Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery

Athanasios Chalkias; Nikolaos Papagiannakis; Bernd Saugel; Moritz Flick; Konstantina Kolonia; Zacharoula Angelopoulou; Dimitrios Ragias; Dimitra Papaspyrou; Aikaterini Bouzia; Nicoletta Ntalarizou; Konstantinos Stamoulis; Aikaterini Kyriakaki; Jesper Eugen-Olsen; Eleni Laou; Eleni Arnaoutoglou

doi:10.3390/jcm11123326

Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery

Standard

Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery. / Chalkias, Athanasios; Papagiannakis, Nikolaos; Saugel, Bernd ; Flick, Moritz; Kolonia, Konstantina; Angelopoulou, Zacharoula; Ragias, Dimitrios; Papaspyrou, Dimitra; Bouzia, Aikaterini; Ntalarizou, Nicoletta; Stamoulis, Konstantinos; Kyriakaki, Aikaterini; Eugen-Olsen, Jesper; Laou, Eleni; Arnaoutoglou, Eleni.

In: J CLIN MED, Vol. 11, No. 12, 3326, 10.06.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Chalkias, A, Papagiannakis, N, Saugel, B , Flick, M, Kolonia, K, Angelopoulou, Z, Ragias, D, Papaspyrou, D, Bouzia, A, Ntalarizou, N, Stamoulis, K, Kyriakaki, A, Eugen-Olsen, J, Laou, E & Arnaoutoglou, E 2022, 'Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery', J CLIN MED, vol. 11, no. 12, 3326. https://doi.org/10.3390/jcm11123326

APA

Chalkias, A., Papagiannakis, N., Saugel, B., Flick, M., Kolonia, K., Angelopoulou, Z., Ragias, D., Papaspyrou, D., Bouzia, A., Ntalarizou, N., Stamoulis, K., Kyriakaki, A., Eugen-Olsen, J., Laou, E., & Arnaoutoglou, E. (2022). Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery. J CLIN MED, 11(12), [3326]. https://doi.org/10.3390/jcm11123326

Vancouver

Chalkias A, Papagiannakis N, Saugel B , Flick M, Kolonia K, Angelopoulou Z et al. Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery. J CLIN MED. 2022 Jun 10;11(12). 3326. https://doi.org/10.3390/jcm11123326

Bibtex

@article{76e494bd57014da6a69903300a020fba,

title = "Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery",

abstract = "It remains unknown whether chronic systemic inflammation is associated with impaired microvascular perfusion during surgery. We evaluated the association between the preoperative basal inflammatory state, measured by plasma soluble urokinase-type plasminogen activator receptor (suPAR) levels, and intraoperative sublingual microcirculatory variables in patients undergoing major non-cardiac surgery. Plasma suPAR levels were determined in 100 non-cardiac surgery patients using the suPARnostic{\textregistered} quick triage lateral flow assay. We assessed sublingual microcirculation before surgical incision and every 30 min during surgery using Sidestream Darkfield (SDF+) imaging and determined the De Backer score, the Consensus Proportion of Perfused Vessels (Consensus PPV), and the Consensus PPV (small). Elevated suPAR levels were associated with lower intraoperative De Backer score, Consensus PPV, and Consensus PPV (small). For each ng mL−1 increase in suPAR, De Backer score, Consensus PPV, and Consensus PPV (small) decreased by 0.7 mm−1, 2.5%, and 2.8%, respectively, compared to baseline. In contrast, CRP was not significantly correlated with De Backer score (r = −0.034, p = 0.36), Consensus PPV (r = −0.014, p = 0.72) or Consensus PPV Small (r = −0.037, p = 0.32). Postoperative De Backer score did not change significantly from baseline (5.95 ± 3.21 vs. 5.89 ± 3.36, p = 0.404), while postoperative Consensus PPV (83.49 ± 11.5 vs. 81.15 ± 11.8, p < 0.001) and Consensus PPV (small) (80.87 ± 13.4 vs. 78.72 ± 13, p < 0.001) decreased significantly from baseline. In conclusion, elevated preoperative suPAR levels were associated with intraoperative impairment of sublingual microvascular perfusion in patients undergoing elective major non-cardiac surgery.",

author = "Athanasios Chalkias and Nikolaos Papagiannakis and Bernd Saugel and Moritz Flick and Konstantina Kolonia and Zacharoula Angelopoulou and Dimitrios Ragias and Dimitra Papaspyrou and Aikaterini Bouzia and Nicoletta Ntalarizou and Konstantinos Stamoulis and Aikaterini Kyriakaki and Jesper Eugen-Olsen and Eleni Laou and Eleni Arnaoutoglou",

year = "2022",

month = jun,

day = "10",

doi = "10.3390/jcm11123326",

language = "English",

volume = "11",

journal = "J CLIN MED",

issn = "2077-0383",

publisher = "MDPI AG",

number = "12",

}

RIS

TY - JOUR

T1 - Association of Preoperative Basal Inflammatory State, Measured by Plasma suPAR Levels, with Intraoperative Sublingual Microvascular Perfusion in Patients Undergoing Major Non-Cardiac Surgery

