Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study

TY - JOUR

T1 - Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the Framingham Heart Study

AU - Hong, Susie N

AU - Gona, Philimon

AU - Fontes, Joao D

AU - Oyama, Noriko

AU - Chan, Raymond H

AU - Kenchaiah, Satish

AU - Tsao, Connie W

AU - Yeon, Susan B

AU - Schnabel, Renate B

AU - Keaney, John F

AU - O'Donnell, Christopher J

AU - Benjamin, Emelia J

AU - Manning, Warren J

PY - 2013/11/15

Y1 - 2013/11/15

N2 - BACKGROUND: The relations between subclinical atherosclerosis and inflammatory biomarkers have generated intense interest but their significance remains unclear. We sought to determine the association between a panel of biomarkers and subclinical aortic atherosclerosis in a community-based cohort.METHODS AND RESULTS: We evaluated 1547 participants of the Framingham Heart Study Offspring cohort who attended the 7th examination cycle and underwent both cardiovascular magnetic resonance imaging (CMR) and assays for 10 biomarkers associated with atherosclerosis: high-sensitivity C-reactive protein, fibrinogen, intercellular adhesion molecule-1, interleukin-6, interleukin-18, lipoprotein-associated phospholipase-A2 activity and mass, monocyte chemoattractant protein-1, P-selectin, and tumor necrosis factor receptor-2. In logistic regression analysis, we found no significant association between the biomarker panel and the presence of aortic plaque (global P=0.53). Using Tobit regression with aortic plaque as a continuous variable, we noted a modest association between biomarker panel and aortic plaque volume in age- and sex-adjusted analyses (P=0.003). However, this association was attenuated after further adjustment for clinical covariates (P=0.09).CONCLUSIONS: In our community-based cohort, we found no significant association between our multibiomarker panel and aortic plaque. Our results underscore the strengths and limitations of the use of biomarkers for the identification of subclinical atherosclerosis and the importance of traditional risk factors.

AB - BACKGROUND: The relations between subclinical atherosclerosis and inflammatory biomarkers have generated intense interest but their significance remains unclear. We sought to determine the association between a panel of biomarkers and subclinical aortic atherosclerosis in a community-based cohort.METHODS AND RESULTS: We evaluated 1547 participants of the Framingham Heart Study Offspring cohort who attended the 7th examination cycle and underwent both cardiovascular magnetic resonance imaging (CMR) and assays for 10 biomarkers associated with atherosclerosis: high-sensitivity C-reactive protein, fibrinogen, intercellular adhesion molecule-1, interleukin-6, interleukin-18, lipoprotein-associated phospholipase-A2 activity and mass, monocyte chemoattractant protein-1, P-selectin, and tumor necrosis factor receptor-2. In logistic regression analysis, we found no significant association between the biomarker panel and the presence of aortic plaque (global P=0.53). Using Tobit regression with aortic plaque as a continuous variable, we noted a modest association between biomarker panel and aortic plaque volume in age- and sex-adjusted analyses (P=0.003). However, this association was attenuated after further adjustment for clinical covariates (P=0.09).CONCLUSIONS: In our community-based cohort, we found no significant association between our multibiomarker panel and aortic plaque. Our results underscore the strengths and limitations of the use of biomarkers for the identification of subclinical atherosclerosis and the importance of traditional risk factors.

KW - Age Factors

KW - Aged

KW - Aorta, Abdominal/pathology

KW - Aorta, Thoracic/pathology

KW - Aortic Diseases/blood

KW - Atherosclerosis/blood

KW - Biomarkers/blood

KW - Female

KW - Humans

KW - Inflammation Mediators/blood

KW - Magnetic Resonance Imaging

KW - Male

KW - Massachusetts

KW - Middle Aged

KW - Plaque, Atherosclerotic

KW - Predictive Value of Tests

KW - Prognosis

KW - Risk Factors

KW - Sex Factors

U2 - 10.1161/JAHA.113.000307

DO - 10.1161/JAHA.113.000307

M3 - SCORING: Journal article

C2 - 24242683

VL - 2

SP - e000307

JO - J AM HEART ASSOC

JF - J AM HEART ASSOC

SN - 2047-9980

IS - 6

ER -