Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V.
Standard
Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V. / Aberle, Jens; Hopfer, I; Beil, F U; Seedorf, U.
In: INT J OBESITY, Vol. 30, No. 12, 12, 2006, p. 1709-1713.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Association of peroxisome proliferator-activated receptor delta +294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V.
AU - Aberle, Jens
AU - Hopfer, I
AU - Beil, F U
AU - Seedorf, U
PY - 2006
Y1 - 2006
N2 - OBJECTIVE: To investigate the association of a polymorphism at position 294 (+294T/C) in the Peroxisome Proliferator-activated Receptor delta (PPARdelta) with body mass index (BMI) and the additional role of a gene-to-gene interaction between PPARdelta, PPARalpha and PPARgamma. DESIGN: An association between genetic variations in PPARdelta, PPARalpha and PPARgamma and indices of obesity and metabolism. SUBJECTS: A group of 462 moderately obese (mean BMI 28.9+/-7.7) and dyslipidemic, middle-aged (mean age 43.9+/-13.7), Caucasion men and women.Measurements:The three most frequent single-nucleotide-polymorphisms (snp) in PPARdelta (+294T/C), PPARalpha (L162V) and PPARgamma (P12A) were genotyped and associated with clinical parameters.Results:The C allele in PPARdelta was significantly associated with a lower body mass index. Moreover an interaction between the polymorphisms in PPARalpha and PPARdelta on body weight could be demonstrated. CONCLUSION: Our data provide further evidence for an involvement of PPARdelta in the regulation of BMI.
AB - OBJECTIVE: To investigate the association of a polymorphism at position 294 (+294T/C) in the Peroxisome Proliferator-activated Receptor delta (PPARdelta) with body mass index (BMI) and the additional role of a gene-to-gene interaction between PPARdelta, PPARalpha and PPARgamma. DESIGN: An association between genetic variations in PPARdelta, PPARalpha and PPARgamma and indices of obesity and metabolism. SUBJECTS: A group of 462 moderately obese (mean BMI 28.9+/-7.7) and dyslipidemic, middle-aged (mean age 43.9+/-13.7), Caucasion men and women.Measurements:The three most frequent single-nucleotide-polymorphisms (snp) in PPARdelta (+294T/C), PPARalpha (L162V) and PPARgamma (P12A) were genotyped and associated with clinical parameters.Results:The C allele in PPARdelta was significantly associated with a lower body mass index. Moreover an interaction between the polymorphisms in PPARalpha and PPARdelta on body weight could be demonstrated. CONCLUSION: Our data provide further evidence for an involvement of PPARdelta in the regulation of BMI.
M3 - SCORING: Zeitschriftenaufsatz
VL - 30
SP - 1709
EP - 1713
JO - INT J OBESITY
JF - INT J OBESITY
SN - 0307-0565
IS - 12
M1 - 12
ER -