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Associations of Change in Body Size With All-Cause and Cause-Specific Mortality Among Healthy Older Adults

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Associations of Change in Body Size With All-Cause and Cause-Specific Mortality Among Healthy Older Adults. / Hussain, Sultana Monira; Newman, Anne B; Beilin, Lawrence J; Tonkin, Andrew M; Woods, Robyn L; Neumann, Johannes T; Nelson, Mark; Carr, Prudence R; Reid, Christopher M; Owen, Alice; Ball, Jocasta; Cicuttini, Flavia M; Tran, Cammie; Wang, Yuanyuan; Ernst, Michael E; McNeil, John J.

In: JAMA NETW OPEN, Vol. 6, No. 4, 03.04.2023, p. e237482.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hussain, SM, Newman, AB, Beilin, LJ, Tonkin, AM, Woods, RL, Neumann, JT, Nelson, M, Carr, PR, Reid, CM, Owen, A, Ball, J, Cicuttini, FM, Tran, C, Wang, Y, Ernst, ME & McNeil, JJ 2023, 'Associations of Change in Body Size With All-Cause and Cause-Specific Mortality Among Healthy Older Adults', JAMA NETW OPEN, vol. 6, no. 4, pp. e237482. https://doi.org/10.1001/jamanetworkopen.2023.7482

APA

Hussain, S. M., Newman, A. B., Beilin, L. J., Tonkin, A. M., Woods, R. L., Neumann, J. T., Nelson, M., Carr, P. R., Reid, C. M., Owen, A., Ball, J., Cicuttini, F. M., Tran, C., Wang, Y., Ernst, M. E., & McNeil, J. J. (2023). Associations of Change in Body Size With All-Cause and Cause-Specific Mortality Among Healthy Older Adults. JAMA NETW OPEN, 6(4), e237482. https://doi.org/10.1001/jamanetworkopen.2023.7482

Vancouver

Hussain SM, Newman AB, Beilin LJ, Tonkin AM, Woods RL, Neumann JT et al. Associations of Change in Body Size With All-Cause and Cause-Specific Mortality Among Healthy Older Adults. JAMA NETW OPEN. 2023 Apr 3;6(4):e237482. https://doi.org/10.1001/jamanetworkopen.2023.7482

Bibtex

@article{38610dc09bc648db9f4617ebcd9e662b,
title = "Associations of Change in Body Size With All-Cause and Cause-Specific Mortality Among Healthy Older Adults",
abstract = "IMPORTANCE: The association between weight change and subsequent cause-specific mortality among older adults is not well described. The significance of changes in waist circumference (WC) has also not been compared with weight change for this purpose.OBJECTIVE: To examine the associations of changes in body weight and WC with all-cause and cause-specific mortality.DESIGN, SETTING, AND PARTICIPANTS: This cohort study is a post hoc analysis of data from the Aspirin in Reducing Events in the Elderly (ASPREE) randomized clinical trial, which recruited participants between March 1, 2010, and December 31, 2014. The study included community-based older adults (16 703 Australian participants aged ≥70 years and 2411 US participants aged ≥65 years) without evident cardiovascular disease (CVD), dementia, physical disability, or life-limiting chronic illness. Data analysis was performed from April to September 2022.EXPOSURES: Body weight and WC were measured at baseline and at annual visit 2. Analysis models were adjusted for baseline body mass index because height and weight were measured at baseline, allowing for calculation of body mass index and other variables. Both body weight and WC changes were categorized as change within 5% (stable), decrease by 5% to 10%, decrease by more than 10%, increase by 5% to 10%, and increase by more than 10%.MAIN OUTCOMES AND MEASURES: All-cause, cancer-specific, CVD-specific, and noncancer non-CVD-specific mortality. Mortality events were adjudicated by an expert review panel. Cox proportional hazards regression and competing risk analyses were used to calculate hazard ratios (HRs) and 95% CIs.RESULTS: Among 16 523 participants (mean [SD] age, 75.0 [4.3] years; 9193 women [55.6%]), 1256 deaths were observed over a mean (SD) of 4.4 (1.7) years. Compared with men with stable weight, those with a 5% to 10% weight loss had a 33% higher (HR, 1.33; 95% CI, 1.07-1.66) risk of all-cause mortality, and those with more than a 10% decrease in body weight had a 289% higher (HR, 3.89; 95% CI, 2.93-5.18) risk. Compared with women with stable weight, those with a 5% to 10% weight loss had a 26% higher (HR, 1.26; 95% CI, 1.00-1.60) risk of all-cause mortality, and those with more than a 10% decrease in body weight had a 114% higher (HR, 2.14; 95% CI, 1.58-2.91) risk. Weight loss was associated with a higher cancer-specific mortality (>10% decrease among men: HR, 3.49; 95% CI, 2.26-5.40; 5%-10% decrease among women: HR, 1.44; 95% CI, 1.46-2.04; >10% decrease among women: HR, 2.78; 95% CI, 1.82-4.26), CVD-specific mortality (>10% decrease among men: HR, 3.14; 95% CI, 1.63-6.04; >10% decrease among women: HR, 1.92; 95% CI, 1.05-3.51), and noncancer non-CVD-specific mortality (>10% decrease among men: HR, 4.98; 95% CI, 3.14-7.91). A decrease in WC was also associated with mortality.CONCLUSIONS AND RELEVANCE: This cohort study of healthy older adults suggests that weight loss was associated with an increase in all-cause and cause-specific mortality, including an increased risk of cancer, CVD, and other life-limiting conditions. Physicians should be aware of the significance of weight loss, especially among older men.",
keywords = "Male, Aged, Humans, Female, Cohort Studies, Cause of Death, Risk Factors, Australia/epidemiology, Cardiovascular Diseases, Weight Loss, Neoplasms, Waist Circumference",
author = "Hussain, {Sultana Monira} and Newman, {Anne B} and Beilin, {Lawrence J} and Tonkin, {Andrew M} and Woods, {Robyn L} and Neumann, {Johannes T} and Mark Nelson and Carr, {Prudence R} and Reid, {Christopher M} and Alice Owen and Jocasta Ball and Cicuttini, {Flavia M} and Cammie Tran and Yuanyuan Wang and Ernst, {Michael E} and McNeil, {John J}",
year = "2023",
month = apr,
day = "3",
doi = "10.1001/jamanetworkopen.2023.7482",
language = "English",
volume = "6",
pages = "e237482",
journal = "JAMA NETW OPEN",
issn = "2574-3805",
publisher = "American Medical Association",
number = "4",

