Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease
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Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease. / Lau, Lina Hui Ying; Nano, Jana; Prehn, Cornelia; Cecil, Alexander; Rathmann, Wolfgang; Zeller, Tanja; Lechner, Andreas; Adamski, Jerzy; Peters, Annette; Thorand, Barbara.
In: FRONT ENDOCRINOL, Vol. 13, 1000650, 2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease
AU - Lau, Lina Hui Ying
AU - Nano, Jana
AU - Prehn, Cornelia
AU - Cecil, Alexander
AU - Rathmann, Wolfgang
AU - Zeller, Tanja
AU - Lechner, Andreas
AU - Adamski, Jerzy
AU - Peters, Annette
AU - Thorand, Barbara
N1 - Copyright © 2022 Lau, Nano, Prehn, Cecil, Rathmann, Zeller, Lechner, Adamski, Peters and Thorand.
PY - 2022
Y1 - 2022
N2 - INTRODUCTION: The role of endogenous androgens in kidney function and disease has not been extensively explored in men and women.RESEARCH DESIGN AND METHODS: We analyzed data from the observational KORA F4 study and its follow-up examination KORA FF4 (median follow-up time 6.5 years) including 1293 men and 650 peri- and postmenopausal women, not using exogenous sex hormones. We examined the associations between endogenous androgens (testosterone [T], dihydrotestosterone [DHT], free T [fT], free DHT [fDHT], and T/DHT), with estimated glomerular filtration rate (eGFR) at baseline and follow-up, prevalent, and incident chronic kidney disease (CKD) adjusting for common CKD risk factors.RESULTS: At baseline, 73 men (5.7%) and 54 women (8.4%) had prevalent CKD. Cross-sectionally, no significant associations between androgens and kidney function were observed among men. In women, elevated T (β=-1.305, [95% CI -2.290; -0.320]) and fT (β=-1.423, [95% CI -2.449; -0.397]) were associated with lower eGFR. Prospectively, 81 men (8.8%) and 60 women (15.2%) developed incident CKD. In women, a reverse J-shaped associations was observed between DHT and incident CKD (Pnon-linear=0.029), while higher fDHT was associated with lower incident CKD risk (odds ratio per 1 standard deviation=0.613, [95% CI 0.369; 0.971]. Among men, T/DHT (β=-0.819, [95% CI -1.413; -0.226]) and SHBG (Pnon-linear=0.011) were associated with eGFR at follow-up but not with incident CKD. Some associations appeared to be modified by type 2 diabetes (T2D).CONCLUSION: Suggestive associations are observed of androgens and SHBG with kidney impairment among men and women. However, larger well-phenotyped prospective studies are required to further elucidate the potential of androgens, SHBG, and T2D as modifiable risk factors for kidney function and CKD.
AB - INTRODUCTION: The role of endogenous androgens in kidney function and disease has not been extensively explored in men and women.RESEARCH DESIGN AND METHODS: We analyzed data from the observational KORA F4 study and its follow-up examination KORA FF4 (median follow-up time 6.5 years) including 1293 men and 650 peri- and postmenopausal women, not using exogenous sex hormones. We examined the associations between endogenous androgens (testosterone [T], dihydrotestosterone [DHT], free T [fT], free DHT [fDHT], and T/DHT), with estimated glomerular filtration rate (eGFR) at baseline and follow-up, prevalent, and incident chronic kidney disease (CKD) adjusting for common CKD risk factors.RESULTS: At baseline, 73 men (5.7%) and 54 women (8.4%) had prevalent CKD. Cross-sectionally, no significant associations between androgens and kidney function were observed among men. In women, elevated T (β=-1.305, [95% CI -2.290; -0.320]) and fT (β=-1.423, [95% CI -2.449; -0.397]) were associated with lower eGFR. Prospectively, 81 men (8.8%) and 60 women (15.2%) developed incident CKD. In women, a reverse J-shaped associations was observed between DHT and incident CKD (Pnon-linear=0.029), while higher fDHT was associated with lower incident CKD risk (odds ratio per 1 standard deviation=0.613, [95% CI 0.369; 0.971]. Among men, T/DHT (β=-0.819, [95% CI -1.413; -0.226]) and SHBG (Pnon-linear=0.011) were associated with eGFR at follow-up but not with incident CKD. Some associations appeared to be modified by type 2 diabetes (T2D).CONCLUSION: Suggestive associations are observed of androgens and SHBG with kidney impairment among men and women. However, larger well-phenotyped prospective studies are required to further elucidate the potential of androgens, SHBG, and T2D as modifiable risk factors for kidney function and CKD.
KW - Male
KW - Humans
KW - Female
KW - Androgens
KW - Diabetes Mellitus, Type 2
KW - Sex Hormone-Binding Globulin
KW - Dihydrotestosterone
KW - Renal Insufficiency, Chronic/epidemiology
KW - Kidney
U2 - 10.3389/fendo.2022.1000650
DO - 10.3389/fendo.2022.1000650
M3 - SCORING: Journal article
C2 - 36601008
VL - 13
JO - FRONT ENDOCRINOL
JF - FRONT ENDOCRINOL
SN - 1664-2392
M1 - 1000650
ER -
