Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study

Nina Sophia Decker; Theron Johnson; Charlotte Le Cornet; Sabine Behrens; Nadia Obi; Rudolf Kaaks; Jenny Chang-Claude; Renée Turzanski Fortner

doi:10.1038/s41598-024-55316-x

Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study

Standard

Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study. / Decker, Nina Sophia; Johnson, Theron; Le Cornet, Charlotte; Behrens, Sabine; Obi, Nadia; Kaaks, Rudolf; Chang-Claude, Jenny; Fortner, Renée Turzanski.

In: SCI REP-UK, Vol. 14, No. 1, 29.02.2024, p. 4977.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Decker, NS, Johnson, T, Le Cornet, C, Behrens, S, Obi, N, Kaaks, R, Chang-Claude, J & Fortner, RT 2024, 'Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study', SCI REP-UK, vol. 14, no. 1, pp. 4977. https://doi.org/10.1038/s41598-024-55316-x

APA

Decker, N. S., Johnson, T., Le Cornet, C., Behrens, S., Obi, N., Kaaks, R., Chang-Claude, J., & Fortner, R. T. (2024). Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study. SCI REP-UK, 14(1), 4977. https://doi.org/10.1038/s41598-024-55316-x

Vancouver

Decker NS, Johnson T, Le Cornet C, Behrens S, Obi N, Kaaks R et al. Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study. SCI REP-UK. 2024 Feb 29;14(1):4977. https://doi.org/10.1038/s41598-024-55316-x

Bibtex

@article{5fa31153c20b4eddaeb7c338fbab65aa,

title = "Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study",

abstract = "Despite increasing evidence that cholesterol precursors and oxysterols, oxidized cholesterol metabolites, play a role in numerous pathological processes and diseases including breast cancer, little is known about correlates of these sterols in women with breast cancer. In this study, 2282 women with breast cancer and blood draw post diagnosis were included and cross-sectional associations between circulating levels of 15 sterols/oxysterols and (a) lifestyle, anthropometric, reproductive characteristics, (b) comorbidities and medication use, and (c) breast cancer tumor and treatment characteristics were calculated using generalized linear models. Obesity was strongly associated with circulating levels of 7-dehydrocholesterol (DC) (body mass index ≥ 30 vs. 18.5-24.9 kg/m2: 51.7% difference) and 7-ketocholesterol (KC) (40.0% difference). After adjustment for BMI, comorbidities such as cardiovascular disease were associated with higher levels of 7-DC (26.1% difference) and lower levels of desmosterol (- 16.4% difference). Breast cancer tumor characteristics including hormone receptor status, tumor stage, and endocrine therapy were associated with lanosterol, 24-DHLan, 7b-HC, and THC (e.g., THC; tumor stage IIIa vs. I: 36.9% difference). Weaker associations were observed for lifestyle characteristics and for any of the other oxysterols. The findings of this study suggest that cholesterol precursors are strongly associated with metabolic factors, while oxysterols are associated with breast cancer tumor characteristics, warranting further investigation into the role of cholesterol precursors and oxysterols in women with breast cancer and other populations.",

keywords = "Humans, Female, Oxysterols/metabolism, Cross-Sectional Studies, Breast Neoplasms/metabolism, Cholesterol/metabolism, Sterols, Phytosterols, Life Style",

author = "Decker, {Nina Sophia} and Theron Johnson and {Le Cornet}, Charlotte and Sabine Behrens and Nadia Obi and Rudolf Kaaks and Jenny Chang-Claude and Fortner, {Ren{\'e}e Turzanski}",

note = "{\textcopyright} 2024. The Author(s).",

year = "2024",

month = feb,

day = "29",

doi = "10.1038/s41598-024-55316-x",

language = "English",

volume = "14",

pages = "4977",

journal = "SCI REP-UK",

issn = "2045-2322",

publisher = "NATURE PUBLISHING GROUP",

number = "1",

}

RIS

TY - JOUR

T1 - Associations between lifestyle, health, and clinical characteristics and circulating oxysterols and cholesterol precursors in women diagnosed with breast cancer: a cross-sectional study

