Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease.
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Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease. / Spoto, Belinda; Benedetto, Francesco A; Testa, Alessandra; Tripepi, Giovanni; Mallamaci, Francesca; Maas, Renke; Boeger, Rainer H; Zoccali, Carmine; Parlongo, Rosa Maria; Pisano, Anna.
In: AM J HYPERTENS, Vol. 18(12 Pt 1), 2005, p. 1549-1555.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease.
AU - Spoto, Belinda
AU - Benedetto, Francesco A
AU - Testa, Alessandra
AU - Tripepi, Giovanni
AU - Mallamaci, Francesca
AU - Maas, Renke
AU - Boeger, Rainer H
AU - Zoccali, Carmine
AU - Parlongo, Rosa Maria
AU - Pisano, Anna
PY - 2005
Y1 - 2005
N2 - BACKGROUND: We investigated whether the eNOS G/T polymorphism (Glu298Asp variant) is linked to the severity of carotid atherosclerosis and whether it is independent of asymmetric dimethylarginine (ADMA) in determining vascular damage in patients with end-stage renal disease (ESRD). METHODS: The eNOS polymorphism, ADMA, carotid intima-media thickness (IMT), and carotid artery (CCA) wall-to-lumen ratio (an indicator of arterial remodeling) were determined/measured in 131 patients with ESRD. RESULTS: Both in the co-dominant and dominant model approach, IMT as well as CCA wall-to-lumen ratio were directly related to the T allele (P <or = .009) and these relationships held true in multiple linear regression analyses including ADMA and traditional and emerging risk factors. The relationship between eNOS genotypes and CCA wall-to-lumen ratio was further analyzed by a categorical approach and in a multiple logistic regression analysis, the odds ratio (OR) of increased CCA wall-to-lumen ratio was strongly associated to the T allele (codominant model: GG, OR = 1; GT, OR = 2.1; TT, OR = 8.2; P for trend = .01; dominant model: GG, OR = 1; GT and TT, OR = 2.7; P = .02). CONCLUSIONS: The T allele of eNOS gene is an independent predictor of intimal lesions and vascular remodeling and it is associated with the severity of atherosclerosis independently of ADMA.
AB - BACKGROUND: We investigated whether the eNOS G/T polymorphism (Glu298Asp variant) is linked to the severity of carotid atherosclerosis and whether it is independent of asymmetric dimethylarginine (ADMA) in determining vascular damage in patients with end-stage renal disease (ESRD). METHODS: The eNOS polymorphism, ADMA, carotid intima-media thickness (IMT), and carotid artery (CCA) wall-to-lumen ratio (an indicator of arterial remodeling) were determined/measured in 131 patients with ESRD. RESULTS: Both in the co-dominant and dominant model approach, IMT as well as CCA wall-to-lumen ratio were directly related to the T allele (P <or = .009) and these relationships held true in multiple linear regression analyses including ADMA and traditional and emerging risk factors. The relationship between eNOS genotypes and CCA wall-to-lumen ratio was further analyzed by a categorical approach and in a multiple logistic regression analysis, the odds ratio (OR) of increased CCA wall-to-lumen ratio was strongly associated to the T allele (codominant model: GG, OR = 1; GT, OR = 2.1; TT, OR = 8.2; P for trend = .01; dominant model: GG, OR = 1; GT and TT, OR = 2.7; P = .02). CONCLUSIONS: The T allele of eNOS gene is an independent predictor of intimal lesions and vascular remodeling and it is associated with the severity of atherosclerosis independently of ADMA.
M3 - SCORING: Zeitschriftenaufsatz
VL - 18(12 Pt 1)
SP - 1549
EP - 1555
JO - AM J HYPERTENS
JF - AM J HYPERTENS
SN - 0895-7061
ER -