}

RIS

TY - JOUR

T1 - Associations of Change in Body Size With All-Cause and Cause-Specific Mortality Among Healthy Older Adults

AU - Hussain, Sultana Monira

AU - Newman, Anne B

AU - Beilin, Lawrence J

AU - Tonkin, Andrew M

AU - Woods, Robyn L

AU - Neumann, Johannes T

AU - Nelson, Mark

AU - Carr, Prudence R

AU - Reid, Christopher M

AU - Owen, Alice

AU - Ball, Jocasta

AU - Cicuttini, Flavia M

AU - Tran, Cammie

AU - Wang, Yuanyuan

AU - Ernst, Michael E

AU - McNeil, John J

PY - 2023/4/3

Y1 - 2023/4/3

N2 - IMPORTANCE: The association between weight change and subsequent cause-specific mortality among older adults is not well described. The significance of changes in waist circumference (WC) has also not been compared with weight change for this purpose.OBJECTIVE: To examine the associations of changes in body weight and WC with all-cause and cause-specific mortality.DESIGN, SETTING, AND PARTICIPANTS: This cohort study is a post hoc analysis of data from the Aspirin in Reducing Events in the Elderly (ASPREE) randomized clinical trial, which recruited participants between March 1, 2010, and December 31, 2014. The study included community-based older adults (16 703 Australian participants aged ≥70 years and 2411 US participants aged ≥65 years) without evident cardiovascular disease (CVD), dementia, physical disability, or life-limiting chronic illness. Data analysis was performed from April to September 2022.EXPOSURES: Body weight and WC were measured at baseline and at annual visit 2. Analysis models were adjusted for baseline body mass index because height and weight were measured at baseline, allowing for calculation of body mass index and other variables. Both body weight and WC changes were categorized as change within 5% (stable), decrease by 5% to 10%, decrease by more than 10%, increase by 5% to 10%, and increase by more than 10%.MAIN OUTCOMES AND MEASURES: All-cause, cancer-specific, CVD-specific, and noncancer non-CVD-specific mortality. Mortality events were adjudicated by an expert review panel. Cox proportional hazards regression and competing risk analyses were used to calculate hazard ratios (HRs) and 95% CIs.RESULTS: Among 16 523 participants (mean [SD] age, 75.0 [4.3] years; 9193 women [55.6%]), 1256 deaths were observed over a mean (SD) of 4.4 (1.7) years. Compared with men with stable weight, those with a 5% to 10% weight loss had a 33% higher (HR, 1.33; 95% CI, 1.07-1.66) risk of all-cause mortality, and those with more than a 10% decrease in body weight had a 289% higher (HR, 3.89; 95% CI, 2.93-5.18) risk. Compared with women with stable weight, those with a 5% to 10% weight loss had a 26% higher (HR, 1.26; 95% CI, 1.00-1.60) risk of all-cause mortality, and those with more than a 10% decrease in body weight had a 114% higher (HR, 2.14; 95% CI, 1.58-2.91) risk. Weight loss was associated with a higher cancer-specific mortality (>10% decrease among men: HR, 3.49; 95% CI, 2.26-5.40; 5%-10% decrease among women: HR, 1.44; 95% CI, 1.46-2.04; >10% decrease among women: HR, 2.78; 95% CI, 1.82-4.26), CVD-specific mortality (>10% decrease among men: HR, 3.14; 95% CI, 1.63-6.04; >10% decrease among women: HR, 1.92; 95% CI, 1.05-3.51), and noncancer non-CVD-specific mortality (>10% decrease among men: HR, 4.98; 95% CI, 3.14-7.91). A decrease in WC was also associated with mortality.CONCLUSIONS AND RELEVANCE: This cohort study of healthy older adults suggests that weight loss was associated with an increase in all-cause and cause-specific mortality, including an increased risk of cancer, CVD, and other life-limiting conditions. Physicians should be aware of the significance of weight loss, especially among older men.

