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Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children

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Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children : the German Multicenter Atopy Study. / Liu, Xin; Beaty, Terri H; Deindl, Philipp; Huang, Shau-Ku; Lau, Susanne; Sommerfeld, Christine; Fallin, M Daniele; Kao, W H Linda; Wahn, Ulrich; Nickel, Renate.

In: J ALLERGY CLIN IMMUN, Vol. 112, No. 2, 01.08.2003, p. 382-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Liu, X, Beaty, TH, Deindl, P, Huang, S-K, Lau, S, Sommerfeld, C, Fallin, MD, Kao, WHL, Wahn, U & Nickel, R 2003, 'Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study', J ALLERGY CLIN IMMUN, vol. 112, no. 2, pp. 382-8.

APA

Liu, X., Beaty, T. H., Deindl, P., Huang, S-K., Lau, S., Sommerfeld, C., Fallin, M. D., Kao, W. H. L., Wahn, U., & Nickel, R. (2003). Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. J ALLERGY CLIN IMMUN, 112(2), 382-8.

Vancouver

Liu X, Beaty TH, Deindl P, Huang S-K, Lau S, Sommerfeld C et al. Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. J ALLERGY CLIN IMMUN. 2003 Aug 1;112(2):382-8.

Bibtex

@article{09c7281a142d45b7bfc4ca24cdd2026d,
title = "Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study",
abstract = "BACKGROUND: Increased total serum IgE levels are a common characteristic of atopic disorders. Six potentially functional variants, including C-590T in the IL4 gene, C-1055T and Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene, have been evaluated for their involvement in the control of total serum IgE levels and related atopic disorders, but the results of these studies have been inconsistent.OBJECTIVE: We examined whether these 6 variants had genotypic effects on total serum IgE levels in 823 unrelated German children from a large infant cohort, the German Multicenter Atopy Study.METHODS: Marginal effect models were used for the analyses of the repeated IgE measurements. Weighted linear regression and family-based tests of association were performed to minimize the possibility of spurious effects caused by selection bias or confounding on the basis of ethnic background.RESULTS: There are significant associations between increased total serum IgE levels and 2 variants in the IL13 gene (P <.005 and.0002 for Arg130Gln and C-1055T, respectively). These genetic effects are unlikely to be due to solely linkage disequilibrium between 2 polymorphisms, population stratification, or nonrepresentative samples. In addition, exposure to maternal smoking appears to modify the above effects on total serum IgE levels. However, no statistical association was observed between this quantitative phenotype and the other 4 variants examined.CONCLUSION: These findings suggest that variants C-1055T and Arg130Gln of the IL13 gene might play an important role on total serum IgE production in this study population.",
keywords = "Alleles, Arginine, Child, Cohort Studies, Cysteine, Female, Gene Frequency, Genetic Variation, Genotype, Germany, Glutamine, Humans, Immunoglobulin E, Interleukin-13, Interleukin-4, Linkage Disequilibrium, Mothers, Phenotype, Pregnancy, Prenatal Exposure Delayed Effects, Receptors, Interleukin-4, Smoking, Threonine",
author = "Xin Liu and Beaty, {Terri H} and Philipp Deindl and Shau-Ku Huang and Susanne Lau and Christine Sommerfeld and Fallin, {M Daniele} and Kao, {W H Linda} and Ulrich Wahn and Renate Nickel",
year = "2003",
month = aug,
day = "1",
language = "English",
volume = "112",
pages = "382--8",
journal = "J ALLERGY CLIN IMMUN",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children

T2 - the German Multicenter Atopy Study

AU - Liu, Xin

AU - Beaty, Terri H

AU - Deindl, Philipp

AU - Huang, Shau-Ku

AU - Lau, Susanne

AU - Sommerfeld, Christine

AU - Fallin, M Daniele

AU - Kao, W H Linda

AU - Wahn, Ulrich

AU - Nickel, Renate

PY - 2003/8/1

Y1 - 2003/8/1

N2 - BACKGROUND: Increased total serum IgE levels are a common characteristic of atopic disorders. Six potentially functional variants, including C-590T in the IL4 gene, C-1055T and Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene, have been evaluated for their involvement in the control of total serum IgE levels and related atopic disorders, but the results of these studies have been inconsistent.OBJECTIVE: We examined whether these 6 variants had genotypic effects on total serum IgE levels in 823 unrelated German children from a large infant cohort, the German Multicenter Atopy Study.METHODS: Marginal effect models were used for the analyses of the repeated IgE measurements. Weighted linear regression and family-based tests of association were performed to minimize the possibility of spurious effects caused by selection bias or confounding on the basis of ethnic background.RESULTS: There are significant associations between increased total serum IgE levels and 2 variants in the IL13 gene (P <.005 and.0002 for Arg130Gln and C-1055T, respectively). These genetic effects are unlikely to be due to solely linkage disequilibrium between 2 polymorphisms, population stratification, or nonrepresentative samples. In addition, exposure to maternal smoking appears to modify the above effects on total serum IgE levels. However, no statistical association was observed between this quantitative phenotype and the other 4 variants examined.CONCLUSION: These findings suggest that variants C-1055T and Arg130Gln of the IL13 gene might play an important role on total serum IgE production in this study population.

AB - BACKGROUND: Increased total serum IgE levels are a common characteristic of atopic disorders. Six potentially functional variants, including C-590T in the IL4 gene, C-1055T and Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene, have been evaluated for their involvement in the control of total serum IgE levels and related atopic disorders, but the results of these studies have been inconsistent.OBJECTIVE: We examined whether these 6 variants had genotypic effects on total serum IgE levels in 823 unrelated German children from a large infant cohort, the German Multicenter Atopy Study.METHODS: Marginal effect models were used for the analyses of the repeated IgE measurements. Weighted linear regression and family-based tests of association were performed to minimize the possibility of spurious effects caused by selection bias or confounding on the basis of ethnic background.RESULTS: There are significant associations between increased total serum IgE levels and 2 variants in the IL13 gene (P <.005 and.0002 for Arg130Gln and C-1055T, respectively). These genetic effects are unlikely to be due to solely linkage disequilibrium between 2 polymorphisms, population stratification, or nonrepresentative samples. In addition, exposure to maternal smoking appears to modify the above effects on total serum IgE levels. However, no statistical association was observed between this quantitative phenotype and the other 4 variants examined.CONCLUSION: These findings suggest that variants C-1055T and Arg130Gln of the IL13 gene might play an important role on total serum IgE production in this study population.

KW - Alleles

KW - Arginine

KW - Child

KW - Cohort Studies

KW - Cysteine

KW - Female

KW - Gene Frequency

KW - Genetic Variation

KW - Genotype

KW - Germany

KW - Glutamine

KW - Humans

KW - Immunoglobulin E

KW - Interleukin-13

KW - Interleukin-4

KW - Linkage Disequilibrium

KW - Mothers

KW - Phenotype

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Receptors, Interleukin-4

KW - Smoking

KW - Threonine

M3 - SCORING: Journal article

C2 - 12897746

VL - 112

SP - 382

EP - 388

JO - J ALLERGY CLIN IMMUN

JF - J ALLERGY CLIN IMMUN

SN - 0091-6749

IS - 2

ER -