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Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children

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Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children : the German Multicenter Atopy Study. / Liu, Xin; Beaty, Terri H; Deindl, Philipp; Huang, Shau-Ku; Lau, Susanne; Sommerfeld, Christine; Fallin, M Daniele; Kao, W H Linda; Wahn, Ulrich; Nickel, Renate.

In: J ALLERGY CLIN IMMUN, Vol. 113, No. 3, 01.03.2004, p. 489-95.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Liu, X, Beaty, TH, Deindl, P, Huang, S-K, Lau, S, Sommerfeld, C, Fallin, MD, Kao, WHL, Wahn, U & Nickel, R 2004, 'Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study', J ALLERGY CLIN IMMUN, vol. 113, no. 3, pp. 489-95. https://doi.org/10.1016/j.jaci.2003.12.037

APA

Liu, X., Beaty, T. H., Deindl, P., Huang, S-K., Lau, S., Sommerfeld, C., Fallin, M. D., Kao, W. H. L., Wahn, U., & Nickel, R. (2004). Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. J ALLERGY CLIN IMMUN, 113(3), 489-95. https://doi.org/10.1016/j.jaci.2003.12.037

Vancouver

Liu X, Beaty TH, Deindl P, Huang S-K, Lau S, Sommerfeld C et al. Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. J ALLERGY CLIN IMMUN. 2004 Mar 1;113(3):489-95. https://doi.org/10.1016/j.jaci.2003.12.037

Bibtex

@article{6dac2ddaaa994cc8b84f83bede012bfc,
title = "Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study",
abstract = "BACKGROUND: Among many published studies of specific IgE response or atopy, only a few showed positive marginal effects for 6 potentially functional single nucleotide polymorphisms (SNPs; C-590T in the IL4 gene, C-1055T and Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene). SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors.OBJECTIVE: We tested the relationship between these 6 SNPs and sensitization to food, mite, cat, and outdoor allergens in unrelated German children drawn from the Multicenter Atopy Study. Gene-gene and gene-environment interactions were also evaluated.METHODS: Multiple logistic regression models were used for the analyses of 4 sensitization outcomes.RESULTS: The variant C-1055T was significantly associated with increased risk of sensitization to food and outdoor allergens, with odds ratios of 3.49 (95% CI, 1.52-8.02) and 2.27 (95% CI, 1.04-4.94), respectively. The effects of the TT genotype on food sensitization appear to depend on variants in the IL4RA gene, in which marginally significant interaction terms were observed. Significant evidence supported an interaction between exposure to maternal smoking and variant Gln551Arg on risk of cat sensitization. In addition, we found that the effect of variant C-590T on sensitization to mite depended on Der p 1 allergen levels in carpet dust samples.CONCLUSIONS: These findings not only suggested that variants in the IL4, IL13, and IL4RA genes play an important role in controlling specific IgE response but also strengthened our understanding of gene-gene and gene-environment interaction on the development of specific sensitization in this study population.",
keywords = "Allergens, Animals, Case-Control Studies, Cats, Child, Child, Preschool, Female, Food Hypersensitivity, Genetic Variation, Germany, Humans, Hypersensitivity, Immediate, Immunoglobulin E, Infant, Interleukin-13, Interleukin-4, Male, Mites, Receptors, Interleukin-4",
author = "Xin Liu and Beaty, {Terri H} and Philipp Deindl and Shau-Ku Huang and Susanne Lau and Christine Sommerfeld and Fallin, {M Daniele} and Kao, {W H Linda} and Ulrich Wahn and Renate Nickel",
year = "2004",
month = mar,
day = "1",
doi = "10.1016/j.jaci.2003.12.037",
language = "English",
volume = "113",
pages = "489--95",
journal = "J ALLERGY CLIN IMMUN",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children

T2 - the German Multicenter Atopy Study

AU - Liu, Xin

AU - Beaty, Terri H

AU - Deindl, Philipp

AU - Huang, Shau-Ku

AU - Lau, Susanne

AU - Sommerfeld, Christine

AU - Fallin, M Daniele

AU - Kao, W H Linda

AU - Wahn, Ulrich

AU - Nickel, Renate

PY - 2004/3/1

Y1 - 2004/3/1

N2 - BACKGROUND: Among many published studies of specific IgE response or atopy, only a few showed positive marginal effects for 6 potentially functional single nucleotide polymorphisms (SNPs; C-590T in the IL4 gene, C-1055T and Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene). SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors.OBJECTIVE: We tested the relationship between these 6 SNPs and sensitization to food, mite, cat, and outdoor allergens in unrelated German children drawn from the Multicenter Atopy Study. Gene-gene and gene-environment interactions were also evaluated.METHODS: Multiple logistic regression models were used for the analyses of 4 sensitization outcomes.RESULTS: The variant C-1055T was significantly associated with increased risk of sensitization to food and outdoor allergens, with odds ratios of 3.49 (95% CI, 1.52-8.02) and 2.27 (95% CI, 1.04-4.94), respectively. The effects of the TT genotype on food sensitization appear to depend on variants in the IL4RA gene, in which marginally significant interaction terms were observed. Significant evidence supported an interaction between exposure to maternal smoking and variant Gln551Arg on risk of cat sensitization. In addition, we found that the effect of variant C-590T on sensitization to mite depended on Der p 1 allergen levels in carpet dust samples.CONCLUSIONS: These findings not only suggested that variants in the IL4, IL13, and IL4RA genes play an important role in controlling specific IgE response but also strengthened our understanding of gene-gene and gene-environment interaction on the development of specific sensitization in this study population.

AB - BACKGROUND: Among many published studies of specific IgE response or atopy, only a few showed positive marginal effects for 6 potentially functional single nucleotide polymorphisms (SNPs; C-590T in the IL4 gene, C-1055T and Arg130Gln in the IL13 gene, and Ile50Val, Ser478Pro, and Gln551Arg in the IL4RA gene). SNPs were commonly considered individually, and therefore the true effect could be masked by other genes or environmental factors.OBJECTIVE: We tested the relationship between these 6 SNPs and sensitization to food, mite, cat, and outdoor allergens in unrelated German children drawn from the Multicenter Atopy Study. Gene-gene and gene-environment interactions were also evaluated.METHODS: Multiple logistic regression models were used for the analyses of 4 sensitization outcomes.RESULTS: The variant C-1055T was significantly associated with increased risk of sensitization to food and outdoor allergens, with odds ratios of 3.49 (95% CI, 1.52-8.02) and 2.27 (95% CI, 1.04-4.94), respectively. The effects of the TT genotype on food sensitization appear to depend on variants in the IL4RA gene, in which marginally significant interaction terms were observed. Significant evidence supported an interaction between exposure to maternal smoking and variant Gln551Arg on risk of cat sensitization. In addition, we found that the effect of variant C-590T on sensitization to mite depended on Der p 1 allergen levels in carpet dust samples.CONCLUSIONS: These findings not only suggested that variants in the IL4, IL13, and IL4RA genes play an important role in controlling specific IgE response but also strengthened our understanding of gene-gene and gene-environment interaction on the development of specific sensitization in this study population.

KW - Allergens

KW - Animals

KW - Case-Control Studies

KW - Cats

KW - Child

KW - Child, Preschool

KW - Female

KW - Food Hypersensitivity

KW - Genetic Variation

KW - Germany

KW - Humans

KW - Hypersensitivity, Immediate

KW - Immunoglobulin E

KW - Infant

KW - Interleukin-13

KW - Interleukin-4

KW - Male

KW - Mites

KW - Receptors, Interleukin-4

U2 - 10.1016/j.jaci.2003.12.037

DO - 10.1016/j.jaci.2003.12.037

M3 - SCORING: Journal article

C2 - 15007352

VL - 113

SP - 489

EP - 495

JO - J ALLERGY CLIN IMMUN

JF - J ALLERGY CLIN IMMUN

SN - 0091-6749

IS - 3

ER -