AU - Decker, Nina Sophia

AU - Johnson, Theron

AU - Le Cornet, Charlotte

AU - Behrens, Sabine

AU - Obi, Nadia

AU - Kaaks, Rudolf

AU - Chang-Claude, Jenny

AU - Fortner, Renée Turzanski

PY - 2024/2/29

Y1 - 2024/2/29

N2 - Despite increasing evidence that cholesterol precursors and oxysterols, oxidized cholesterol metabolites, play a role in numerous pathological processes and diseases including breast cancer, little is known about correlates of these sterols in women with breast cancer. In this study, 2282 women with breast cancer and blood draw post diagnosis were included and cross-sectional associations between circulating levels of 15 sterols/oxysterols and (a) lifestyle, anthropometric, reproductive characteristics, (b) comorbidities and medication use, and (c) breast cancer tumor and treatment characteristics were calculated using generalized linear models. Obesity was strongly associated with circulating levels of 7-dehydrocholesterol (DC) (body mass index ≥ 30 vs. 18.5-24.9 kg/m2: 51.7% difference) and 7-ketocholesterol (KC) (40.0% difference). After adjustment for BMI, comorbidities such as cardiovascular disease were associated with higher levels of 7-DC (26.1% difference) and lower levels of desmosterol (- 16.4% difference). Breast cancer tumor characteristics including hormone receptor status, tumor stage, and endocrine therapy were associated with lanosterol, 24-DHLan, 7b-HC, and THC (e.g., THC; tumor stage IIIa vs. I: 36.9% difference). Weaker associations were observed for lifestyle characteristics and for any of the other oxysterols. The findings of this study suggest that cholesterol precursors are strongly associated with metabolic factors, while oxysterols are associated with breast cancer tumor characteristics, warranting further investigation into the role of cholesterol precursors and oxysterols in women with breast cancer and other populations.

AB - Despite increasing evidence that cholesterol precursors and oxysterols, oxidized cholesterol metabolites, play a role in numerous pathological processes and diseases including breast cancer, little is known about correlates of these sterols in women with breast cancer. In this study, 2282 women with breast cancer and blood draw post diagnosis were included and cross-sectional associations between circulating levels of 15 sterols/oxysterols and (a) lifestyle, anthropometric, reproductive characteristics, (b) comorbidities and medication use, and (c) breast cancer tumor and treatment characteristics were calculated using generalized linear models. Obesity was strongly associated with circulating levels of 7-dehydrocholesterol (DC) (body mass index ≥ 30 vs. 18.5-24.9 kg/m2: 51.7% difference) and 7-ketocholesterol (KC) (40.0% difference). After adjustment for BMI, comorbidities such as cardiovascular disease were associated with higher levels of 7-DC (26.1% difference) and lower levels of desmosterol (- 16.4% difference). Breast cancer tumor characteristics including hormone receptor status, tumor stage, and endocrine therapy were associated with lanosterol, 24-DHLan, 7b-HC, and THC (e.g., THC; tumor stage IIIa vs. I: 36.9% difference). Weaker associations were observed for lifestyle characteristics and for any of the other oxysterols. The findings of this study suggest that cholesterol precursors are strongly associated with metabolic factors, while oxysterols are associated with breast cancer tumor characteristics, warranting further investigation into the role of cholesterol precursors and oxysterols in women with breast cancer and other populations.

KW - Humans

KW - Female

KW - Oxysterols/metabolism

KW - Cross-Sectional Studies

KW - Breast Neoplasms/metabolism

KW - Cholesterol/metabolism

KW - Sterols

KW - Phytosterols

KW - Life Style

U2 - 10.1038/s41598-024-55316-x

DO - 10.1038/s41598-024-55316-x

M3 - SCORING: Journal article

C2 - 38424253

VL - 14

SP - 4977

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -