Research ExplorerPublicationsAsymmetric dimethyl-arginine and coronary artery calcificati...

Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study

Standard

Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study. / Iribarren, Carlos; Husson, Gail; Sydow, Karsten; Wang, Bing-Yin; Sidney, Stephen; Cooke, John P.

In: EUR J PREV CARDIOL, Vol. 14, No. 2, 04.2007, p. 222-229.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Iribarren, C, Husson, G, Sydow, K, Wang, B-Y, Sidney, S & Cooke, JP 2007, 'Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study', EUR J PREV CARDIOL, vol. 14, no. 2, pp. 222-229. https://doi.org/10.1097/01.hjr.0000230108.86147.40

APA

Iribarren, C., Husson, G., Sydow, K., Wang, B-Y., Sidney, S., & Cooke, J. P. (2007). Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study. EUR J PREV CARDIOL, 14(2), 222-229. https://doi.org/10.1097/01.hjr.0000230108.86147.40

Vancouver

Iribarren C, Husson G, Sydow K, Wang B-Y, Sidney S, Cooke JP. Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study. EUR J PREV CARDIOL. 2007 Apr;14(2):222-229. https://doi.org/10.1097/01.hjr.0000230108.86147.40

Bibtex

@article{51679984283242ab88c4d773782e9919,
title = "Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study",
abstract = "BACKGROUND: Normal endothelial function depends on nitric oxide (NO) release by endothelial cells. Asymmetric dimethylarginine (ADMA), by competing with L-arginine, inhibits NO production and may lead to endothelial dysfunction and atherosclerotic development. Our aim was to ascertain the association between ADMA and coronary artery calcification (CAC), a marker of atherosclerotic coronary disease burden.DESIGN: A nested case-control study within the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, an observational study among young adults residing in four US cities.METHODS: Participants were 263 white and black male and female cases with the presence of CAC and 263 sex and race-matched controls without evidence of CAC by computed tomography, 33-47 years old in 2000-2001.RESULTS: The median level (range) of ADMA was significantly higher in cases (0.55; 0.20-2.22 micromol/l) than in controls (0.53; 0.32-1.30 micromol/l; P=0.03). In conditional logistic regression adjusting for age, field center, educational attainment, smoking status, alcohol consumption, body mass index, waist circumference, hypertension, diabetes, low-density lipoprotein and high-density lipoprotein-cholesterol, triglycerides, renal function and C-reactive protein, the highest tertile of ADMA, compared with the lowest tertile, was associated with 1.80 (95% confidence interval 1.03-3.15) increased odds of the presence of any CAC. By linear regression, a significant independent relationship was also found between ADMA and the degree of CAC.CONCLUSION: These results support a role for ADMA as a biochemical marker of CAC.",
keywords = "Adult, Analysis of Variance, Arginine/analogs & derivatives, Biomarkers/blood, Calcinosis/blood, Case-Control Studies, Coronary Artery Disease/blood, Endothelium, Vascular/metabolism, Enzyme-Linked Immunosorbent Assay, Female, Humans, Linear Models, Logistic Models, Male, Middle Aged, Research Design, Risk Factors, Tomography, X-Ray Computed, Treatment Outcome",
author = "Carlos Iribarren and Gail Husson and Karsten Sydow and Bing-Yin Wang and Stephen Sidney and Cooke, {John P}",
year = "2007",
month = apr,
doi = "10.1097/01.hjr.0000230108.86147.40",
language = "English",
volume = "14",
pages = "222--229",
journal = "EUR J PREV CARDIOL",
issn = "2047-4873",
publisher = "SAGE Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study

AU - Iribarren, Carlos

AU - Husson, Gail

AU - Sydow, Karsten

AU - Wang, Bing-Yin

AU - Sidney, Stephen

AU - Cooke, John P

PY - 2007/4

Y1 - 2007/4

N2 - BACKGROUND: Normal endothelial function depends on nitric oxide (NO) release by endothelial cells. Asymmetric dimethylarginine (ADMA), by competing with L-arginine, inhibits NO production and may lead to endothelial dysfunction and atherosclerotic development. Our aim was to ascertain the association between ADMA and coronary artery calcification (CAC), a marker of atherosclerotic coronary disease burden.DESIGN: A nested case-control study within the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, an observational study among young adults residing in four US cities.METHODS: Participants were 263 white and black male and female cases with the presence of CAC and 263 sex and race-matched controls without evidence of CAC by computed tomography, 33-47 years old in 2000-2001.RESULTS: The median level (range) of ADMA was significantly higher in cases (0.55; 0.20-2.22 micromol/l) than in controls (0.53; 0.32-1.30 micromol/l; P=0.03). In conditional logistic regression adjusting for age, field center, educational attainment, smoking status, alcohol consumption, body mass index, waist circumference, hypertension, diabetes, low-density lipoprotein and high-density lipoprotein-cholesterol, triglycerides, renal function and C-reactive protein, the highest tertile of ADMA, compared with the lowest tertile, was associated with 1.80 (95% confidence interval 1.03-3.15) increased odds of the presence of any CAC. By linear regression, a significant independent relationship was also found between ADMA and the degree of CAC.CONCLUSION: These results support a role for ADMA as a biochemical marker of CAC.

AB - BACKGROUND: Normal endothelial function depends on nitric oxide (NO) release by endothelial cells. Asymmetric dimethylarginine (ADMA), by competing with L-arginine, inhibits NO production and may lead to endothelial dysfunction and atherosclerotic development. Our aim was to ascertain the association between ADMA and coronary artery calcification (CAC), a marker of atherosclerotic coronary disease burden.DESIGN: A nested case-control study within the Coronary Artery Risk Development in Young Adults (CARDIA) cohort, an observational study among young adults residing in four US cities.METHODS: Participants were 263 white and black male and female cases with the presence of CAC and 263 sex and race-matched controls without evidence of CAC by computed tomography, 33-47 years old in 2000-2001.RESULTS: The median level (range) of ADMA was significantly higher in cases (0.55; 0.20-2.22 micromol/l) than in controls (0.53; 0.32-1.30 micromol/l; P=0.03). In conditional logistic regression adjusting for age, field center, educational attainment, smoking status, alcohol consumption, body mass index, waist circumference, hypertension, diabetes, low-density lipoprotein and high-density lipoprotein-cholesterol, triglycerides, renal function and C-reactive protein, the highest tertile of ADMA, compared with the lowest tertile, was associated with 1.80 (95% confidence interval 1.03-3.15) increased odds of the presence of any CAC. By linear regression, a significant independent relationship was also found between ADMA and the degree of CAC.CONCLUSION: These results support a role for ADMA as a biochemical marker of CAC.

KW - Adult

KW - Analysis of Variance

KW - Arginine/analogs & derivatives

KW - Biomarkers/blood

KW - Calcinosis/blood

KW - Case-Control Studies

KW - Coronary Artery Disease/blood

KW - Endothelium, Vascular/metabolism

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Humans

KW - Linear Models

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Research Design

KW - Risk Factors

KW - Tomography, X-Ray Computed

KW - Treatment Outcome

U2 - 10.1097/01.hjr.0000230108.86147.40

DO - 10.1097/01.hjr.0000230108.86147.40

M3 - SCORING: Journal article

C2 - 17446800

VL - 14

SP - 222

EP - 229

JO - EUR J PREV CARDIOL

JF - EUR J PREV CARDIOL

SN - 2047-4873

IS - 2

ER -