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Association of subcellular localization of TEAD transcription factors with outcome and progression in pancreatic ductal adenocarcinoma

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Association of subcellular localization of TEAD transcription factors with outcome and progression in pancreatic ductal adenocarcinoma. / Drexler, Richard; Fahy, Rebecca; Küchler, Mirco; Wagner, Kim C.; Reese, Tim; Ehmke, Mareike; Feyerabend, Bernd; Kleine, Moritz; Oldhafer, Karl J.

In: PANCREATOLOGY, Vol. 21, No. 1, 01.2021, p. 170-179.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Drexler, R, Fahy, R, Küchler, M, Wagner, KC, Reese, T, Ehmke, M, Feyerabend, B, Kleine, M & Oldhafer, KJ 2021, 'Association of subcellular localization of TEAD transcription factors with outcome and progression in pancreatic ductal adenocarcinoma', PANCREATOLOGY, vol. 21, no. 1, pp. 170-179. https://doi.org/10.1016/j.pan.2020.12.003

APA

Drexler, R., Fahy, R., Küchler, M., Wagner, K. C., Reese, T., Ehmke, M., Feyerabend, B., Kleine, M., & Oldhafer, K. J. (2021). Association of subcellular localization of TEAD transcription factors with outcome and progression in pancreatic ductal adenocarcinoma. PANCREATOLOGY, 21(1), 170-179. https://doi.org/10.1016/j.pan.2020.12.003

Vancouver

Drexler R, Fahy R, Küchler M, Wagner KC, Reese T, Ehmke M et al. Association of subcellular localization of TEAD transcription factors with outcome and progression in pancreatic ductal adenocarcinoma. PANCREATOLOGY. 2021 Jan;21(1):170-179. https://doi.org/10.1016/j.pan.2020.12.003

Bibtex

@article{797b3e10ae174d62a2832e1bf5f386db,
title = "Association of subcellular localization of TEAD transcription factors with outcome and progression in pancreatic ductal adenocarcinoma",
abstract = "BackgroundTranscriptional enhanced associated domain (TEAD) transcription factors are nuclear effectors of several oncogenic signalling pathways including Hippo, WNT, TGF-{\ss} and EGFR pathways that interact with various cancer genes. The subcellular localization of TEAD regulates the functional output of these pathways affecting tumour progression and patient outcome. However, the impact of the TEAD family on pancreatic ductal adenocarcinoma (PDAC) and its clinical progression remain elusive.MethodsA cohort of 81 PDAC patients who had undergone surgery was established. Cytoplasmic and nuclear localization of TEAD1, TEAD2, TEAD3 and TEAD4 was evaluated with the immunoreactive score (IRS) by immunohistochemistry (IHC) using paraffin-embedded tissue. Results were correlated with clinicopathological data, disease-free and overall survival.ResultsNuclear staining of all four TEADs was increased in pancreatic cancer tissue. Patients suffering from metastatic disease at time of surgery showed a strong nuclear staining of TEAD2 and TEAD3 (p < 0.05). Furthermore, a nuclear > cytoplasmic ratio of TEAD2 and TEAD3 was associated with a shorter overall survival and TEAD2 emerged as an independent prognostic factor for disease-free survival.ConclusionOur study underlines the importance of TEAD transcription factors in PDAC as a nuclear localization was found to be associated with metastatic disease and an unfavourable prognosis after surgical resection.",
author = "Richard Drexler and Rebecca Fahy and Mirco K{\"u}chler and Wagner, {Kim C.} and Tim Reese and Mareike Ehmke and Bernd Feyerabend and Moritz Kleine and Oldhafer, {Karl J.}",
year = "2021",
month = jan,
doi = "10.1016/j.pan.2020.12.003",
language = "English",
volume = "21",
pages = "170--179",
journal = "PANCREATOLOGY",
issn = "1424-3903",
publisher = "S. Karger AG",
number = "1",

}

RIS

TY - JOUR

T1 - Association of subcellular localization of TEAD transcription factors with outcome and progression in pancreatic ductal adenocarcinoma

AU - Drexler, Richard

AU - Fahy, Rebecca

AU - Küchler, Mirco

AU - Wagner, Kim C.

AU - Reese, Tim

AU - Ehmke, Mareike

AU - Feyerabend, Bernd

AU - Kleine, Moritz

AU - Oldhafer, Karl J.

PY - 2021/1

Y1 - 2021/1

N2 - BackgroundTranscriptional enhanced associated domain (TEAD) transcription factors are nuclear effectors of several oncogenic signalling pathways including Hippo, WNT, TGF-ß and EGFR pathways that interact with various cancer genes. The subcellular localization of TEAD regulates the functional output of these pathways affecting tumour progression and patient outcome. However, the impact of the TEAD family on pancreatic ductal adenocarcinoma (PDAC) and its clinical progression remain elusive.MethodsA cohort of 81 PDAC patients who had undergone surgery was established. Cytoplasmic and nuclear localization of TEAD1, TEAD2, TEAD3 and TEAD4 was evaluated with the immunoreactive score (IRS) by immunohistochemistry (IHC) using paraffin-embedded tissue. Results were correlated with clinicopathological data, disease-free and overall survival.ResultsNuclear staining of all four TEADs was increased in pancreatic cancer tissue. Patients suffering from metastatic disease at time of surgery showed a strong nuclear staining of TEAD2 and TEAD3 (p < 0.05). Furthermore, a nuclear > cytoplasmic ratio of TEAD2 and TEAD3 was associated with a shorter overall survival and TEAD2 emerged as an independent prognostic factor for disease-free survival.ConclusionOur study underlines the importance of TEAD transcription factors in PDAC as a nuclear localization was found to be associated with metastatic disease and an unfavourable prognosis after surgical resection.

AB - BackgroundTranscriptional enhanced associated domain (TEAD) transcription factors are nuclear effectors of several oncogenic signalling pathways including Hippo, WNT, TGF-ß and EGFR pathways that interact with various cancer genes. The subcellular localization of TEAD regulates the functional output of these pathways affecting tumour progression and patient outcome. However, the impact of the TEAD family on pancreatic ductal adenocarcinoma (PDAC) and its clinical progression remain elusive.MethodsA cohort of 81 PDAC patients who had undergone surgery was established. Cytoplasmic and nuclear localization of TEAD1, TEAD2, TEAD3 and TEAD4 was evaluated with the immunoreactive score (IRS) by immunohistochemistry (IHC) using paraffin-embedded tissue. Results were correlated with clinicopathological data, disease-free and overall survival.ResultsNuclear staining of all four TEADs was increased in pancreatic cancer tissue. Patients suffering from metastatic disease at time of surgery showed a strong nuclear staining of TEAD2 and TEAD3 (p < 0.05). Furthermore, a nuclear > cytoplasmic ratio of TEAD2 and TEAD3 was associated with a shorter overall survival and TEAD2 emerged as an independent prognostic factor for disease-free survival.ConclusionOur study underlines the importance of TEAD transcription factors in PDAC as a nuclear localization was found to be associated with metastatic disease and an unfavourable prognosis after surgical resection.

UR - https://doi.org/10.1016/j.pan.2020.12.003

U2 - 10.1016/j.pan.2020.12.003

DO - 10.1016/j.pan.2020.12.003

M3 - SCORING: Journal article

VL - 21

SP - 170

EP - 179

JO - PANCREATOLOGY

JF - PANCREATOLOGY

SN - 1424-3903

IS - 1

ER -