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Association of multiple biomarkers and classical risk factors with early carotid atherosclerosis: results from the Gutenberg Health Study

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Association of multiple biomarkers and classical risk factors with early carotid atherosclerosis: results from the Gutenberg Health Study. / Sinning, Christoph; Kieback, Arne; Wild, Philipp S; Schnabel, Renate B; Ojeda Echevarria, Francisco Miguel; Appelbaum, Sebastian; Zeller, Tanja; Lubos, Edith; Schwedhelm, Edzard; Lackner, Karl J; Debus, Eike S; Munzel, Thomas; Blankenberg, Stefan; Espinola-Klein, Christine.

In: CLIN RES CARDIOL, Vol. 103, No. 6, 01.06.2014, p. 477-85.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sinning, C, Kieback, A, Wild, PS, Schnabel, RB, Ojeda Echevarria, FM, Appelbaum, S, Zeller, T, Lubos, E, Schwedhelm, E, Lackner, KJ, Debus, ES, Munzel, T, Blankenberg, S & Espinola-Klein, C 2014, 'Association of multiple biomarkers and classical risk factors with early carotid atherosclerosis: results from the Gutenberg Health Study', CLIN RES CARDIOL, vol. 103, no. 6, pp. 477-85. https://doi.org/10.1007/s00392-014-0674-6

APA

Sinning, C., Kieback, A., Wild, P. S., Schnabel, R. B., Ojeda Echevarria, F. M., Appelbaum, S., Zeller, T., Lubos, E., Schwedhelm, E., Lackner, K. J., Debus, E. S., Munzel, T., Blankenberg, S., & Espinola-Klein, C. (2014). Association of multiple biomarkers and classical risk factors with early carotid atherosclerosis: results from the Gutenberg Health Study. CLIN RES CARDIOL, 103(6), 477-85. https://doi.org/10.1007/s00392-014-0674-6

Vancouver

Sinning C, Kieback A, Wild PS, Schnabel RB, Ojeda Echevarria FM, Appelbaum S et al. Association of multiple biomarkers and classical risk factors with early carotid atherosclerosis: results from the Gutenberg Health Study. CLIN RES CARDIOL. 2014 Jun 1;103(6):477-85. https://doi.org/10.1007/s00392-014-0674-6

Bibtex

@article{17d8bf960c594812a59feef79b955365,
title = "Association of multiple biomarkers and classical risk factors with early carotid atherosclerosis: results from the Gutenberg Health Study",
abstract = "BACKGROUND: In the Gutenberg Health Study, a random sample of the population was scanned with vascular ultrasound for early atherosclerosis. A continuous classical risk marker model (waist circumference, HbA1c, LDL/HDL ratio, pack years and pulse pressure) was compared to a model of modern biomarkers (C-reactive protein, troponin I, N-terminal pro B-type natriuretic peptide, copeptin, mid-regional pro-adrenomedullin, and asymmetric dimethylarginine) with regard to the ability of ruling out abnormal intima-media thickness (IMT), respectively, carotid plaques.METHODS: Data of the first consecutive 5,000 participants (aged 35-74 years; 2,540 men, 2,460 women) were analyzed. IMT was measured at both common carotid arteries using an edge detection system. Plaques were defined as protrusion of ≥1.5 mm in common, internal and external carotid artery.RESULTS: For classical risk factors, in comparison to a model of six modern biomarkers, regarding the variable (a) IMT>0.85 mm negative and positive predictive value (NPV and PPV) were 0.98 and 0.16 for both the classical risk factor model and the biomarker model. The second variable (b) presence of plaque could be ruled out with an NPV of 0.84 and identified with a PPV of 0.61 for classical risk factors, and 0.84 and 0.58 for biomarkers, respectively. Values were calculated using logistic regression analysis.CONCLUSION: Classical risk factors allow ruling out pathologic IMT and presence of carotid plaques in a population of primary prevention in a reliable way. Modern biomarkers performed almost equally well but did not provide further information.",
author = "Christoph Sinning and Arne Kieback and Wild, {Philipp S} and Schnabel, {Renate B} and {Ojeda Echevarria}, {Francisco Miguel} and Sebastian Appelbaum and Tanja Zeller and Edith Lubos and Edzard Schwedhelm and Lackner, {Karl J} and Debus, {Eike S} and Thomas Munzel and Stefan Blankenberg and Christine Espinola-Klein",
year = "2014",
month = jun,
day = "1",
doi = "10.1007/s00392-014-0674-6",
language = "English",
volume = "103",
pages = "477--85",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "6",