AU - Chalkias, Athanasios

AU - Papagiannakis, Nikolaos

AU - Saugel, Bernd

AU - Flick, Moritz

AU - Kolonia, Konstantina

AU - Angelopoulou, Zacharoula

AU - Ragias, Dimitrios

AU - Papaspyrou, Dimitra

AU - Bouzia, Aikaterini

AU - Ntalarizou, Nicoletta

AU - Stamoulis, Konstantinos

AU - Kyriakaki, Aikaterini

AU - Eugen-Olsen, Jesper

AU - Laou, Eleni

AU - Arnaoutoglou, Eleni

PY - 2022/6/10

Y1 - 2022/6/10

N2 - It remains unknown whether chronic systemic inflammation is associated with impaired microvascular perfusion during surgery. We evaluated the association between the preoperative basal inflammatory state, measured by plasma soluble urokinase-type plasminogen activator receptor (suPAR) levels, and intraoperative sublingual microcirculatory variables in patients undergoing major non-cardiac surgery. Plasma suPAR levels were determined in 100 non-cardiac surgery patients using the suPARnostic® quick triage lateral flow assay. We assessed sublingual microcirculation before surgical incision and every 30 min during surgery using Sidestream Darkfield (SDF+) imaging and determined the De Backer score, the Consensus Proportion of Perfused Vessels (Consensus PPV), and the Consensus PPV (small). Elevated suPAR levels were associated with lower intraoperative De Backer score, Consensus PPV, and Consensus PPV (small). For each ng mL−1 increase in suPAR, De Backer score, Consensus PPV, and Consensus PPV (small) decreased by 0.7 mm−1, 2.5%, and 2.8%, respectively, compared to baseline. In contrast, CRP was not significantly correlated with De Backer score (r = −0.034, p = 0.36), Consensus PPV (r = −0.014, p = 0.72) or Consensus PPV Small (r = −0.037, p = 0.32). Postoperative De Backer score did not change significantly from baseline (5.95 ± 3.21 vs. 5.89 ± 3.36, p = 0.404), while postoperative Consensus PPV (83.49 ± 11.5 vs. 81.15 ± 11.8, p < 0.001) and Consensus PPV (small) (80.87 ± 13.4 vs. 78.72 ± 13, p < 0.001) decreased significantly from baseline. In conclusion, elevated preoperative suPAR levels were associated with intraoperative impairment of sublingual microvascular perfusion in patients undergoing elective major non-cardiac surgery.

AB - It remains unknown whether chronic systemic inflammation is associated with impaired microvascular perfusion during surgery. We evaluated the association between the preoperative basal inflammatory state, measured by plasma soluble urokinase-type plasminogen activator receptor (suPAR) levels, and intraoperative sublingual microcirculatory variables in patients undergoing major non-cardiac surgery. Plasma suPAR levels were determined in 100 non-cardiac surgery patients using the suPARnostic® quick triage lateral flow assay. We assessed sublingual microcirculation before surgical incision and every 30 min during surgery using Sidestream Darkfield (SDF+) imaging and determined the De Backer score, the Consensus Proportion of Perfused Vessels (Consensus PPV), and the Consensus PPV (small). Elevated suPAR levels were associated with lower intraoperative De Backer score, Consensus PPV, and Consensus PPV (small). For each ng mL−1 increase in suPAR, De Backer score, Consensus PPV, and Consensus PPV (small) decreased by 0.7 mm−1, 2.5%, and 2.8%, respectively, compared to baseline. In contrast, CRP was not significantly correlated with De Backer score (r = −0.034, p = 0.36), Consensus PPV (r = −0.014, p = 0.72) or Consensus PPV Small (r = −0.037, p = 0.32). Postoperative De Backer score did not change significantly from baseline (5.95 ± 3.21 vs. 5.89 ± 3.36, p = 0.404), while postoperative Consensus PPV (83.49 ± 11.5 vs. 81.15 ± 11.8, p < 0.001) and Consensus PPV (small) (80.87 ± 13.4 vs. 78.72 ± 13, p < 0.001) decreased significantly from baseline. In conclusion, elevated preoperative suPAR levels were associated with intraoperative impairment of sublingual microvascular perfusion in patients undergoing elective major non-cardiac surgery.

U2 - 10.3390/jcm11123326

DO - 10.3390/jcm11123326

M3 - SCORING: Journal article

C2 - 35743397

VL - 11

JO - J CLIN MED

JF - J CLIN MED

SN - 2077-0383

IS - 12

M1 - 3326

ER -