AB - IMPORTANCE: The association between weight change and subsequent cause-specific mortality among older adults is not well described. The significance of changes in waist circumference (WC) has also not been compared with weight change for this purpose.OBJECTIVE: To examine the associations of changes in body weight and WC with all-cause and cause-specific mortality.DESIGN, SETTING, AND PARTICIPANTS: This cohort study is a post hoc analysis of data from the Aspirin in Reducing Events in the Elderly (ASPREE) randomized clinical trial, which recruited participants between March 1, 2010, and December 31, 2014. The study included community-based older adults (16 703 Australian participants aged ≥70 years and 2411 US participants aged ≥65 years) without evident cardiovascular disease (CVD), dementia, physical disability, or life-limiting chronic illness. Data analysis was performed from April to September 2022.EXPOSURES: Body weight and WC were measured at baseline and at annual visit 2. Analysis models were adjusted for baseline body mass index because height and weight were measured at baseline, allowing for calculation of body mass index and other variables. Both body weight and WC changes were categorized as change within 5% (stable), decrease by 5% to 10%, decrease by more than 10%, increase by 5% to 10%, and increase by more than 10%.MAIN OUTCOMES AND MEASURES: All-cause, cancer-specific, CVD-specific, and noncancer non-CVD-specific mortality. Mortality events were adjudicated by an expert review panel. Cox proportional hazards regression and competing risk analyses were used to calculate hazard ratios (HRs) and 95% CIs.RESULTS: Among 16 523 participants (mean [SD] age, 75.0 [4.3] years; 9193 women [55.6%]), 1256 deaths were observed over a mean (SD) of 4.4 (1.7) years. Compared with men with stable weight, those with a 5% to 10% weight loss had a 33% higher (HR, 1.33; 95% CI, 1.07-1.66) risk of all-cause mortality, and those with more than a 10% decrease in body weight had a 289% higher (HR, 3.89; 95% CI, 2.93-5.18) risk. Compared with women with stable weight, those with a 5% to 10% weight loss had a 26% higher (HR, 1.26; 95% CI, 1.00-1.60) risk of all-cause mortality, and those with more than a 10% decrease in body weight had a 114% higher (HR, 2.14; 95% CI, 1.58-2.91) risk. Weight loss was associated with a higher cancer-specific mortality (>10% decrease among men: HR, 3.49; 95% CI, 2.26-5.40; 5%-10% decrease among women: HR, 1.44; 95% CI, 1.46-2.04; >10% decrease among women: HR, 2.78; 95% CI, 1.82-4.26), CVD-specific mortality (>10% decrease among men: HR, 3.14; 95% CI, 1.63-6.04; >10% decrease among women: HR, 1.92; 95% CI, 1.05-3.51), and noncancer non-CVD-specific mortality (>10% decrease among men: HR, 4.98; 95% CI, 3.14-7.91). A decrease in WC was also associated with mortality.CONCLUSIONS AND RELEVANCE: This cohort study of healthy older adults suggests that weight loss was associated with an increase in all-cause and cause-specific mortality, including an increased risk of cancer, CVD, and other life-limiting conditions. Physicians should be aware of the significance of weight loss, especially among older men.

KW - Male

KW - Aged

KW - Humans

KW - Female

KW - Cohort Studies

KW - Cause of Death

KW - Risk Factors

KW - Australia/epidemiology

KW - Cardiovascular Diseases

KW - Weight Loss

KW - Neoplasms

KW - Waist Circumference

U2 - 10.1001/jamanetworkopen.2023.7482

DO - 10.1001/jamanetworkopen.2023.7482

M3 - SCORING: Journal article

C2 - 37036703

VL - 6

SP - e237482

JO - JAMA NETW OPEN

JF - JAMA NETW OPEN

SN - 2574-3805

IS - 4

ER -