}

RIS

TY - JOUR

T1 - Association of multiple biomarkers and classical risk factors with early carotid atherosclerosis: results from the Gutenberg Health Study

AU - Sinning, Christoph

AU - Kieback, Arne

AU - Wild, Philipp S

AU - Schnabel, Renate B

AU - Ojeda Echevarria, Francisco Miguel

AU - Appelbaum, Sebastian

AU - Zeller, Tanja

AU - Lubos, Edith

AU - Schwedhelm, Edzard

AU - Lackner, Karl J

AU - Debus, Eike S

AU - Munzel, Thomas

AU - Blankenberg, Stefan

AU - Espinola-Klein, Christine

PY - 2014/6/1

Y1 - 2014/6/1

N2 - BACKGROUND: In the Gutenberg Health Study, a random sample of the population was scanned with vascular ultrasound for early atherosclerosis. A continuous classical risk marker model (waist circumference, HbA1c, LDL/HDL ratio, pack years and pulse pressure) was compared to a model of modern biomarkers (C-reactive protein, troponin I, N-terminal pro B-type natriuretic peptide, copeptin, mid-regional pro-adrenomedullin, and asymmetric dimethylarginine) with regard to the ability of ruling out abnormal intima-media thickness (IMT), respectively, carotid plaques.METHODS: Data of the first consecutive 5,000 participants (aged 35-74 years; 2,540 men, 2,460 women) were analyzed. IMT was measured at both common carotid arteries using an edge detection system. Plaques were defined as protrusion of ≥1.5 mm in common, internal and external carotid artery.RESULTS: For classical risk factors, in comparison to a model of six modern biomarkers, regarding the variable (a) IMT>0.85 mm negative and positive predictive value (NPV and PPV) were 0.98 and 0.16 for both the classical risk factor model and the biomarker model. The second variable (b) presence of plaque could be ruled out with an NPV of 0.84 and identified with a PPV of 0.61 for classical risk factors, and 0.84 and 0.58 for biomarkers, respectively. Values were calculated using logistic regression analysis.CONCLUSION: Classical risk factors allow ruling out pathologic IMT and presence of carotid plaques in a population of primary prevention in a reliable way. Modern biomarkers performed almost equally well but did not provide further information.

AB - BACKGROUND: In the Gutenberg Health Study, a random sample of the population was scanned with vascular ultrasound for early atherosclerosis. A continuous classical risk marker model (waist circumference, HbA1c, LDL/HDL ratio, pack years and pulse pressure) was compared to a model of modern biomarkers (C-reactive protein, troponin I, N-terminal pro B-type natriuretic peptide, copeptin, mid-regional pro-adrenomedullin, and asymmetric dimethylarginine) with regard to the ability of ruling out abnormal intima-media thickness (IMT), respectively, carotid plaques.METHODS: Data of the first consecutive 5,000 participants (aged 35-74 years; 2,540 men, 2,460 women) were analyzed. IMT was measured at both common carotid arteries using an edge detection system. Plaques were defined as protrusion of ≥1.5 mm in common, internal and external carotid artery.RESULTS: For classical risk factors, in comparison to a model of six modern biomarkers, regarding the variable (a) IMT>0.85 mm negative and positive predictive value (NPV and PPV) were 0.98 and 0.16 for both the classical risk factor model and the biomarker model. The second variable (b) presence of plaque could be ruled out with an NPV of 0.84 and identified with a PPV of 0.61 for classical risk factors, and 0.84 and 0.58 for biomarkers, respectively. Values were calculated using logistic regression analysis.CONCLUSION: Classical risk factors allow ruling out pathologic IMT and presence of carotid plaques in a population of primary prevention in a reliable way. Modern biomarkers performed almost equally well but did not provide further information.

U2 - 10.1007/s00392-014-0674-6

DO - 10.1007/s00392-014-0674-6

M3 - SCORING: Journal article

C2 - 24488175

VL - 103

SP - 477

EP - 485

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 6

ER -