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Association of lipid levels with motor and cognitive function and decline in advanced Parkinson's disease in the Mark-PD study

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Association of lipid levels with motor and cognitive function and decline in advanced Parkinson's disease in the Mark-PD study. / Choe, Chi-Un; Petersen, Elina; Lezius, Susanne; Cheng, Bastian; Schulz, Robert; Buhmann, Carsten; Pötter-Nerger, Monika; Daum, Günter; Blankenberg, Stefan; Gerloff, Christian; Schwedhelm, Edzard; Zeller, Tanja.

In: PARKINSONISM RELAT D, Vol. 85, 04.2021, p. 5-10.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Choe, C-U, Petersen, E, Lezius, S, Cheng, B, Schulz, R, Buhmann, C, Pötter-Nerger, M, Daum, G, Blankenberg, S, Gerloff, C, Schwedhelm, E & Zeller, T 2021, 'Association of lipid levels with motor and cognitive function and decline in advanced Parkinson's disease in the Mark-PD study', PARKINSONISM RELAT D, vol. 85, pp. 5-10. https://doi.org/10.1016/j.parkreldis.2021.02.007

APA

Choe, C-U., Petersen, E., Lezius, S., Cheng, B., Schulz, R., Buhmann, C., Pötter-Nerger, M., Daum, G., Blankenberg, S., Gerloff, C., Schwedhelm, E., & Zeller, T. (2021). Association of lipid levels with motor and cognitive function and decline in advanced Parkinson's disease in the Mark-PD study. PARKINSONISM RELAT D, 85, 5-10. https://doi.org/10.1016/j.parkreldis.2021.02.007

Vancouver

Choe C-U, Petersen E, Lezius S, Cheng B, Schulz R, Buhmann C et al. Association of lipid levels with motor and cognitive function and decline in advanced Parkinson's disease in the Mark-PD study. PARKINSONISM RELAT D. 2021 Apr;85:5-10. https://doi.org/10.1016/j.parkreldis.2021.02.007

Bibtex

@article{c076739af9a049f8b47fb4eccc8adc6f,
title = "Association of lipid levels with motor and cognitive function and decline in advanced Parkinson's disease in the Mark-PD study",
abstract = "OBJECTIVES: In prospective cohort studies different blood lipid fractions have been identified as risk factors of Parkinson's disease (PD). However, data relating lipoproteins to disease phenotypes and progression in advanced PD patients are sparse. Therefore, we assessed the most common lipoproteins in a case-control design and evaluated their associations with motor and cognitive function and decline in PD patients.METHODS: Triglycerides, LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and lipoprotein a (Lp(a)) were analyzed in 294 PD patients of the MARK-PD study cohort and 588 controls matched for age, sex and cardiovascular risk factors. In PD patients, motor (MDS-UPDRS III, Hoehn-Yahr stage) and cognitive function (MoCA) were examined. In a sub-cohort (n = 98 patients), baseline lipid levels were correlated with motor and cognitive disease progression during a follow-up period of 523 ± 199 days.RESULTS: At baseline, HDL-C levels were lower in PD patients compared to matched controls after adjustment. We observed a very weak association of Lp(a) levels with UDPRS III scores. In cross-sectional analyses, no other lipid fraction revealed a significant and consistent association with motor or cognitive function. During follow-up, no lipid fraction level was associated with motor or cognitive progression.CONCLUSION: In advanced PD, there is no strong and consistent association of lipid levels with motor or cognitive function and decline.",
author = "Chi-Un Choe and Elina Petersen and Susanne Lezius and Bastian Cheng and Robert Schulz and Carsten Buhmann and Monika P{\"o}tter-Nerger and G{\"u}nter Daum and Stefan Blankenberg and Christian Gerloff and Edzard Schwedhelm and Tanja Zeller",
note = "Copyright {\textcopyright} 2021 Elsevier Ltd. All rights reserved.",
year = "2021",
month = apr,
doi = "10.1016/j.parkreldis.2021.02.007",
language = "English",
volume = "85",
pages = "5--10",
journal = "PARKINSONISM RELAT D",
issn = "1353-8020",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Association of lipid levels with motor and cognitive function and decline in advanced Parkinson's disease in the Mark-PD study

AU - Choe, Chi-Un

AU - Petersen, Elina

AU - Lezius, Susanne

AU - Cheng, Bastian

AU - Schulz, Robert

AU - Buhmann, Carsten

AU - Pötter-Nerger, Monika

AU - Daum, Günter

AU - Blankenberg, Stefan

AU - Gerloff, Christian

AU - Schwedhelm, Edzard

AU - Zeller, Tanja

N1 - Copyright © 2021 Elsevier Ltd. All rights reserved.

PY - 2021/4

Y1 - 2021/4

N2 - OBJECTIVES: In prospective cohort studies different blood lipid fractions have been identified as risk factors of Parkinson's disease (PD). However, data relating lipoproteins to disease phenotypes and progression in advanced PD patients are sparse. Therefore, we assessed the most common lipoproteins in a case-control design and evaluated their associations with motor and cognitive function and decline in PD patients.METHODS: Triglycerides, LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and lipoprotein a (Lp(a)) were analyzed in 294 PD patients of the MARK-PD study cohort and 588 controls matched for age, sex and cardiovascular risk factors. In PD patients, motor (MDS-UPDRS III, Hoehn-Yahr stage) and cognitive function (MoCA) were examined. In a sub-cohort (n = 98 patients), baseline lipid levels were correlated with motor and cognitive disease progression during a follow-up period of 523 ± 199 days.RESULTS: At baseline, HDL-C levels were lower in PD patients compared to matched controls after adjustment. We observed a very weak association of Lp(a) levels with UDPRS III scores. In cross-sectional analyses, no other lipid fraction revealed a significant and consistent association with motor or cognitive function. During follow-up, no lipid fraction level was associated with motor or cognitive progression.CONCLUSION: In advanced PD, there is no strong and consistent association of lipid levels with motor or cognitive function and decline.

AB - OBJECTIVES: In prospective cohort studies different blood lipid fractions have been identified as risk factors of Parkinson's disease (PD). However, data relating lipoproteins to disease phenotypes and progression in advanced PD patients are sparse. Therefore, we assessed the most common lipoproteins in a case-control design and evaluated their associations with motor and cognitive function and decline in PD patients.METHODS: Triglycerides, LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and lipoprotein a (Lp(a)) were analyzed in 294 PD patients of the MARK-PD study cohort and 588 controls matched for age, sex and cardiovascular risk factors. In PD patients, motor (MDS-UPDRS III, Hoehn-Yahr stage) and cognitive function (MoCA) were examined. In a sub-cohort (n = 98 patients), baseline lipid levels were correlated with motor and cognitive disease progression during a follow-up period of 523 ± 199 days.RESULTS: At baseline, HDL-C levels were lower in PD patients compared to matched controls after adjustment. We observed a very weak association of Lp(a) levels with UDPRS III scores. In cross-sectional analyses, no other lipid fraction revealed a significant and consistent association with motor or cognitive function. During follow-up, no lipid fraction level was associated with motor or cognitive progression.CONCLUSION: In advanced PD, there is no strong and consistent association of lipid levels with motor or cognitive function and decline.

U2 - 10.1016/j.parkreldis.2021.02.007

DO - 10.1016/j.parkreldis.2021.02.007

M3 - SCORING: Journal article

C2 - 33636481

VL - 85

SP - 5

EP - 10

JO - PARKINSONISM RELAT D

JF - PARKINSONISM RELAT D

SN - 1353-8020

ER -