Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study.
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Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study. / Pikula, Aleksandra; Böger, Rainer; Beiser, Alexa S; Maas, Renke; DeCarli, Charles; Schwedhelm, Edzard; Himali, Jayandra J; Schulze, Friedrich; Au, Rhoda; Kelly-Hayes, Margaret; Kase, Carlos S; Vasan, Ramachandran S; Wolf, Philip A; Seshadri, Sudha.
In: STROKE, Vol. 40, No. 9, 9, 2009, p. 2959-2964.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study.
AU - Pikula, Aleksandra
AU - Böger, Rainer
AU - Beiser, Alexa S
AU - Maas, Renke
AU - DeCarli, Charles
AU - Schwedhelm, Edzard
AU - Himali, Jayandra J
AU - Schulze, Friedrich
AU - Au, Rhoda
AU - Kelly-Hayes, Margaret
AU - Kase, Carlos S
AU - Vasan, Ramachandran S
AU - Wolf, Philip A
AU - Seshadri, Sudha
PY - 2009
Y1 - 2009
N2 - BACKGROUND AND PURPOSE: Asymmetrical dimethylarginine (ADMA), an inhibitor of endothelial nitric oxide synthase, is a marker of endothelial dysfunction. Elevated circulating ADMA concentrations have been associated with systemic and carotid atherosclerosis, an elevated risk of developing stroke, and magnetic resonance imaging white-matter hyperintensities (WMHs). The relation of plasma ADMA to subclinical vascular brain injury has not been previously studied in a middle-aged, community-based sample. METHODS: In 2013 stroke-free Framingham offspring (mean+/-SD age, 58+/-9.5 years; 53% women), we related baseline plasma ADMA levels (1995-1998) to subsequent brain magnetic resonance imaging measures (1999-2004) of subclinical vascular injury: presence of silent brain infarcts (SBIs) and large white-matter hyperintensity volumes (LWMHs; defined as >1 SD above the age-specific mean). RESULTS: Prevalences of SBIs and LWMHs were 10.7% and 12.6%, respectively. In multivariable analyses adjusting for age, sex and traditional stroke risk factors, higher ADMA levels were associated with an increased risk of prevalent SBIs (odds ratio [OR] per 1-SD increase in ADMA=1.16; 95% CI, 1.01 to 1.33; P=0.04). We observed that participants in the upper 3 age-specific quartiles (Qs) of plasma ADMA values had an increased prevalence of SBIs (OR for Q2-Q4 vs Q1=1.43; 95% CI, 1.00 to 2.04; P
AB - BACKGROUND AND PURPOSE: Asymmetrical dimethylarginine (ADMA), an inhibitor of endothelial nitric oxide synthase, is a marker of endothelial dysfunction. Elevated circulating ADMA concentrations have been associated with systemic and carotid atherosclerosis, an elevated risk of developing stroke, and magnetic resonance imaging white-matter hyperintensities (WMHs). The relation of plasma ADMA to subclinical vascular brain injury has not been previously studied in a middle-aged, community-based sample. METHODS: In 2013 stroke-free Framingham offspring (mean+/-SD age, 58+/-9.5 years; 53% women), we related baseline plasma ADMA levels (1995-1998) to subsequent brain magnetic resonance imaging measures (1999-2004) of subclinical vascular injury: presence of silent brain infarcts (SBIs) and large white-matter hyperintensity volumes (LWMHs; defined as >1 SD above the age-specific mean). RESULTS: Prevalences of SBIs and LWMHs were 10.7% and 12.6%, respectively. In multivariable analyses adjusting for age, sex and traditional stroke risk factors, higher ADMA levels were associated with an increased risk of prevalent SBIs (odds ratio [OR] per 1-SD increase in ADMA=1.16; 95% CI, 1.01 to 1.33; P=0.04). We observed that participants in the upper 3 age-specific quartiles (Qs) of plasma ADMA values had an increased prevalence of SBIs (OR for Q2-Q4 vs Q1=1.43; 95% CI, 1.00 to 2.04; P
M3 - SCORING: Zeitschriftenaufsatz
VL - 40
SP - 2959
EP - 2964
JO - STROKE
JF - STROKE
SN - 0039-2499
IS - 9
M1 - 9
ER -
