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction. OPEN HEART, 8(2), [e001726]. https://doi.org/10.1136/openhrt-2021-001726

Vancouver

Carnicelli AP, Owen R, Pocock SJ, Brieger DB, Yasuda S, Nicolau JC et al. Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction. OPEN HEART. 2021 Dec;8(2). e001726. https://doi.org/10.1136/openhrt-2021-001726

Bibtex

@article{df3b601ae29d43b98ed0576a4b7be22e,
title = "Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction",
abstract = "OBJECTIVE: Atrial fibrillation (AF) and myocardial infarction (MI) are commonly comorbid and associated with adverse outcomes. Little is known about the impact of AF on quality of life and outcomes post-MI. We compared characteristics, quality of life and clinical outcomes in stable patients post-MI with/without AF.METHODS/RESULTS: The prospective, international, observational TIGRIS (long Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease) registry included 8406 patients aged ≥50 years with ≥1 atherothrombotic risk factor who were 1-3 years post-MI. Patient characteristics were summarised by history of AF. Quality of life was assessed at baseline using EQ-5D. Clinical outcomes over 2 years of follow-up were compared. History of AF was present in 702/8277 (8.5%) registry patients and incident AF was diagnosed in 244/7575 (3.2%) over 2 years. Those with AF were older and had more comorbidities than those without AF. After multivariable adjustment, patients with AF had lower self-reported quality-of-life scores (EQ-5D UK-weighted index, visual analogue scale, usual activities and pain/discomfort) than those without AF. CHA2DS2-VASc score ≥2 was present in 686/702 (97.7%) patients with AF, although only 348/702 (49.6%) were on oral anticoagulants at enrolment. Patients with AF had higher rates of all-cause hospitalisation (adjusted rate ratio 1.25 [1.06-1.46], p=0.008) over 2 years than those without AF, but similar rates of mortality.CONCLUSIONS: In stable patients post-MI, those with AF were commonly undertreated with oral anticoagulants, had poorer quality of life and had increased risk of clinical outcomes than those without AF.TRIAL REGISTRATION NUMBER: ClinicalTrials: NCT01866904.",
keywords = "Administration, Oral, Aged, Anticoagulants/administration & dosage, Atrial Fibrillation/drug therapy, Female, Follow-Up Studies, Global Health, Humans, Male, Myocardial Infarction/complications, Prevalence, Prospective Studies, Quality of Life, Registries, Survival Rate/trends, Time Factors",
author = "Carnicelli, {Anthony P} and Ruth Owen and Pocock, {Stuart J} and Brieger, {David B} and Satoshi Yasuda and Nicolau, {Jose Carlos} and Goodman, {Shaun G} and Cohen, {Mauricio G} and Tabassome Simon and Dirk Westermann and Katarina Hedman and {Andersson Sundell}, Karolina and Granger, {Christopher B}",
note = "{\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2021",
month = dec,
doi = "10.1136/openhrt-2021-001726",
language = "English",
volume = "8",
journal = "OPEN HEART",
issn = "2053-3624",
publisher = "BMJ PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction

AU - Carnicelli, Anthony P

AU - Owen, Ruth

AU - Pocock, Stuart J

AU - Brieger, David B

AU - Yasuda, Satoshi

AU - Nicolau, Jose Carlos

AU - Goodman, Shaun G

AU - Cohen, Mauricio G

AU - Simon, Tabassome

AU - Westermann, Dirk

AU - Hedman, Katarina

AU - Andersson Sundell, Karolina

AU - Granger, Christopher B

N1 - © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021/12

Y1 - 2021/12

N2 - OBJECTIVE: Atrial fibrillation (AF) and myocardial infarction (MI) are commonly comorbid and associated with adverse outcomes. Little is known about the impact of AF on quality of life and outcomes post-MI. We compared characteristics, quality of life and clinical outcomes in stable patients post-MI with/without AF.METHODS/RESULTS: The prospective, international, observational TIGRIS (long Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease) registry included 8406 patients aged ≥50 years with ≥1 atherothrombotic risk factor who were 1-3 years post-MI. Patient characteristics were summarised by history of AF. Quality of life was assessed at baseline using EQ-5D. Clinical outcomes over 2 years of follow-up were compared. History of AF was present in 702/8277 (8.5%) registry patients and incident AF was diagnosed in 244/7575 (3.2%) over 2 years. Those with AF were older and had more comorbidities than those without AF. After multivariable adjustment, patients with AF had lower self-reported quality-of-life scores (EQ-5D UK-weighted index, visual analogue scale, usual activities and pain/discomfort) than those without AF. CHA2DS2-VASc score ≥2 was present in 686/702 (97.7%) patients with AF, although only 348/702 (49.6%) were on oral anticoagulants at enrolment. Patients with AF had higher rates of all-cause hospitalisation (adjusted rate ratio 1.25 [1.06-1.46], p=0.008) over 2 years than those without AF, but similar rates of mortality.CONCLUSIONS: In stable patients post-MI, those with AF were commonly undertreated with oral anticoagulants, had poorer quality of life and had increased risk of clinical outcomes than those without AF.TRIAL REGISTRATION NUMBER: ClinicalTrials: NCT01866904.

AB - OBJECTIVE: Atrial fibrillation (AF) and myocardial infarction (MI) are commonly comorbid and associated with adverse outcomes. Little is known about the impact of AF on quality of life and outcomes post-MI. We compared characteristics, quality of life and clinical outcomes in stable patients post-MI with/without AF.METHODS/RESULTS: The prospective, international, observational TIGRIS (long Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease) registry included 8406 patients aged ≥50 years with ≥1 atherothrombotic risk factor who were 1-3 years post-MI. Patient characteristics were summarised by history of AF. Quality of life was assessed at baseline using EQ-5D. Clinical outcomes over 2 years of follow-up were compared. History of AF was present in 702/8277 (8.5%) registry patients and incident AF was diagnosed in 244/7575 (3.2%) over 2 years. Those with AF were older and had more comorbidities than those without AF. After multivariable adjustment, patients with AF had lower self-reported quality-of-life scores (EQ-5D UK-weighted index, visual analogue scale, usual activities and pain/discomfort) than those without AF. CHA2DS2-VASc score ≥2 was present in 686/702 (97.7%) patients with AF, although only 348/702 (49.6%) were on oral anticoagulants at enrolment. Patients with AF had higher rates of all-cause hospitalisation (adjusted rate ratio 1.25 [1.06-1.46], p=0.008) over 2 years than those without AF, but similar rates of mortality.CONCLUSIONS: In stable patients post-MI, those with AF were commonly undertreated with oral anticoagulants, had poorer quality of life and had increased risk of clinical outcomes than those without AF.TRIAL REGISTRATION NUMBER: ClinicalTrials: NCT01866904.

KW - Administration, Oral

KW - Aged

KW - Anticoagulants/administration & dosage

KW - Atrial Fibrillation/drug therapy

KW - Female

KW - Follow-Up Studies

KW - Global Health

KW - Humans

KW - Male

KW - Myocardial Infarction/complications

KW - Prevalence

KW - Prospective Studies

KW - Quality of Life

KW - Registries

KW - Survival Rate/trends

KW - Time Factors

U2 - 10.1136/openhrt-2021-001726

DO - 10.1136/openhrt-2021-001726

M3 - SCORING: Journal article

C2 - 34911791

VL - 8

JO - OPEN HEART

JF - OPEN HEART

SN - 2053-3624

IS - 2

M1 - e001726

ER -