Research ExplorerPublicationsAssociations between statin treatment and markers of inflamm...

Associations between statin treatment and markers of inflammation, vasoconstriction, and coagulation in patients with abdominal aortic aneurysm

Standard

Associations between statin treatment and markers of inflammation, vasoconstriction, and coagulation in patients with abdominal aortic aneurysm. / Gottsäter, Anders; Flondell-Site, Despina; Kölbel, Tilo; Lindblad, Bengt.

In: VASC ENDOVASC SURG, Vol. 42, No. 6, 16.07.2008, p. 567-573.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gottsäter, A, Flondell-Site, D, Kölbel, T & Lindblad, B 2008, 'Associations between statin treatment and markers of inflammation, vasoconstriction, and coagulation in patients with abdominal aortic aneurysm', VASC ENDOVASC SURG, vol. 42, no. 6, pp. 567-573. https://doi.org/10.1177/1538574408320027

APA

Gottsäter, A., Flondell-Site, D., Kölbel, T., & Lindblad, B. (2008). Associations between statin treatment and markers of inflammation, vasoconstriction, and coagulation in patients with abdominal aortic aneurysm. VASC ENDOVASC SURG, 42(6), 567-573. https://doi.org/10.1177/1538574408320027

Vancouver

Gottsäter A, Flondell-Site D, Kölbel T, Lindblad B. Associations between statin treatment and markers of inflammation, vasoconstriction, and coagulation in patients with abdominal aortic aneurysm. VASC ENDOVASC SURG. 2008 Jul 16;42(6):567-573. https://doi.org/10.1177/1538574408320027

Bibtex

@article{64c5e43adddb4516be071c834fc87850,
title = "Associations between statin treatment and markers of inflammation, vasoconstriction, and coagulation in patients with abdominal aortic aneurysm",
abstract = "The association of statins with markers of inflammation, vasoconstriction, and coagulation was evaluated in 325 patients with abdominal aortic aneurysm with respect to statin treatment or not. Variables evaluated included routine laboratory markers, lipids, homocysteine, endothelin-1, matrix metalloproteinases (MMP)-2 and -9, and activated protein C-protein C inhibitor (APC-PCI) complex. Statin-treated patients were more often male (85% vs 75%; P = .024) and had ischemic heart disease (57% vs 19%; P < .0001). They showed lower levels of cholesterol (P < .0001), homocysteine (P = .027), MMP-9 (P = .038), and endothelin-1 (P = .005), and higher levels of APC-PCI complex (P = .042). Differences persisted in logistic regression for cholesterol (P < .0001), APC-PCI complex (P = .034), and homocysteine (P = .021). Statin-treated patients with abdominal aortic aneurysm show higher APC-PCI complex and lower homocysteine levels. Whether this translates into lower risk for aneurysm expansion or rupture will be evident from further follow-up.",
keywords = "Aged, Aged, 80 and over, Aortic Aneurysm, Abdominal/blood, Biomarkers/blood, Blood Coagulation, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Inflammation Mediators/blood, Logistic Models, Male, Sex Factors, Treatment Outcome, Vasoconstriction",
author = "Anders Gotts{\"a}ter and Despina Flondell-Site and Tilo K{\"o}lbel and Bengt Lindblad",
year = "2008",
month = jul,
day = "16",
doi = "10.1177/1538574408320027",
language = "English",
volume = "42",
pages = "567--573",
journal = "VASC ENDOVASC SURG",
issn = "1538-5744",
publisher = "SAGE Publications",
number = "6",

}

RIS

TY - JOUR

T1 - Associations between statin treatment and markers of inflammation, vasoconstriction, and coagulation in patients with abdominal aortic aneurysm

AU - Gottsäter, Anders

AU - Flondell-Site, Despina

AU - Kölbel, Tilo

AU - Lindblad, Bengt

PY - 2008/7/16

Y1 - 2008/7/16

N2 - The association of statins with markers of inflammation, vasoconstriction, and coagulation was evaluated in 325 patients with abdominal aortic aneurysm with respect to statin treatment or not. Variables evaluated included routine laboratory markers, lipids, homocysteine, endothelin-1, matrix metalloproteinases (MMP)-2 and -9, and activated protein C-protein C inhibitor (APC-PCI) complex. Statin-treated patients were more often male (85% vs 75%; P = .024) and had ischemic heart disease (57% vs 19%; P < .0001). They showed lower levels of cholesterol (P < .0001), homocysteine (P = .027), MMP-9 (P = .038), and endothelin-1 (P = .005), and higher levels of APC-PCI complex (P = .042). Differences persisted in logistic regression for cholesterol (P < .0001), APC-PCI complex (P = .034), and homocysteine (P = .021). Statin-treated patients with abdominal aortic aneurysm show higher APC-PCI complex and lower homocysteine levels. Whether this translates into lower risk for aneurysm expansion or rupture will be evident from further follow-up.

AB - The association of statins with markers of inflammation, vasoconstriction, and coagulation was evaluated in 325 patients with abdominal aortic aneurysm with respect to statin treatment or not. Variables evaluated included routine laboratory markers, lipids, homocysteine, endothelin-1, matrix metalloproteinases (MMP)-2 and -9, and activated protein C-protein C inhibitor (APC-PCI) complex. Statin-treated patients were more often male (85% vs 75%; P = .024) and had ischemic heart disease (57% vs 19%; P < .0001). They showed lower levels of cholesterol (P < .0001), homocysteine (P = .027), MMP-9 (P = .038), and endothelin-1 (P = .005), and higher levels of APC-PCI complex (P = .042). Differences persisted in logistic regression for cholesterol (P < .0001), APC-PCI complex (P = .034), and homocysteine (P = .021). Statin-treated patients with abdominal aortic aneurysm show higher APC-PCI complex and lower homocysteine levels. Whether this translates into lower risk for aneurysm expansion or rupture will be evident from further follow-up.

KW - Aged

KW - Aged, 80 and over

KW - Aortic Aneurysm, Abdominal/blood

KW - Biomarkers/blood

KW - Blood Coagulation

KW - Female

KW - Humans

KW - Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use

KW - Inflammation Mediators/blood

KW - Logistic Models

KW - Male

KW - Sex Factors

KW - Treatment Outcome

KW - Vasoconstriction

U2 - 10.1177/1538574408320027

DO - 10.1177/1538574408320027

M3 - SCORING: Journal article

C2 - 18621884

VL - 42

SP - 567

EP - 573

JO - VASC ENDOVASC SURG

JF - VASC ENDOVASC SURG

SN - 1538-5744

IS - 6

ER -